scholarly journals S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches

Cell Reports ◽  
2019 ◽  
Vol 29 (9) ◽  
pp. 2823-2834.e7 ◽  
Author(s):  
Kazufumi Kunimura ◽  
Daiji Sakata ◽  
Xin Tun ◽  
Takehito Uruno ◽  
Miho Ushijima ◽  
...  
Keyword(s):  
Peyer's Patches ◽  
Peyer’S Patches ◽  
S100a4 Protein ◽  
Microfold Cells

scholarly journals The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

2019 ◽  
Vol 10 ◽  
Author(s):  
Nobuhide Kobayashi ◽  
Daisuke Takahashi ◽  
Shunsuke Takano ◽  
Shunsuke Kimura ◽  
Koji Hase
Keyword(s):  
Immune System ◽  
Autoimmune Diseases ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Gut Immune System ◽  
Microfold Cells

Abstract 26: Stroke Impairs Epithelial Microfold Cells in Intestinal Peyer’s Patches

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Juneyoung Lee ◽  
Yun-Ju Lai ◽  
Louise D McCullough ◽  
Venugopal R Venna
Keyword(s):  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Microfold Cells

scholarly journals Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer’s patches

2021 ◽  
Vol 7 (20) ◽  
pp. eabf0677
Author(s):  
Sisi Lin ◽  
Subhajit Mukherjee ◽  
Juanjuan Li ◽  
Weiliang Hou ◽  
Chao Pan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Bacterial Translocation ◽  
Mucosal Immunity ◽  
Oral Delivery ◽  
Immunoglobulin A ◽  
Intestinal Barrier ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
External Threats ◽  
Microfold Cells

Methods capable of maintaining gut microbiota homeostasis to prevent bacterial translocation and infection under external threats are critical for multiple facets of human health but have been rarely reported. Here, we describe the elicitation of mucosal immunity to modulate the gut microbiota by oral delivery of living probiotics into Peyer’s patches. Probiotics are individually camouflaged within a yeast membrane, on which the embedded β-glucan can facilitate the phagocytosis of microfold cells that locate in the intestinal epithelium. The delivery of probiotics into lymphoid follicles after oral ingestion promotes robust mucosal immune responses and notably upgrades the production of secretory immunoglobulin A. The provoked immunity positively regulates the gut microflora, which, in turn, retains gut homeostasis and provides defense against environmental attacks. In two murine models of gut barrier impairment, oral administration with camouflaged probiotics effectively prevents the breakdown of intestinal barrier and evidences limited bacterial translocation and systemic inflammation.

Post-mortem Peyer’s patches: Their potential application in forensic medicine

2009 ◽  
Vol 00 (00) ◽  
pp. 090513010017019-7
Author(s):  
Biagio Solarino ◽  
Giancarlo Di Vella ◽  
Thea Magrone ◽  
Felicita Jirillo ◽  
Angela Tafaro ◽  
...  
Keyword(s):  
Forensic Medicine ◽  
Potential Application ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Post Mortem
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