Cancer Risks For Mismatch Repair Gene Mutation Carriers: A Population-Based Early Onset Case-Family Study

2006 ◽  
Vol 4 (4) ◽  
pp. 489-498 ◽  
Author(s):  
M JENKINS ◽  
L BAGLIETTO ◽  
J DOWTY ◽  
C VANVLIET ◽  
L SMITH ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Gene Mutation ◽  
Early Onset ◽  
Family Study ◽  
Population Based ◽  
Mismatch Repair Gene ◽  
Cancer Risks ◽  
Repair Gene ◽  
Mutation Carriers ◽  
Early Onset Case

scholarly journals Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry

2012 ◽  
Vol 11 (3) ◽  
pp. 441-447 ◽  
Author(s):  
Mala Pande ◽  
Chongjuan Wei ◽  
Jinyun Chen ◽  
Christopher I. Amos ◽  
Patrick M. Lynch ◽  
...  
Keyword(s):  
Lynch Syndrome ◽  
Mismatch Repair ◽  
Gene Mutation ◽  
Dna Mismatch Repair ◽  
Mismatch Repair Gene ◽  
Repair Gene ◽  
Dna Mismatch ◽  
Mutation Carriers ◽  
Dna Mismatch Repair Gene

scholarly journals Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers

2016 ◽  
Vol 26 (3) ◽  
pp. 366-375 ◽  
Author(s):  
S. Ghazaleh Dashti ◽  
Daniel D. Buchanan ◽  
Harindra Jayasekara ◽  
Driss Ait Ouakrim ◽  
Mark Clendenning ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Alcohol Consumption ◽  
Mismatch Repair ◽  
Gene Mutation ◽  
Mismatch Repair Gene ◽  
Repair Gene ◽  
Mutation Carriers

Identification of germline mismatch repair gene mutation carriers among paitents with multiple Hnpcc-related tumors

2003 ◽  
Vol 124 (4) ◽  
pp. A550
Author(s):  
Jan H. Kleibeuker ◽  
Maran J.W. Berends ◽  
Harry Hollema ◽  
Robert H. Sijmons ◽  
Elisabeth G.E. De Vries ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Gene Mutation ◽  
Mismatch Repair Gene ◽  
Repair Gene ◽  
Mutation Carriers

scholarly journals Risk of Metachronous Colon Cancer Following Surgery for Rectal Cancer in Mismatch Repair Gene Mutation Carriers

2013 ◽  
Vol 20 (6) ◽  
pp. 1829-1836 ◽  
Author(s):  
Aung Ko Win ◽  
Susan Parry ◽  
Bryan Parry ◽  
Matthew F. Kalady ◽  
Finlay A. Macrae ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Colon Cancer ◽  
Mismatch Repair ◽  
Gene Mutation ◽  
Mismatch Repair Gene ◽  
Repair Gene ◽  
Mutation Carriers

scholarly journals Colorectal and Other Cancer Risks for Carriers and Noncarriers From Families With a DNA Mismatch Repair Gene Mutation: A Prospective Cohort Study

2012 ◽  
Vol 30 (9) ◽  
pp. 958-964 ◽  
Author(s):  
Aung Ko Win ◽  
Joanne P. Young ◽  
Noralane M. Lindor ◽  
Katherine M. Tucker ◽  
Dennis J. Ahnen ◽  
...  
Keyword(s):  
General Population ◽  
Mismatch Repair ◽  
Gene Mutation ◽  
Urinary Bladder Cancer ◽  
Female Breast Cancer ◽  
Mismatch Repair Gene ◽  
Cancer Risks ◽  
Repair Gene ◽  
Increased Risk ◽  
Risk Of Cancer

Purpose To determine whether cancer risks for carriers and noncarriers from families with a mismatch repair (MMR) gene mutation are increased above the risks of the general population. Patients and Methods We prospectively followed a cohort of 446 unaffected carriers of an MMR gene mutation (MLH1, n = 161; MSH2, n = 222; MSH6, n = 47; and PMS2, n = 16) and 1,029 their unaffected relatives who did not carry a mutation every 5 years at recruitment centers of the Colon Cancer Family Registry. For comparison of cancer risk with the general population, we estimated country-, age-, and sex-specific standardized incidence ratios (SIRs) of cancer for carriers and noncarriers. Results Over a median follow-up of 5 years, mutation carriers had an increased risk of colorectal cancer (CRC; SIR, 20.48; 95% CI, 11.71 to 33.27; P < .001), endometrial cancer (SIR, 30.62; 95% CI, 11.24 to 66.64; P < .001), ovarian cancer (SIR, 18.81; 95% CI, 3.88 to 54.95; P < .001), renal cancer (SIR, 11.22; 95% CI, 2.31 to 32.79; P < .001), pancreatic cancer (SIR, 10.68; 95% CI, 2.68 to 47.70; P = .001), gastric cancer (SIR, 9.78; 95% CI, 1.18 to 35.30; P = .009), urinary bladder cancer (SIR, 9.51; 95% CI, 1.15 to 34.37; P = .009), and female breast cancer (SIR, 3.95; 95% CI, 1.59 to 8.13; P = .001). We found no evidence of their noncarrier relatives having an increased risk of any cancer, including CRC (SIR, 1.02; 95% CI, 0.33 to 2.39; P = .97). Conclusion We confirmed that carriers of an MMR gene mutation were at increased risk of a wide variety of cancers, including some cancers not previously recognized as being a result of MMR mutations, and found no evidence of an increased risk of cancer for their noncarrier relatives.

Sign in / Sign up

Export Citation Format

Share Document