scholarly journals Challenges and opportunities in synthetic biology for chemical engineers

2013 ◽  
Vol 103 ◽  
pp. 115-119 ◽  
Author(s):  
Yunzi Luo ◽  
Jung-Kul Lee ◽  
Huimin Zhao
Keyword(s):  
Synthetic Biology ◽  
Challenges And Opportunities

scholarly journals The first 10 years of the international coordination network for standards in systems and synthetic biology (COMBINE)

2020 ◽  
Vol 17 (2-3) ◽  
Author(s):  
Dagmar Waltemath ◽  
Martin Golebiewski ◽  
Michael L Blinov ◽  
Padraig Gleeson ◽  
Henning Hermjakob ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Data Model ◽  
Computational Models ◽  
Life Sciences ◽  
The Past ◽  
Challenges And Opportunities ◽  
Stakeholder Workshop ◽  
Software Engineers ◽  
Future Work ◽  
Modeling In Biology

AbstractThis paper presents a report on outcomes of the 10th Computational Modeling in Biology Network (COMBINE) meeting that was held in Heidelberg, Germany, in July of 2019. The annual event brings together researchers, biocurators and software engineers to present recent results and discuss future work in the area of standards for systems and synthetic biology. The COMBINE initiative coordinates the development of various community standards and formats for computational models in the life sciences. Over the past 10 years, COMBINE has brought together standard communities that have further developed and harmonized their standards for better interoperability of models and data. COMBINE 2019 was co-located with a stakeholder workshop of the European EU-STANDS4PM initiative that aims at harmonized data and model standardization for in silico models in the field of personalized medicine, as well as with the FAIRDOM PALs meeting to discuss findable, accessible, interoperable and reusable (FAIR) data sharing. This report briefly describes the work discussed in invited and contributed talks as well as during breakout sessions. It also highlights recent advancements in data, model, and annotation standardization efforts. Finally, this report concludes with some challenges and opportunities that this community will face during the next 10 years.

scholarly journals Societal impact of synthetic biology: responsible research and innovation (RRI)

2016 ◽  
Vol 60 (4) ◽  
pp. 371-379 ◽  
Author(s):  
Daniel Gregorowius ◽  
Anna Deplazes-Zemp
Keyword(s):  
Synthetic Biology ◽  
Technology Assessment ◽  
Ethical Issues ◽  
Responsible Research And Innovation ◽  
Societal Impact ◽  
Biotechnological Applications ◽  
Research And Innovation ◽  
Challenges And Opportunities ◽  
Living Organisms ◽  
Responsible Research

Synthetic biology is an emerging field at the interface between biology and engineering, which has generated many expectations for beneficial biomedical and biotechnological applications. At the same time, however, it has also raised concerns about risks or the aim of producing new forms of living organisms. Researchers from different disciplines as well as policymakers and the general public have expressed the need for a form of technology assessment that not only deals with technical aspects, but also includes societal and ethical issues. A recent and very influential model of technology assessment that tries to implement these aims is known as RRI (Responsible Research and Innovation). In this paper, we introduce this model and its historical precursor strategies. Based on the societal and ethical issues which are presented in the current literature, we discuss challenges and opportunities of applying the RRI model for the assessment of synthetic biology.

scholarly journals Eukaryotic systems broaden the scope of synthetic biology

2009 ◽  
Vol 187 (5) ◽  
pp. 589-596 ◽  
Author(s):  
Karmella A. Haynes ◽  
Pamela A. Silver
Keyword(s):  
Synthetic Biology ◽  
Nucleic Acids ◽  
Cell Biology ◽  
Cell Behavior ◽  
Cellular Functions ◽  
Complex Cells ◽  
Cellular Processes ◽  
Challenges And Opportunities ◽  
Foundational Work ◽  
Biology Research

Synthetic biology aims to engineer novel cellular functions by assembling well-characterized molecular parts (i.e., nucleic acids and proteins) into biological “devices” that exhibit predictable behavior. Recently, efforts in eukaryotic synthetic biology have sprung from foundational work in bacteria. Designing synthetic circuits to operate reliably in the context of differentiating and morphologically complex cells presents unique challenges and opportunities for progress in the field. This review surveys recent advances in eukaryotic synthetic biology and describes how synthetic systems can be linked to natural cellular processes in order to manipulate cell behavior and to foster new discoveries in cell biology research.

scholarly journals Synthetic biology as it relates to CAM photosynthesis: challenges and opportunities

2014 ◽  
Vol 65 (13) ◽  
pp. 3381-3393 ◽  
Author(s):  
Henrique C. DePaoli ◽  
Anne M. Borland ◽  
Gerald A. Tuskan ◽  
John C. Cushman ◽  
Xiaohan Yang
Keyword(s):  
Synthetic Biology ◽  
Challenges And Opportunities ◽  
Cam Photosynthesis

scholarly journals Co-culture systems and technologies: taking synthetic biology to the next level

2014 ◽  
Vol 11 (96) ◽  
pp. 20140065 ◽  
Author(s):  
Lisa Goers ◽  
Paul Freemont ◽  
Karen M. Polizzi
Keyword(s):  
Synthetic Biology ◽  
Careful Consideration ◽  
Cell Populations ◽  
Culture Techniques ◽  
Culture Systems ◽  
Challenges And Opportunities ◽  
Foundational Research ◽  
Set Up ◽  
Extracellular Environment ◽  
Proof Of Principle

Co-culture techniques find myriad applications in biology for studying natural or synthetic interactions between cell populations. Such techniques are of great importance in synthetic biology, as multi-species cell consortia and other natural or synthetic ecology systems are widely seen to hold enormous potential for foundational research as well as novel industrial, medical and environmental applications with many proof-of-principle studies in recent years. What is needed for co-cultures to fulfil their potential? Cell–cell interactions in co-cultures are strongly influenced by the extracellular environment, which is determined by the experimental set-up, which therefore needs to be given careful consideration. An overview of existing experimental and theoretical co-culture set-ups in synthetic biology and adjacent fields is given here, and challenges and opportunities involved in such experiments are discussed. Greater focus on foundational technology developments for co-cultures is needed for many synthetic biology systems to realize their potential in both applications and answering biological questions.

scholarly journals Synthetic biology of cyanobacteria: unique challenges and opportunities

2013 ◽  
Vol 4 ◽  
Author(s):  
Bertram M. Berla ◽  
Rajib Saha ◽  
Cheryl M. Immethun ◽  
Costas D. Maranas ◽  
Tae Seok Moon ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Challenges And Opportunities
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