scholarly journals BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin

Cell Reports ◽  
2020 ◽  
Vol 30 (12) ◽  
pp. 4292-4302.e7
Author(s):  
Rita Mateus ◽  
Laurent Holtzer ◽  
Carole Seum ◽  
Zena Hadjivasiliou ◽  
Marine Dubois ◽  
...  
Keyword(s):  
Bmp Signaling ◽  
Pectoral Fin ◽  
Gradient Scaling

scholarly journals Scale invariance of BMP signaling gradients in zebrafish

2018 ◽  
Author(s):  
Yan Huang ◽  
David Umulis
Keyword(s):  
Scale Invariance ◽  
Bmp Signaling ◽  
Spatial Patterning ◽  
Protein Signaling ◽  
Wild Type ◽  
Bone Morphogenetic Protein Signaling ◽  
Cross Sectional ◽  
Morphogenetic Protein ◽  
Core Questions ◽  
Gradient Scaling

In both vertebrates and invertebrates, spatial patterning along the Dorsal-ventral (DV) embryonic axis depends on a morphogen gradient of Bone Morphogenetic Protein signaling. Scale invariance of DV patterning by BMPs has been found in both vertebrates and invertebrates, however the mechanisms that regulate gradient scaling remain controversial. To obtain quantitative data that can be used to address core questions of scaling, we introduce a method to tune the size of zebrafish embryos by reducing varying amounts of vegetal yolk. We quantified the BMP signaling gradient in wild-type and perturbed embryos and found that the system scales for reductions in cross-sectional perimeter of up to 30%. Furthermore, we found that the degree of scaling for intraspecies scaling within zebrafish is greater than that between Danioninae species.

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