scholarly journals Upright Integrated Relaxation Pressure Facilitates Characterization of Esophagogastric Junction Outflow Obstruction

2019 ◽  
Vol 17 (11) ◽  
pp. 2218-2226.e2 ◽  
Author(s):  
Joseph R. Triggs ◽  
Dustin A. Carlson ◽  
Claire Beveridge ◽  
Anand Jain ◽  
Michael Y. Tye ◽  
...  
Keyword(s):  
Esophagogastric Junction ◽  
Outflow Obstruction ◽  
Integrated Relaxation Pressure

Mo1506 - Upright Integrated Relaxation Pressure Facilitates Characterization of Esophagogastric Junction Outlet Obstruction

2018 ◽  
Vol 154 (6) ◽  
pp. S-733 ◽  
Author(s):  
Joseph Triggs ◽  
Dustin Carlson ◽  
Claire Beveridge ◽  
Anand Jain ◽  
Michael Y. Tye ◽  
...  
Keyword(s):  
Esophagogastric Junction ◽  
Outlet Obstruction ◽  
Integrated Relaxation Pressure

scholarly journals Upright Integrated Relaxation Pressure Predicts Symptom Outcome for Esophagogastric Junction Outflow Obstruction

2021 ◽  
Vol 27 (3) ◽  
pp. 363-369
Author(s):  
Songfeng Chen ◽  
Mengya Liang ◽  
Niandi Tan ◽  
Mengyu Zhang ◽  
Yuqing Lin ◽  
...  
Keyword(s):  
Esophagogastric Junction ◽  
Outflow Obstruction ◽  
Symptom Outcome ◽  
Integrated Relaxation Pressure

Esophagogastric junction outflow obstruction: Characterization of a new entity? Clinical, manometric, and neuroimmunological description

2020 ◽  
Vol 32 (8) ◽  
Author(s):  
Janette Furuzawa‐Carballeda ◽  
Enrique Coss‐Adame ◽  
Fernanda Romero‐Hernández ◽  
Joaquín Zúñiga ◽  
Norma Uribe‐Uribe ◽  
...  
Keyword(s):  
Esophagogastric Junction ◽  
Outflow Obstruction

Mo1528 - Esophagogastric Junction Outflow Obstruction Clinical and Immunological Characterization of a New Entity

2018 ◽  
Vol 154 (6) ◽  
pp. S-742
Author(s):  
Fernanda Romero-Hernández ◽  
Janette Furuzawa-Carballeda ◽  
Enrique Coss-Adame ◽  
Miguel A. Valdovinos ◽  
Angélica Rodríguez-Garcés ◽  
...  
Keyword(s):  
Esophagogastric Junction ◽  
Outflow Obstruction ◽  
Immunological Characterization

Characterization of idiopathic esophagogastric junction outflow obstruction

2015 ◽  
Vol 27 (9) ◽  
pp. 1310-1316 ◽  
Author(s):  
F. B. van Hoeij ◽  
A. J. P. M. Smout ◽  
A. J. Bredenoord
Keyword(s):  
Esophagogastric Junction ◽  
Outflow Obstruction

Tu1152 Characterization of Primary Esophagogastric Junction Outflow Obstruction

2015 ◽  
Vol 148 (4) ◽  
pp. S-804-S-805
Author(s):  
Froukje B. van Hoeij ◽  
André Smout ◽  
Albert J. Bredenoord
Keyword(s):  
Esophagogastric Junction ◽  
Outflow Obstruction

scholarly journals Response to multiple rapid swallows shows impaired inhibitory pathways in distal esophageal spasm patients with and without concomitant esophagogastric junction outflow obstruction

2020 ◽  
Vol 33 (10) ◽  
Author(s):  
Patricia V Hernandez ◽  
Luis R Valdovinos ◽  
Jennifer L Horsley-Silva ◽  
Miguel A Valdovinos ◽  
Michael D Crowell ◽  
...  
Keyword(s):  
Esophagogastric Junction ◽  
Botulinum Toxin Injection ◽  
Pneumatic Dilation ◽  
Outflow Obstruction ◽  
Esophageal Body ◽  
Esophageal Spasm ◽  
Inhibitory Pathways ◽  
Healthy Control ◽  
Endoscopic Myotomy ◽  
Integrated Relaxation Pressure

Summary Distal esophageal spasm (DES) is a motility disorder characterized by premature contraction of the esophageal body during single swallows. It is thought to be due to impairment of esophageal inhibitory pathways, but studies to support this are limited. The normal response to multiple rapid swallows (MRS) is deglutitive inhibition of the esophageal body during the MRS sequence. Our aim was to compare the response to MRS in DES patients and healthy control subjects. Response to MRS during HRM was evaluated in 19 DES patients (8 with and 11 without concomitant esophagogastric junction outflow obstruction [EGJOO]) and 24 asymptomatic healthy controls. Patients with prior gastroesophageal surgery, peroral endoscopic myotomy, pneumatic dilation, esophageal botulinum toxin injection within 6 months of HRM, opioid medication use, and esophageal stricture were excluded. Response to MRS was evaluated for complete versus impaired inhibition (esophageal body contractility with distal contractile integral [DCI] > 100 mmHg-sec-cm during MRS), presence of post-MRS contraction augmentation (DCI post MRS greater than single swallow mean DCI), and integrated relaxation pressure (IRP). Impaired deglutitive inhibition during MRS was significantly more frequent in DES compared to controls (89% vs. 0%, P < 0.001), and frequency was similar for DES with versus without concomitant EGJOO (100% vs. 82%, P = 0.48). The proportion of subjects with augmentation post MRS was similar for both groups (37% vs. 38%, P = 1.00), but mean DCI post MRS was higher in DES than controls (3360.0 vs. 1238.9, P = 0.009). IRP was lower during MRS compared to single swallows in all patients, and IRP during MRS was normal in 5 of 8 patients with DES and EGJOO. Our study suggests that impaired deglutitive inhibition during MRS is present in the majority of patients with DES regardless of whether they have concomitant EGJOO, and future studies should explore the usefulness of incorporating response to MRS in the diagnosis of DES.

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