scholarly journals The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

Cell Reports ◽  
2018 ◽  
Vol 25 (4) ◽  
pp. 841-851.e4 ◽  
Author(s):  
Sean McKay ◽  
Tomás J. Ryan ◽  
Jamie McQueen ◽  
Tim Indersmitten ◽  
Katie F.M. Marwick ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Developmental Shift ◽  
Glun2 Subunit

Developmental shift of NMDA receptor subunit component in corticospinal synapses

2011 ◽  
Vol 71 ◽  
pp. e133
Author(s):  
Mutsumi Isowaki ◽  
Takae Ohno ◽  
Noriko Iso-o ◽  
Hitoshi Maeda ◽  
Satoshi Fukuda ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit ◽  
Developmental Shift

scholarly journals NMDA Receptor Antagonists Reveal Age-Dependent Differences in the Properties of Visual Cortical Plasticity

2008 ◽  
Vol 100 (4) ◽  
pp. 1936-1948 ◽  
Author(s):  
Jacqueline de Marchena ◽  
Adam C. Roberts ◽  
Paul G. Middlebrooks ◽  
Vera Valakh ◽  
Koji Yashiro ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Cortical Plasticity ◽  
Long Term Potentiation ◽  
Underlying Mechanism ◽  
Developmental Shift ◽  
Term Potentiation ◽  
Nmdar Activation ◽  
Visual Cortical

The suggestion that NMDA receptor (NMDAR)-dependent plasticity is subunit specific, with NR2B-types required for long-term depression (LTD) and NR2A-types critical for the induction of long-term potentiation (LTP), has generated much attention and considerable debate. By investigating the suggested subunit-specific roles of NMDARs in the mouse primary visual cortex over development, we report several important findings that clarify the roles of NMDAR subtypes in synaptic plasticity. We observed that LTD was not attenuated by application of ifenprodil, an NR2B-type antagonist, or NVP-AAM007, a less selective NR2A-type antagonist. However, we were surprised that NVP-AAM007 completely blocked adult LTP (postnatal day (P) 45–90), while only modestly affecting juvenile LTP (P21-28). To assess whether this developmental transition reflected an increasing role for NR2A-type receptors with maturity, we characterized the specificity of NVP-AAM007. We found not only that NVP-AAM007 lacks discernable subunit specificity but also that the effects of NVP-AAM077 on LTP could be mimicked using subsaturating concentrations of APV, a global NMDAR antagonist. These results indicate that the effects of NVP-AAM077 on synaptic plasticity are largely explained by nonspecific blockade of NMDARs. Moreover our findings are the first to reveal a developmental increase in the sensitivity of LTP to NMDAR antagonism. We suggest that discrepant reports describing the effect of NVP-AAM077 on LTP may be partially explained by this developmental shift in the properties of LTP. These results indicate that the degree of NMDAR activation required for LTP increases with development, providing insight into a novel underlying mechanism governing the properties of synaptic plasticity.

Developmental shift of NMDA receptor subunits is essential for closing the critical period in corticospinal synapse elimination

2011 ◽  
Vol 71 ◽  
pp. e232
Author(s):  
Takae Ohno ◽  
Mutsumi Isowaki ◽  
Noriko Isoo ◽  
Naoyuki Murabe ◽  
Hitoshi Maeda ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Critical Period ◽  
Synapse Elimination ◽  
Nmda Receptor Subunits ◽  
Developmental Shift

scholarly journals Influence of GluN2 subunit identity on NMDA receptor function

2013 ◽  
Vol 74 ◽  
pp. 4-17 ◽  
Author(s):  
D.J.A. Wyllie ◽  
M.R. Livesey ◽  
G.E. Hardingham
Keyword(s):  
Nmda Receptor ◽  
Receptor Function ◽  
Nmda Receptor Function ◽  
Glun2 Subunit
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