scholarly journals Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces during Intravascular Arrest

Cell Reports ◽  
2019 ◽  
Vol 28 (10) ◽  
pp. 2491-2500.e5 ◽  
Author(s):  
Naël Osmani ◽  
Gautier Follain ◽  
María J. García León ◽  
Olivier Lefebvre ◽  
Ignacio Busnelli ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Metastatic Tumor ◽  
Shear Forces

scholarly journals Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces During Intravascular Arrest

2019 ◽  
Author(s):  
Nael Osmani ◽  
Gautier Follain ◽  
Maria Jesus Garcia-Leon ◽  
Olivier Lefebvre ◽  
Ignacio Busnelli ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Metastatic Tumor ◽  
Shear Forces

scholarly journals Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest

2018 ◽  
Author(s):  
Naël Osmani ◽  
Gautier Follain ◽  
Marìa Jesùs Garcia Leòn ◽  
Olivier Lefebvre ◽  
Ignacio Busnelli ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Flow ◽  
Tumor Cells ◽  
Cancer Metastasis ◽  
Integrin Αvβ3 ◽  
Metastatic Tumor ◽  
Shear Forces ◽  
Integrin Α5β1 ◽  
Lower Shear ◽  
Cell Adhesive

SUMMARYCancer metastasis is a process whereby a primary tumor spreads to distant organs. We have previously demonstrated that blood flow controls the intravascular arrest of circulating tumor cells (CTCs), through stable adhesion to endothelial cells. We now aim at defining the contribution of cell adhesive potential and at identifying adhesion receptors at play. Early arrest is mediated by the formation of weak adhesion depending on CD44 and integrin αvβ3. Stabilization of this arrest uses integrin α5β1-dependent adhesions with higher adhesion strength, which allows CTCs to stop in vascular regions with lower shear forces. Moreover, blood flow favors luminal deposition of fibronectin on endothelial cells, an integrin α5β1 ligand. Finally, we show that only receptors involved in stable adhesion are required for subsequent extravasation and metastasis. In conclusion, we identified the molecular partners that are sequentially exploited by CTCs to arrest and extravasate in vascular regions with permissive flow regimes.

scholarly journals The dynamic behavior of lipid droplets in the pre-metastatic niche

2020 ◽  
Vol 11 (11) ◽  
Author(s):  
Chunliang Shang ◽  
Jie Qiao ◽  
Hongyan Guo
Keyword(s):  
Tumor Cells ◽  
Immune Cells ◽  
Stromal Cells ◽  
Lipid Droplets ◽  
Metastatic Tumor ◽  
Current Evidence ◽  
Biological Functions ◽  
Metastatic Niche ◽  
Niche Formation

AbstractThe pre-metastatic niche is a favorable microenvironment for the colonization of metastatic tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or adiposomes) have increasingly been recognized as lipid-rich, functionally dynamic organelles within tumor cells, immune cells, and other stromal cells that are linked to diverse biological functions and human diseases. Moreover, in recent years, several studies have described the indispensable role of LDs in the development of pre-metastatic niches. This review discusses current evidence related to the biogenesis, composition, and functions of LDs related to the following characteristics of the pre-metastatic niche: immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, reprogramming. We also address the function of LDs in mediating pre-metastatic niche formation. The potential of LDs as markers and targets for novel antimetastatic therapies will be discussed.

scholarly journals Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth

2021 ◽  
Vol 22 (6) ◽  
pp. 2911
Author(s):  
Lauren M. Kreps ◽  
Christina L. Addison
Keyword(s):  
Tumor Cells ◽  
Metastatic Tumor ◽  
Disseminated Tumor Cells ◽  
Tumour Mass ◽  
Cellular Interactions ◽  
Bone Microenvironment ◽  
Cell Functions ◽  
Immunosuppressive Cell ◽  
Metastatic Microenvironment ◽  
Complex Relationships

Metastasis to the bone is a common feature of many cancers including those of the breast, prostate, lung, thyroid and kidney. Once tumors metastasize to the bone, they are essentially incurable. Bone metastasis is a complex process involving not only intravasation of tumor cells from the primary tumor into circulation, but extravasation from circulation into the bone where they meet an environment that is generally suppressive of their growth. The bone microenvironment can inhibit the growth of disseminated tumor cells (DTC) by inducing dormancy of the DTC directly and later on following formation of a micrometastatic tumour mass by inhibiting metastatic processes including angiogenesis, bone remodeling and immunosuppressive cell functions. In this review we will highlight some of the mechanisms mediating DTC dormancy and the complex relationships which occur between tumor cells and bone resident cells in the bone metastatic microenvironment. These inter-cellular interactions may be important targets to consider for development of novel effective therapies for the prevention or treatment of bone metastases.

scholarly journals Bone tumor-targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells

2020 ◽  
pp. 100088
Author(s):  
Robin A. Nadar ◽  
Gerben M. Franssen ◽  
Natasja W.M. Van Dijk ◽  
Karlijn Codee-van der Schilden ◽  
Mirjam de Weijert ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Bone Tumor ◽  
Targeted Delivery ◽  
Metastatic Tumor

Co-operation between metastatic tumor cells and macrophages in the degradation of basement membrane (type IV) collagen

FEBS Letters ◽  
1983 ◽  
Vol 161 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Nicole Henry ◽  
Yves Eeckhout ◽  
Anne-Louise van Lamsweerde ◽  
Gilbert Vaes
Keyword(s):  
Basement Membrane ◽  
Tumor Cells ◽  
Type Iv Collagen ◽  
Metastatic Tumor ◽  
Type Iv ◽  
Membrane Type
Sign in / Sign up

Export Citation Format

Share Document