scholarly journals Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans

Cell Reports ◽  
2020 ◽  
Vol 33 (13) ◽  
pp. 108554
Author(s):  
Thomas Morville ◽  
Ronni E. Sahl ◽  
Thomas Moritz ◽  
Jørn W. Helge ◽  
Christoffer Clemmensen
Keyword(s):  
Resistance Exercise ◽  
Endurance Exercise ◽  
Plasma Metabolome ◽  
Metabolome Profiling ◽  
Exercise In Humans

scholarly journals Skeletal Muscle Metabolomic Responses to Endurance and Resistance Training in Rats under Chronic Unpredictable Mild Stress

2021 ◽  
Vol 18 (4) ◽  
pp. 1645
Author(s):  
Xiangyu Liu ◽  
Xiong Xue ◽  
Junsheng Tian ◽  
Xuemei Qin ◽  
Shi Zhou ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Endurance Exercise ◽  
Field Tests ◽  
Treadmill Running ◽  
Control Group ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Sprague Dawley ◽  
Exercise Interventions ◽  
Sprague Dawley Rats

The objectives of this study were to compare the antidepressant effects between endurance and resistance exercise for optimizing interventions and examine the metabolomic changes in different types of skeletal muscles in response to the exercise, using a rat model of chronic unpredictable mild stress (CUMS)-induced depression. There were 32 male Sprague-Dawley rats randomly divided into a control group (C) and 3 experimental groups: CUMS control (D), endurance exercise (E), and resistance exercise (R). Group E underwent 30 min treadmill running, and group R performed 8 rounds of ladder climbing, 5 sessions per week for 4 weeks. Body weight, sucrose preference, and open field tests were performed pre and post the intervention period for changes in depressant symptoms, and the gastrocnemius and soleus muscles were sampled after the intervention for metabolomic analysis using the 1H-NMR technique. The results showed that both types of exercise effectively improved the depression-like symptoms, and the endurance exercise appeared to have a better effect. The levels of 10 metabolites from the gastrocnemius and 13 metabolites from the soleus of group D were found to be significantly different from that of group C, and both types of exercise had a callback effect on these metabolites, indicating that a number of metabolic pathways were involved in the depression and responded to the exercise interventions.

scholarly journals Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1821
Author(s):  
Ujjwal Mukund Mahajan ◽  
Ahmed Alnatsha ◽  
Qi Li ◽  
Bettina Oehrle ◽  
Frank-Ulrich Weiss ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Enrichment Analysis ◽  
Response Prediction ◽  
Ductal Adenocarcinoma ◽  
Pathway Enrichment Analysis ◽  
Metabolome Analysis ◽  
Dismal Prognosis ◽  
Chemotherapeutic Response ◽  
Plasma Metabolome ◽  
Metabolome Profiling

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Developing biomarkers for early detection and chemotherapeutic response prediction is crucial to improve the dismal prognosis of PDAC patients. However, molecular cancer signatures based on transcriptome analysis do not reflect intratumoral heterogeneity. To explore a more accurate stratification of PDAC phenotypes in an easily accessible matrix, plasma metabolome analysis using MxP® Global Profiling and MxP® Lipidomics was performed in 361 PDAC patients. We identified three metabolic PDAC subtypes associated with distinct complex lipid patterns. Subtype 1 was associated with reduced ceramide levels and a strong enrichment of triacylglycerols. Subtype 2 demonstrated increased abundance of ceramides, sphingomyelin and other complex sphingolipids, whereas subtype 3 showed decreased levels of sphingolipid metabolites in plasma. Pathway enrichment analysis revealed that sphingolipid-related pathways differ most among subtypes. Weighted correlation network analysis (WGCNA) implied PDAC subtypes differed in their metabolic programs. Interestingly, a reduced expression among related pathway genes in tumor tissue was associated with the lowest survival rate. However, our metabolic PDAC subtypes did not show any correlation to the described molecular PDAC subtypes. Our findings pave the way for further studies investigating sphingolipids metabolisms in PDAC.

scholarly journals Profiling of Circulating MicroRNAs after a Bout of Acute Resistance Exercise in Humans

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70823 ◽  
Author(s):  
Shuji Sawada ◽  
Michihiro Kon ◽  
Shogo Wada ◽  
Takashi Ushida ◽  
Katsuhiko Suzuki ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Circulating Micrornas ◽  
Exercise In Humans

Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans

2000 ◽  
Vol 278 (4) ◽  
pp. E580-E587 ◽  
Author(s):  
Scott McKenzie ◽  
Stuart M. Phillips ◽  
Sherry L. Carter ◽  
Stuart Lowther ◽  
Martin J. Gibala ◽  
...  
Keyword(s):  
Exercise Training ◽  
Endurance Exercise ◽  
Citrate Synthase ◽  
Exercise Bout ◽  
Leucine Oxidation ◽  
Endurance Exercise Training ◽  
Exercise Training Program ◽  
Activated State ◽  
Branched Chain ◽  
Exercise In Humans

We studied the effects of a 38-day endurance exercise training program on leucine turnover and substrate metabolism during a 90-min exercise bout at 60% peak O2 consumption (V˙o 2 peak) in 6 males and 6 females. Subjects were studied at both the same absolute (ABS) and relative (REL) exercise intensities posttraining. Training resulted in a significant increase in whole bodyV˙o 2 peak and skeletal muscle citrate synthase (CS; P < 0.001), complex I-III ( P < 0.05), and total branched-chain 2-oxoacid dehydrogenase (BCOAD; P < 0.001) activities. Leucine oxidation increased during exercise for the pretraining trial (PRE, P < 0.001); however, there was no increase for either the ABS or REL posttraining trial. Leucine oxidation was significantly lower for females at all time points during rest and exercise ( P < 0.01). The percentage of BCOAD in the activated state was significantly increased after exercise for both the PRE and REL exercise trials, with the increase in PRE being greater ( P < 0.001) compared with REL ( P < 0.05). Females oxidized proportionately more lipid and less carbohydrate during exercise compared with males. In conclusion, we found that 38 days of endurance exercise training significantly attenuated both leucine oxidation and BCOAD activation during 90 min of endurance exercise at 60%V˙o 2 peak for both ABS and REL exercise intensities. Furthermore, females oxidize proportionately more lipid and less carbohydrate compared with males during endurance exercise.

The Effects of Prior Resistance Exercise on Lipolysis and Fat Oxidation during Subsequent Endurance Exercise

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S545
Author(s):  
Kazushige Goto ◽  
Naokata Ishii ◽  
Shuhei Sugihara ◽  
Toshitsugu Yoshioka ◽  
Kaoru Takamatsu ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Endurance Exercise ◽  
Fat Oxidation
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