scholarly journals Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor

Cell Reports ◽  
2020 ◽  
Vol 30 (2) ◽  
pp. 541-554.e5 ◽  
Author(s):  
Karyn Schmidt ◽  
Chase A. Weidmann ◽  
Thomas A. Hilimire ◽  
Elaine Yee ◽  
Breanne M. Hatfield ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Specific Binding ◽  
Its Sequence ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR)

2017 ◽  
Vol 43 (1) ◽  
pp. 405-418 ◽  
Author(s):  
Yaoyao Xiong ◽  
Long Wang ◽  
Yuan Li ◽  
Minfeng Chen ◽  
Wei He ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Cancer Growth ◽  
Invasion And Migration ◽  
Non Coding Rna ◽  
Bladder Cancer Cells ◽  
And Migration ◽  
Cancer Tissues ◽  
Long Non Coding Rna

Backgrounds/Aims: Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA’s target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR) is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. Methods: XIST and AR expression was detected in bladder tumor samples and cell lines. Effects of XIST and AR on bladder cancer cells growth, invasion and migration were analyzed. Bioinformatic analysis and luciferase assays were used to identify the interaction among XIST, AR and miR-124. The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed. Results: XIST and AR were upregulated in bladder cancer tissues and positively correlated. Higher XIST and AR expression were related to poorer TNM stage of bladder cancer. XIST knockdown reduced bladder cancer cells’ proliferation, invasion and migration. While this inhibitory effect could be partially restored by AR overexpression. XIST inhibited miR-124 expression by directly targeting. Moreover, miR-124 could bind to the 3’UTR of AR to regulate its expression. MiR-124 inhibition partially restored the XIST knockdown-induced reduction of AR, c-myc, p27, MMP13 and MMP9 expression. In bladder cancer tissues, miR-124 level was inversely correlated with the expression of XIST and AR, respectively. Conclusion: These findings indicated that XIST might be an oncogenic lncRNA that promoted the bladder cancer growth, invasion and migration via miR-124 dependent AR regulation.

scholarly journals A role for YY1 in sex-biased transcription revealed through X-linked promoter activity and allelic binding analyses

2016 ◽  
Author(s):  
Chih-yu Chen ◽  
Wenqiang Shi ◽  
Allison M. Matthews ◽  
Yifeng Li ◽  
David J. Arenillas ◽  
...  
Keyword(s):  
X Chromosome ◽  
Specific Binding ◽  
Positive Association ◽  
Binding Motif ◽  
Transcription Start ◽  
Transcription Factor Binding Motif ◽  
Transcription Start Sites ◽  
Non Coding Rna ◽  
Allelic Gene ◽  
Long Non Coding Rna

AbstractSex differences in susceptibility and progression have been reported in numerous diseases. Female cells have two copies of the X chromosome with X-chromosome inactivation imparting mono-allelic gene silencing for dosage compensation. However, a subset of genes, named escapees, escape silencing and are transcribed bi-allelically resulting in sexual dimorphism. Here we conducted analyses of the sexes using human datasets to gain perspectives in such regulation. We identified transcription start sites of escapees (escTSSs) based on higher transcription levels in female cells using FANTOM5 CAGE data. Significant over-representations of YY1 transcription factor binding motif and ChIP-seq peaks around escTSSs highlighted its positive association with escapees. Furthermore, YY1 occupancy is significantly biased towards the inactive X (Xi) at long non-coding RNA loci that are frequent contacts of Xi-specific superloops. Our study elucidated the importance of YY1 on transcriptional activity on Xi in general through sequence-specific binding, and its involvement at superloop anchors.

Abstract 983: Integrative analysis of androgen receptor regulated long non-coding RNA in prostate cancer

2016 ◽  
Author(s):  
Rohit Malik ◽  
Yajia Zhang ◽  
Marcin Cieslik ◽  
Yashar S. Niknafs ◽  
Sethuramasundaram Pitchiaya ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Integrative Analysis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA regulating androgen receptor signaling in breast and prostate cancer

2021 ◽  
Vol 504 ◽  
pp. 15-22
Author(s):  
Shashank Kumar ◽  
Kumari Sunita Prajapati ◽  
Atul Kumar Singh ◽  
Prem Prakash Kushwaha ◽  
Mohd Shuaib ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Signaling ◽  
Androgen Receptor Signaling ◽  
Non Coding Rna ◽  
Breast And Prostate Cancer ◽  
Long Non Coding Rna

A novel long non-coding RNA PCLN16 facilitates androgen receptor signaling in prostate cancer

2021 ◽  
Vol 537 ◽  
pp. 78-84
Author(s):  
Zhenfeng Shi ◽  
Jie Chen ◽  
Aikebaier Wumaner ◽  
Ming Li ◽  
Chengyuan Liang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Signaling ◽  
Androgen Receptor Signaling ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract 2549: A long non-coding RNA regulates the androgen receptor and mediates prostate cancer progression

2017 ◽  
Author(s):  
Sethuramasundaram Pitchiaya ◽  
Rohit Malik ◽  
Marcin Cieslik ◽  
Yajia Zhang ◽  
Xia Jiang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Transcriptional role of androgen receptor in the expression of long non-coding RNA Sox2OT in neurogenesis

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180579 ◽  
Author(s):  
Valentina Tosetti ◽  
Jenny Sassone ◽  
Anna L. M. Ferri ◽  
Michela Taiana ◽  
Gloria Bedini ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo

2015 ◽  
Vol 14 (1) ◽  
pp. 46 ◽  
Author(s):  
Abhijit Parolia ◽  
Francesco Crea ◽  
Hui Xue ◽  
Yuwei Wang ◽  
Fan Mo ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Activity ◽  
Non Coding Rna ◽  
Androgen Receptor Activity ◽  
Long Non Coding Rna
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