scholarly journals Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75

Cell Reports ◽  
2018 ◽  
Vol 25 (13) ◽  
pp. 3573-3581.e4 ◽  
Author(s):  
Manuela D’Eletto ◽  
Federica Rossin ◽  
Luca Occhigrossi ◽  
Maria Grazia Farrace ◽  
Danilo Faccenda ◽  
...  
Keyword(s):  
Contact Sites ◽  
Transglutaminase Type 2

Herpesvirus Infections and Transglutaminase Type 2 Antibody Positivity in Childhood

2016 ◽  
Vol 63 (4) ◽  
pp. 423-430 ◽  
Author(s):  
Michelle A.E. Jansen ◽  
Diana van den Heuvel ◽  
Kirsten V.M. van der Zwet ◽  
Vincent W.V. Jaddoe ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Transglutaminase Type 2 ◽  
Antibody Positivity

scholarly journals Transglutaminase type 2: A multifunctional protein chaperone?

2014 ◽  
Vol 1 (4) ◽  
pp. e968506 ◽  
Author(s):  
Federica Rossin ◽  
Manuela D’Eletto ◽  
Maria Grazia Farrace ◽  
Mauro Piacentini
Keyword(s):  
Multifunctional Protein ◽  
Transglutaminase Type 2 ◽  
Protein Chaperone

Usefulness of tissue transglutaminase type 2 antibodies in early pregnancy

2012 ◽  
Vol 34 (6) ◽  
pp. 932-936 ◽  
Author(s):  
Maria Elisabetta Baldassarre ◽  
Annamaria Laneve ◽  
Antonietta Fontana ◽  
Fabio Manca ◽  
Gennaro Salvia ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Tissue Transglutaminase ◽  
Transglutaminase Type 2

scholarly journals Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions

2016 ◽  
Vol 1863 (8) ◽  
pp. 2084-2092 ◽  
Author(s):  
Laura Diaz-Hidalgo ◽  
Sara Altuntas ◽  
Federica Rossin ◽  
Manuela D'Eletto ◽  
Claudia Marsella ◽  
...  
Keyword(s):  
Transglutaminase Type 2

scholarly journals Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed βH-Crystallins Polymerization in Calcium-Induced Experimental Cataract

2020 ◽  
Vol 21 (15) ◽  
pp. 5427
Author(s):  
Carlo Mischiati ◽  
Giordana Feriotto ◽  
Claudio Tabolacci ◽  
Fabio Domenici ◽  
Sonia Melino ◽  
...  
Keyword(s):  
Present Report ◽  
Lens Crystallins ◽  
Lens Opacification ◽  
Transglutaminase Type 2 ◽  
Potential Formation ◽  
Cross Links ◽  
Potential Strategy ◽  
Rabbit Lens

In an in vitro Ca2+-induced cataract model, the progression of opacification is paralleled by a rapid decrease of the endogenous levels of spermidine (SPD) and an increase of transglutaminase type 2 (TG2, EC 2.3.2.13)-catalyzed lens crystallins cross-linking by protein-bound N1-N8-bis(γ-glutamyl) SPD. This pattern was reversed adding exogenous SPD to the incubation resulting in a delayed loss of transparency of the rabbit lens. The present report shows evidence on the main incorporation of SPD by the catalytic activity of TG2, toward βH-crystallins and in particular to the βB2- and mostly in βB3-crystallins. The increase of endogenous SPD in the cultured rabbit lens showed the activation of a flavin adenine dinucleotide (FAD)-dependent polyamine oxidases (PAO EC 1.5.3.11). As it is known that FAD-PAO degrades the N8-terminal reactive portion of N1-mono(γ-glutamyl) SPD, the protein-bound N8-mono(γ-glutamyl) SPD was found the mainly available derivative for the potential formation of βB3-crystallins cross-links by protein-bound N1-N8-bis(γ-glutamyl)SPD. In conclusion, FAD-PAO degradation of the N8-terminal reactive residue of the crystallins bound N1-mono(γ-glutamyl)SPD together with the increased concentration of exogenous SPD, leading to saturation of glutamine residues on the substrate proteins, drastically reduces N1-N8-bis(γ-glutamyl)SPD crosslinks formation, preventing crystallins polymerization and avoiding rabbit lens opacification. The ability of SPD and MDL 72527 to modulate the activities of TG2 and FAD-PAO involved in the mechanism of lens opacification suggests a potential strategy for the prevention of senile cataract.

Generation R birth cohort study shows that specific enamel defects were not associated with elevated serum transglutaminase type 2 antibodies

2016 ◽  
Vol 105 (10) ◽  
pp. e485-e491 ◽  
Author(s):  
Sytske A. Beth ◽  
Michelle A. E. Jansen ◽  
Maria E. C. Elfrink ◽  
Jessica C. Kiefte-de Jong ◽  
Eppo B. Wolvius ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Elevated Serum ◽  
Birth Cohort Study ◽  
Enamel Defects ◽  
Transglutaminase Type 2

scholarly journals Strategies towards in vivo imaging of active transglutaminase type 2 using positron emission tomography

Amino Acids ◽  
2016 ◽  
Vol 49 (3) ◽  
pp. 585-595 ◽  
Author(s):  
Berend van der Wildt ◽  
Adriaan A. Lammertsma ◽  
Benjamin Drukarch ◽  
Albert D. Windhorst
Keyword(s):  
Positron Emission Tomography ◽  
In Vivo Imaging ◽  
Emission Tomography ◽  
Transglutaminase Type 2 ◽  
Positron Emission

scholarly journals Role of tissue transglutaminase type 2 in calbindin–D28k interaction with ataxin-1

2007 ◽  
Vol 420 (1) ◽  
pp. 53-57 ◽  
Author(s):  
P.J.S. Vig ◽  
J. Wei ◽  
Q. Shao ◽  
M.D. Hebert ◽  
S.H. Subramony ◽  
...  
Keyword(s):  
Tissue Transglutaminase ◽  
Transglutaminase Type 2 ◽  
Calbindin D28k
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