scholarly journals NvPOU4/Brain3 Functions as a Terminal Selector Gene in the Nervous System of the Cnidarian Nematostella vectensis

Cell Reports ◽  
2020 ◽  
Vol 30 (13) ◽  
pp. 4473-4489.e5 ◽  
Author(s):  
Océane Tournière ◽  
David Dolan ◽  
Gemma Sian Richards ◽  
Kartik Sunagar ◽  
Yaara Y. Columbus-Shenkar ◽  
...  
Keyword(s):  
Nervous System ◽  
Nematostella Vectensis ◽  
Cnidarian Nematostella Vectensis

scholarly journals Aryl hydrocarbon receptor (AHR) in the cnidarian Nematostella vectensis: comparative expression, protein interactions, and ligand binding

2013 ◽  
Vol 224 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Adam M. Reitzel ◽  
Yale J. Passamaneck ◽  
Sibel I. Karchner ◽  
Diana G. Franks ◽  
Mark Q. Martindale ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Aryl Hydrocarbon Receptor ◽  
Protein Interactions ◽  
Nematostella Vectensis ◽  
Aryl Hydrocarbon ◽  
Cnidarian Nematostella Vectensis

scholarly journals Antagonistic BMP–cWNT signaling in the cnidarian Nematostella vectensis reveals insight into the evolution of mesoderm

2017 ◽  
Vol 114 (28) ◽  
pp. E5608-E5615 ◽  
Author(s):  
Naveen Wijesena ◽  
David K. Simmons ◽  
Mark Q. Martindale
Keyword(s):  
Cell Fate ◽  
Target Genes ◽  
Bmp Signaling ◽  
Nematostella Vectensis ◽  
Beta Catenin ◽  
Molecular Signaling ◽  
Downstream Target ◽  
Evolutionary Innovation ◽  
Morphogenetic Protein ◽  
Cnidarian Nematostella Vectensis

Gastrulation was arguably the key evolutionary innovation that enabled metazoan diversification, leading to the formation of distinct germ layers and specialized tissues. Differential gene expression specifying cell fate is governed by the inputs of intracellular and/or extracellular signals. Beta-catenin/Tcf and the TGF-beta bone morphogenetic protein (BMP) provide critical molecular signaling inputs during germ layer specification in bilaterian metazoans, but there has been no direct experimental evidence for a specific role for BMP signaling during endomesoderm specification in the early branching metazoan Nematostella vectensis (an anthozoan cnidarian). Using forward transcriptomics, we show that beta-catenin/Tcf signaling and BMP2/4 signaling provide differential inputs into the cnidarian endomesodermal gene regulatory network (GRN) at the onset of gastrulation (24 h postfertilization) in N. vectensis. Surprisingly, beta-catenin/Tcf signaling and BMP2/4 signaling regulate a subset of common downstream target genes in the GRN in opposite ways, leading to the spatial and temporal differentiation of fields of cells in the developing embryo. Thus, we show that regulatory interactions between beta-catenin/Tcf signaling and BMP2/4 signaling are required for the specification and determination of different embryonic regions and the patterning of the oral–aboral axis in Nematostella. We also show functionally that the conserved “kernel” of the bilaterian heart mesoderm GRN is operational in N. vectensis, which reinforces the hypothesis that the endoderm and mesoderm in triploblastic bilaterians evolved from the bifunctional endomesoderm (gastrodermis) of a diploblastic ancestor, and that slow rhythmic contractions might have been one of the earliest functions of mesodermal tissue.

scholarly journals Wnt signaling in the cnidarian Nematostella vectensis: Insights into the evolution of gastrulation

2011 ◽  
Vol 356 (1) ◽  
pp. 107 ◽  
Author(s):  
Naveen M. Wijesena ◽  
Shalika Kumburegama ◽  
Ronghui Xu ◽  
Athula Wikramanayake
Keyword(s):  
Wnt Signaling ◽  
Nematostella Vectensis ◽  
Cnidarian Nematostella Vectensis
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