scholarly journals Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients With Chronic Obstructive Pulmonary Disease

CHEST Journal ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. A380 ◽  
Author(s):  
Ying Tang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Nk Cells ◽  
Pulmonary Disease ◽  
Peripheral Blood ◽  
Chronic Obstructive ◽  
Inhibitory Receptors ◽  
Obstructive Pulmonary Disease

OR.37. Th17 Response Polarization in Peripheral Blood and Bronchoalveolar Fluid of Patients with Chronic Obstructive Pulmonary Disease

2009 ◽  
Vol 131 ◽  
pp. S17
Author(s):  
María Inés Vargas-Rojas ◽  
Raul Sansores ◽  
Alejandra Ramirez ◽  
Luis Jiménez ◽  
Diana Torres García ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Peripheral Blood ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Th17 Response ◽  
Bronchoalveolar Fluid

A role for NGF and its receptors TrKA and p75NTR in the progression of COPD

2016 ◽  
Vol 397 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Anna Stabile ◽  
Alessandra Pistilli ◽  
Lucia Crispoltoni ◽  
Claudia Montagnoli ◽  
Roberto Tiribuzi ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pulmonary Disease ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Chronic Obstructive ◽  
Peripheral Blood Mononuclear ◽  
Obstructive Pulmonary Disease ◽  
Nerve Growth

Abstract Nerve growth factor and its receptors, TrkA and p75NTR, are involved in inflammation and airways diseases, but their role in chronic obstructive pulmonary disease is still unclear and not well investigated. our data indicate the stage dependent variation of nerve growth factor and its receptors in chronic obstructive pulmonary disease progression. In fact, for the first time, this study evaluates the presence of nerve growth factor and its receptors in serum and in peripheral blood mononuclear cells of patients with different stages of chronic obstructive pulmonary disease compared to healthy subjects, non-smoker and current smoker. Serum monocyte chemoattractant protein-1, tumor necrosis factor-α, interleukin-10 and forced expiratory volume in 1 s were also analyzed. Compared to healthy subjects, chronic obstructive pulmonary disease patients presented a staging-dependent increase in serum nerve growth factor, negatively correlated to forced expiratory volume in 1 s and positively to monocyte chemoattractant Protein-1. The percentage of p75NTR+ peripheral blood mononuclear cells increased in early stages of chronic obstructive pulmonary disease (I–II), while TrKA+ peripheral blood mononuclear cells increased in late stages (III–IV). Our data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging.

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