Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease

Silvia Ciappelloni; Delphine Bouchet; Nadège Dubourdieu; Eric Boué-Grabot; Blanka Kellermayer; Constance Manso; Romain Marignier; Stéphane H.R. Oliet; Thomas Tourdias; Laurent Groc

doi:10.1016/j.celrep.2019.05.097

Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease

Cell Reports ◽

10.1016/j.celrep.2019.05.097 ◽

2019 ◽

Vol 27 (13) ◽

pp. 3860-3872.e4 ◽

Cited By ~ 3

Author(s):

Silvia Ciappelloni ◽

Delphine Bouchet ◽

Nadège Dubourdieu ◽

Eric Boué-Grabot ◽

Blanka Kellermayer ◽

...

Keyword(s):

Autoimmune Disease ◽

Synaptic Activity ◽

Aquaporin 4 ◽

Astrocytic Process

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Laryngeal Manifestations of Autoimmune Diseases

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2020_persp-19-00168 ◽

2020 ◽

Vol 5 (2) ◽

pp. 439-456

Author(s):

Jenny L. Pierce

Keyword(s):

Autoimmune Disease ◽

Autoimmune Diseases ◽

Patient Outcomes ◽

Correct Diagnosis ◽

Upper Airway ◽

Clinical Implications ◽

Laryngeal Function ◽

The Past ◽

Referral Practices ◽

Timely Referral

Purpose This review article provides an overview of autoimmune diseases and their effects on voice and laryngeal function. Method A literature review was conducted in PubMed. Combinations of the following keywords were used: “autoimmune disease and upper airway,” “larynx,” “cough,” “voice,” “dysphonia,” and “dyspnea.” Precedence was given to articles published in the past 10 years due to recent advances in this area and to review articles. Ultimately, 115 articles were included for review. Results Approximately 81 autoimmune diseases exist, with 18 of those highlighted in the literature as having laryngeal involvement. The general and laryngeal manifestations of these 18 are discussed in detail, in addition to the clinical implications for a laryngeal expert. Conclusions Voice, breathing, and cough symptoms may be an indication of underlying autoimmune disease. However, these symptoms are often similar to those in the general population. Appropriate differential diagnosis and timely referral practices maximize patient outcomes. Guidelines are provided to facilitate correct diagnosis when an autoimmune disease is suspected.

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