Targeted DNA Methylation Analysis Explores Association of Adenocarcinoma and Neuroendocrine Epitypes With Lung Cancer

CHEST Journal ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. A320
Author(s):  
Jing Liu
Keyword(s):  
Lung Cancer ◽  
Dna Methylation ◽  
Methylation Analysis ◽  
Dna Methylation Analysis

scholarly journals Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Julia Krushkal ◽  
Thomas Silvers ◽  
William C. Reinhold ◽  
Dmitriy Sonkin ◽  
Suleyman Vural ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Methylation ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Methylation Analysis ◽  
Dna Methylation Analysis

scholarly journals RETRACTED ARTICLE: Targeted DNA methylation analysis explores association of adenocarcinoma and neuroendocrine epitypes with lung cancer

Tumor Biology ◽  
2015 ◽  
Vol 37 (2) ◽  
pp. 2537-2537
Author(s):  
Qing-Sheng Zhao ◽  
Ling-Ling Hu ◽  
Peng Tian ◽  
Zhi-Dong Wang ◽  
Zhao-Pei Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Methylation ◽  
Methylation Analysis ◽  
Retracted Article ◽  
Dna Methylation Analysis

scholarly journals DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Torsten Goldmann ◽  
Bernhard Schmitt ◽  
Julia Müller ◽  
Maren Kröger ◽  
Swetlana Scheufele ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Methylation ◽  
Histopathological Analysis ◽  
Definite Diagnosis ◽  
Methylation Analysis ◽  
Cell Content ◽  
Therapy Regimen ◽  
Bronchoscopic Biopsy ◽  
Diagnosis Of Lung Cancer ◽  
Dna Methylation Analysis

Abstract Background Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20–25% of all cancer deaths. For choosing the most appropriate therapy regimen a definite diagnosis is a prerequisite. However, histological characterization of bronchoscopic biopsies particularly with low tumor cell content is often challenging. Therefore, this study aims at (a) determining the value of DNA methylation analysis applied to specimens obtained by bronchoscopic biopsy for the diagnosis of lung cancer and (b) at comparing aberrantly CpG loci identified in bronchoscopic biopsy with those identified by analyzing surgical specimens. Results We report the HumanMethylation450-based DNA methylation analysis of paired samples of bronchoscopic biopsy specimens either from the tumor side or from the contralateral tumor-free bronchus in 37 patients with definite lung cancer diagnosis and 18 patients with suspicious diagnosis. A differential DNA methylation analysis between both biopsy sites of patients with definite diagnosis identified 1303 loci. Even those samples were separated by the set of 1303 loci in which histopathological analysis could not unambiguously define the dignity. Further differential DNA methylation analyses distinguished between SCLC and NSCLC. We validated our results in an independent cohort of 40 primary lung cancers obtained by open surgical resection and their corresponding controls from the same patient as well as in publically available DNA methylation data from a TCGA cohort which could also be classified with high accuracy. Conclusions Considering that the prognosis correlates with tumor stage at time of diagnosis, early detection of lung cancer is vital and DNA methylation analysis might add valuable information to reliably characterize lung cancer even in histologically ambiguous sample material.

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