Design of stationary phase properties for optimal performance of reactive simulated-moving-bed chromatography

2004 ◽  
Vol 59 (22-23) ◽  
pp. 4951-4956 ◽  
Author(s):  
Guido Ströhlein ◽  
Florian Lode ◽  
Marco Mazzotti ◽  
Massimo Morbidelli
Keyword(s):  
Stationary Phase ◽  
Optimal Performance ◽  
Simulated Moving Bed ◽  
Moving Bed ◽  
Simulated Moving Bed Chromatography ◽  
Phase Properties

Digitized Simulation of the Moving Bed

2020 ◽  
Vol 987 ◽  
pp. 157-161
Author(s):  
Chao Fan Xie ◽  
Rey Chue Huang ◽  
Lin Xu ◽  
Fu Quan Zhang ◽  
Lu Xiong Xu
Keyword(s):  
Stationary Phase ◽  
Chromatographic Separation ◽  
Manufacturing Process ◽  
Theoretical Basis ◽  
Mobile Phase ◽  
Separation Process ◽  
Simulated Moving Bed ◽  
Moving Bed ◽  
Simulated Moving Bed Chromatography ◽  
Chemical Products

Chromatographic separation is an indispensable and important technology in the manufacturing process of chemical products and biomedicine. It uses the distribution differences of a compound in the stationary phase and mobile phase to achieve the separation of the mixture. It is of great value to study the separation process of substances by simulated moving bed chromatography. By digitally simulating the process of moving bed, we can observe the influence of parameter changes on substance analysis by chromatography, and then find out the law of substance separation, which can provide theoretical basis for scientific research of biopharmaceuticals.

Simulated moving bed chromatography under linear conditions

1997 ◽  
Vol 45 (1) ◽  
pp. 109-115 ◽  
Author(s):  
G. Zhong ◽  
T. Yun ◽  
S. Khattabi ◽  
G. Guiochon
Keyword(s):  
Simulated Moving Bed ◽  
Moving Bed ◽  
Simulated Moving Bed Chromatography

scholarly journals The Application of Simulated Moving-Bed Chromatography for the Separation of Ginsenosides in Sanchi Ginseng and American Ginseng

2020 ◽  
Vol 15 (10) ◽  
pp. 1934578X2096467
Author(s):  
Tai Thi Ngoc Dong ◽  
Chih-Hsiung Lin ◽  
Ming-Tsai Liang
Keyword(s):  
Crude Extract ◽  
Large Scale ◽  
Aqueous Ethanol ◽  
American Ginseng ◽  
Simulated Moving Bed ◽  
Moving Bed ◽  
Pharmaceutical Ingredients ◽  
Antisolvent Precipitation ◽  
Simulated Moving Bed Chromatography ◽  
Significant Difference

In this study, the separation of ginsenosides from the crude extract of Sanchi ginseng and American ginseng, obtained by aqueous ethanol extraction, was conducted in a simulated moving bed (SMB) with cleaning in place (CIP) design. Concentrated products with 86.2%, w/w, and 91.5%, w/w, of ginsenosides were obtained by the utilization of CIP-SMB for Sanchi and American ginseng, respectively. This study reveals that CIP-SMB could enrich ginsenosides by removing the retained impurities, which were initially extracted by aqueous ethanol and not removed by either the antisolvent precipitation for Sanchi ginseng or the ethyl acetate extraction for American ginseng. Although the ginsenosides in both ginsengs are similar, the difficulty in applying chromatography to the crude extract differs. A natural crude extract normally contains compounds with significant difference in retention. A traditional SMB with 4 sections will be, consequently, unable to continuously separate the natural products. This study develops methods for pretreating the crude extract and demonstrates the feasibility of continuously separating ginsenosides by using SMB. SMB is an effective technology for large-scale chromatography and can generally resolve solvent and energy consumption problems. This is expected to promote the industrial use of SMB for the production of concentrated ginsenosides as active pharmaceutical ingredients.

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