scholarly journals Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration

Cell Reports ◽  
2020 ◽  
Vol 33 (5) ◽  
pp. 108328
Author(s):  
Emma Jennings ◽  
Thomas A.E. Elliot ◽  
Natasha Thawait ◽  
Shivani Kanabar ◽  
Juan Carlos Yam-Puc ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Signal Strength ◽  
Cell Receptor ◽  
Reporter Mice ◽  
Receptor Signal

S.100. SAP Augments Proximal T Cell Receptor Signal Strength Necessary for Restimulation-induced Apoptosis of Activated T Cells

2009 ◽  
Vol 131 ◽  
pp. S160 ◽  
Author(s):  
Andrew Snow ◽  
Rebecca Marsh ◽  
Scott Krummey ◽  
Philip Roehrs ◽  
Kejian Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Signal Strength ◽  
Cell Receptor ◽  
Activated T Cells ◽  
Receptor Signal ◽  
S 100 ◽  
Induced Apoptosis

scholarly journals Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo

Cell Reports ◽  
2021 ◽  
Vol 35 (10) ◽  
pp. 109227
Author(s):  
Edward L.Y. Chen ◽  
Christina R. Lee ◽  
Patrycja K. Thompson ◽  
David L. Wiest ◽  
Michele K. Anderson ◽  
...  
Keyword(s):  
T Cell ◽  
Notch Signaling ◽  
T Cell Receptor ◽  
Signal Strength ◽  
Cell Receptor ◽  
Functional Differentiation ◽  
Γδ T Cell ◽  
Receptor Signal

scholarly journals Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength

Immunity ◽  
2021 ◽  
Author(s):  
Thomas A.E. Elliot ◽  
Emma K. Jennings ◽  
David A.J. Lecky ◽  
Natasha Thawait ◽  
Adriana Flores-Langarica ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Signal Strength ◽  
Cell Receptor ◽  
Receptor Signal

scholarly journals T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate

2019 ◽  
Vol 27 (4) ◽  
pp. 1214-1224 ◽  
Author(s):  
Kun-Po Li ◽  
Brian H. Ladle ◽  
Sema Kurtulus ◽  
Allyson Sholl ◽  
Sharmila Shanmuganad ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Fate ◽  
T Cell Receptor ◽  
Memory T Cells ◽  
Signal Strength ◽  
Cd8 T Cell ◽  
Cell Receptor ◽  
Receptor Signal ◽  
The Many

Abstract Most effector CD8+ T cells die, while some persist and become either “effector” (TEM) or “central” (TCM) memory T cells. Paradoxically, effector CD8+ T cells with greater memory potential have higher levels of the pro-apoptotic molecule Bim. Here, we report, using a novel Bim-mCherry knock-in mouse, that cells with high levels of Bim preferentially develop into TCM cells. Bim levels remained stable and were regulated by DNA methylation at the Bim promoter. Notably, high levels of Bcl-2 were required for Bimhi cells to survive. Using Nur77-GFP mice as an indicator of TCR signal strength, Nur77 levels correlated with Bim expression and Nur77hi cells also selectively developed into TCM cells. Altogether, these data show that Bim levels and TCR signal strength are predictive of TEM- vs. TCM-cell fate. Further, given the many other biologic functions of Bim, these mice will have broad utility beyond CD8+ T-cell fate.

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