scholarly journals Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2+ Granule Neuron Precursor

Cell Reports ◽  
2020 ◽  
Vol 31 (2) ◽  
pp. 107511 ◽  
Author(s):  
Hayden J. Selvadurai ◽  
Erika Luis ◽  
Kinjal Desai ◽  
Xiaoyang Lan ◽  
Maria C. Vladoiu ◽  
...  
Keyword(s):  
Granule Neuron ◽  
Neuron Precursor

scholarly journals 2,3,7,8-Tetracholorodibenzo-p-Dioxin Exposure Disrupts Granule Neuron Precursor Maturation in the Developing Mouse Cerebellum

2008 ◽  
Vol 103 (1) ◽  
pp. 125-136 ◽  
Author(s):  
Loretta L. Collins ◽  
Mary A. Williamson ◽  
Bryan D. Thompson ◽  
Daniel P. Dever ◽  
Thomas A. Gasiewicz ◽  
...  
Keyword(s):  
Granule Neuron ◽  
Mouse Cerebellum ◽  
Dioxin Exposure ◽  
Neuron Precursor

Granule neuron precursor cell proliferation is regulated by NFIX and intersectin 1 during postnatal cerebellar development

2018 ◽  
Vol 224 (2) ◽  
pp. 811-827 ◽  
Author(s):  
James Fraser ◽  
Alexandra Essebier ◽  
Alexander S. Brown ◽  
Raul Ayala Davila ◽  
Ameet S. Sengar ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Precursor Cell ◽  
Cerebellar Development ◽  
Granule Neuron ◽  
Neuron Precursor

scholarly journals Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

Cancer Cell ◽  
2008 ◽  
Vol 14 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Ulrich Schüller ◽  
Vivi M. Heine ◽  
Junhao Mao ◽  
Alvin T. Kho ◽  
Allison K. Dillon ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Critical Determinant ◽  
Granule Neuron ◽  
Cell Competence ◽  
Neuron Precursor

scholarly journals Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

2021 ◽  
Author(s):  
Odessa R. Yabut ◽  
Hector Gomez ◽  
Jessica Arela ◽  
Jesse Garcia Castillo ◽  
Thomas Ngo ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Dna Lesions ◽  
Fgf Signaling ◽  
Loss Of Function ◽  
Direct Inhibition ◽  
Granule Neuron ◽  
Shh Pathway ◽  
Suppressor Of Fused ◽  
Granule Neuron Precursors ◽  
Neuron Precursor

Mutations in Sonic Hedgehog (SHH) signaling pathway genes, e.g. Suppressor of Fused (SUFU), drive granule neuron precursors (GNP) to form medulloblastomas (MBSHH). However, how different molecular lesions in the Shh pathway drive transformation is frequently unclear, and in particular, SUFU mutations in the cerebellum seem distinct. In this study, we show that fibroblast growth factor 5 (FGF5) signaling is integral for many infantile MBSHH cases. We found that FGF5 expression is uniquely upregulated in infantile MBSHH tumors. Also, in mice carrying loss-of-function SUFU mutations (Sufu-cKO), FGF5 is ectopically expressed specifically along the secondary fissure where GNPs harboring preneoplastic DNA lesions are massively expanded and FGFR signaling is also ectopically activated in this region. Treatment with an FGFR antagonist rescues the severe GNP hyperplasia and restores cerebellar architecture. Thus, direct inhibition of FGF signaling may be a promising and novel therapeutic candidate for infantile MBSHH.

scholarly journals BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0156907 ◽  
Author(s):  
Gregory M. Shackleford ◽  
Xiang-He Shi ◽  
Kimberly S. Swanson ◽  
Min Y. Mahdi ◽  
Ignacio Gonzalez-Gomez ◽  
...  
Keyword(s):  
Mouse Model ◽  
Granule Neuron ◽  
Neuron Precursor

scholarly journals An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation

2012 ◽  
Vol 123 (4) ◽  
pp. 573-586 ◽  
Author(s):  
Cemile G. Guldal ◽  
Adiba Ahmad ◽  
Andrey Korshunov ◽  
Massimo Squatrito ◽  
Aashir Awan ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Essential Role ◽  
Cerebellar Granule Neuron ◽  
Cerebellar Granule ◽  
Granule Neuron ◽  
Neuron Precursor
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