Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

Shasha Liu; Yuan Liao; Biao Chen; Yuhai Chen; Ziding Yu; Haitao Wei; Lianfeng Zhang; Shile Huang; Paul B. Rothman; George Fu Gao; Ji-Long Chen

doi:10.1016/j.celrep.2020.108627

Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

Cell Reports ◽

10.1016/j.celrep.2020.108627 ◽

2021 ◽

Vol 34 (3) ◽

pp. 108627

Author(s):

Shasha Liu ◽

Yuan Liao ◽

Biao Chen ◽

Yuhai Chen ◽

Ziding Yu ◽

...

Keyword(s):

Critical Role ◽

Antiviral Immunity ◽

Innate Antiviral Immunity

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A critical role for IL‐15 in TLR‐mediated innate antiviral immunity against genital HSV‐2 infection

Immunology and Cell Biology ◽

10.1038/icb.2011.7 ◽

2011 ◽

Vol 89 (6) ◽

pp. 663-669 ◽

Cited By ~ 10

Author(s):

Amit Thatte ◽

Stephanie J DeWitte‐Orr ◽

Brian Lichty ◽

Karen L Mossman ◽

Ali A Ashkar

Keyword(s):

Critical Role ◽

Antiviral Immunity ◽

Innate Antiviral Immunity

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Dual Role of p53 in Innate Antiviral Immunity

Viruses ◽

10.3390/v2010298 ◽

2010 ◽

Vol 2 (1) ◽

pp. 298-313 ◽

Cited By ~ 60

Author(s):

Carmen Rivas ◽

Stuart A. Aaronson ◽

Cesar Munoz-Fontela

Keyword(s):

Antiviral Immunity ◽

Dual Role ◽

Innate Antiviral Immunity

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Mitophagy in Antiviral Immunity

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.723108 ◽

2021 ◽

Vol 9 ◽

Author(s):

Hongna Wang ◽

Yongfeng Zheng ◽

Jieru Huang ◽

Jin Li

Keyword(s):

Quality Control ◽

Immune System ◽

Oxidative Phosphorylation ◽

Energy Production ◽

Viral Infections ◽

Critical Role ◽

Antiviral Immunity ◽

Host Immune System ◽

Mitochondrial Quality Control

Mitochondria are important organelles whose primary function is energy production; in addition, they serve as signaling platforms for apoptosis and antiviral immunity. The central role of mitochondria in oxidative phosphorylation and apoptosis requires their quality to be tightly regulated. Mitophagy is the main cellular process responsible for mitochondrial quality control. It selectively sends damaged or excess mitochondria to the lysosomes for degradation and plays a critical role in maintaining cellular homeostasis. However, increasing evidence shows that viruses utilize mitophagy to promote their survival. Viruses use various strategies to manipulate mitophagy to eliminate critical, mitochondria-localized immune molecules in order to escape host immune attacks. In this article, we will review the scientific advances in mitophagy in viral infections and summarize how the host immune system responds to viral infection and how viruses manipulate host mitophagy to evade the host immune system.

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The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

Perspectives on Language Learning and Education ◽

10.1044/lle15.2.50 ◽

2008 ◽

Vol 15 (2) ◽

pp. 50-59 ◽

Cited By ~ 1

Author(s):

Amy Philofsky

Keyword(s):

Language Development ◽

Critical Role ◽

Children With Autism ◽

Autism Spectrum ◽

Children With Asd ◽

Prevalence Estimates ◽

Notable Increase ◽

Screening Assessment ◽

Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

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