Developmental toxicity of 3,4-dichloroaniline on rare minnow (Gobiocypris rarus) embryos and larvae

Chemosphere ◽  
2013 ◽  
Vol 90 (3) ◽  
pp. 1132-1139 ◽  
Author(s):  
Bin Zhu ◽  
Tianqiang Liu ◽  
Xuegang Hu ◽  
Gaoxue Wang
2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yuan-Yuan Xiao ◽  
Li Liu ◽  
Yao Chen ◽  
Yu-Lian Zeng ◽  
Ming-Zhi Liu ◽  
...  

The toxic effects of CDs on rare minnow (Gobiocypris rarus) embryos at different developmental stages were investigated. The results showed that rare minnow embryos had decreased spontaneous movements, body length, increased heart rate, pericardial edema, yolk sac edema, tail/spinal curvature, various morphological malformations, and decreased hatching rate. Biochemical analysis showed the CDs exposure significantly inhibited the activity of Na+/K+-ATPase and Ca2+-ATPase and increased the MDA contents and the activity of SOD, CAT, and GPX. Further examination suggested that the CDs exposure induced serious embryonic cellular DNA damage. Moreover, the CDs exposure induced upregulation of development related genes (Wnt8aandMstn) along with the downregulation ofVezf1. Overall, the present study revealed that the CDs exposure has significant development toxicity on rare minnow embryos/larvae. Mechanistically, this toxicity might result from the pressure of induced oxidative stress coordinate with the dysregulated development related gene expression mediated by the CDs exposure.


2014 ◽  
Vol 104 ◽  
pp. 269-277 ◽  
Author(s):  
Bin Zhu ◽  
Lei Liu ◽  
Dong-Liang Li ◽  
Fei Ling ◽  
Gao-Xue Wang

2018 ◽  
Vol 60 ◽  
pp. 28-36 ◽  
Author(s):  
Yao Chen ◽  
Yang Yang ◽  
Fang Ou ◽  
Li Liu ◽  
Xiao-hong Liu ◽  
...  

2010 ◽  
Vol 36 (4) ◽  
pp. 837-842 ◽  
Author(s):  
Sha LIAO ◽  
Yun CHEN ◽  
Fu-Kuan DU ◽  
Ya-Ping WANG ◽  
Lan-Jie LIAO ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document