scholarly journals Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

Cell Reports ◽  
2019 ◽  
Vol 28 (9) ◽  
pp. 2455-2470.e5 ◽  
Author(s):  
Myles J. Lewis ◽  
Michael R. Barnes ◽  
Kevin Blighe ◽  
Katriona Goldmann ◽  
Sharmila Rana ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Response ◽  
Early Rheumatoid Arthritis

scholarly journals Immune response profiling in early rheumatoid arthritis: discovery of a novel interaction of treatment response with viral immunity

2013 ◽  
Vol 15 (6) ◽  
Author(s):  
John M Davis ◽  
Keith L Knutson ◽  
Michael A Strausbauch ◽  
Abigail B Green ◽  
Cynthia S Crowson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Response ◽  
Treatment Response ◽  
Early Rheumatoid Arthritis ◽  
Viral Immunity

scholarly journals Serum cotinine as a biomarker of tobacco exposure and the association with treatment response in early rheumatoid arthritis

2012 ◽  
Vol 64 (12) ◽  
pp. 1804-1810 ◽  
Author(s):  
Leann B. Maska ◽  
Harlan R. Sayles ◽  
James R. O'Dell ◽  
Jeffrey R. Curtis ◽  
S. Louis Bridges ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Response ◽  
Early Rheumatoid Arthritis ◽  
Tobacco Exposure ◽  
Serum Cotinine

scholarly journals Autoantibody status is not associated with early treatment response to first-line methotrexate in patients with early rheumatoid arthritis

Rheumatology ◽  
2018 ◽  
Vol 58 (1) ◽  
pp. 149-153 ◽  
Author(s):  
Jacqueline S Dekkers ◽  
Sytske Anne Bergstra ◽  
Arvind Chopra ◽  
Mohammed Tikly ◽  
João Eurico Fonseca ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Response ◽  
Early Rheumatoid Arthritis ◽  
Early Treatment ◽  
First Line ◽  
Early Treatment Response ◽  
Autoantibody Status

scholarly journals Clusterin serum levels are elevated in patients with early rheumatoid arthritis and predict disease activity and treatment response

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tereza Kropáčková ◽  
Heřman Mann ◽  
Olga Růžičková ◽  
Olga Šléglová ◽  
Lucia Vernerová ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Treatment Response ◽  
Early Rheumatoid Arthritis ◽  
Roc Analysis ◽  
Predictive Biomarker ◽  
Serum Levels ◽  
Serum Concentrations ◽  
Low Disease Activity ◽  
Treatment Naïve

AbstractClusterin (CLU) is a molecular chaperone that participates in a variety of biological processes. Recent studies indicate its possible involvement in the development of bone erosions and autoimmunity. The aim of this study was to investigate its serum concentrations in patients with early rheumatoid arthritis (RA) and to explore their potential relationship with disease activity and treatment response. Serum levels of CLU were measured in 52 patients before and 3 months after the initiation of treatment and in 52 healthy individuals. CLU levels at baseline were significantly increased in patients with early RA compared with healthy subjects (p < 0.0001). After 3 months of treatment, the levels of CLU decreased and reached concentrations comparable to those in controls. Even though there was no relationship between CLU levels and disease activity at baseline, CLU levels positively correlated with disease activity at months 3, 6 and 12 after treatment initiation. Using ROC analysis, lower CLU baseline levels predicted achieving the therapeutic target of low disease activity and remission at months 3, 6 and 12. In summary, we found increased serum concentrations of clusterin in treatment-naïve patients with early rheumatoid arthritis, and we suggest clusterin as a predictive biomarker of disease activity and treatment response.

scholarly journals MicroRNA-125b: association with disease activity and the treatment response of patients with early rheumatoid arthritis

2016 ◽  
Vol 18 (1) ◽  
Author(s):  
Veronika Hruskova ◽  
Romana Jandova ◽  
Lucia Vernerova ◽  
Herman Mann ◽  
Ondrej Pecha ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Treatment Response ◽  
Early Rheumatoid Arthritis

scholarly journals The effect on treatment response of fibromyalgic symptoms in early rheumatoid arthritis patients: results from the ESPOIR cohort

Rheumatology ◽  
2017 ◽  
Vol 56 (7) ◽  
pp. 1244-1244
Author(s):  
Josefina Durán ◽  
Bernard Combe ◽  
Jingbo Niu ◽  
Nathalie Rincheval ◽  
Cécile Gaujoux-Viala ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Response ◽  
Early Rheumatoid Arthritis

Adding baseline protein biomarkers to clinical predictors does not enhance prediction of treatment response to a methotrexate strategy in early rheumatoid arthritis

2018 ◽  
Vol 78 (1) ◽  
pp. 142-144 ◽  
Author(s):  
Xavier M Teitsma ◽  
Johannes W G Jacobs ◽  
Pascal H P de Jong ◽  
Johanna M W Hazes ◽  
Angelique E A M Weel ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Response ◽  
Early Rheumatoid Arthritis ◽  
Protein Biomarkers ◽  
Clinical Predictors
Sign in / Sign up

Export Citation Format

Share Document