scholarly journals Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue

Cell Reports ◽  
2018 ◽  
Vol 25 (3) ◽  
pp. 551-560.e5 ◽  
Author(s):  
Paul Petrus ◽  
Niklas Mejhert ◽  
Patricia Corrales ◽  
Simon Lecoutre ◽  
Qian Li ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Growth Factor ◽  
White Adipose Tissue ◽  
Transforming Growth Factor ◽  
Subcutaneous White Adipose Tissue

scholarly journals Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children

2019 ◽  
Vol 20 (20) ◽  
pp. 5204 ◽  
Author(s):  
Niklas Gaebler ◽  
Benedikt Haggenmüller ◽  
Melanie Kapapa ◽  
Alexandre Serra ◽  
Daniel Tews ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Growth Factor ◽  
White Adipose Tissue ◽  
Elective Surgery ◽  
Standard Deviation Score ◽  
Tissue Level ◽  
Angiogenic Factors ◽  
Adipocyte Size ◽  
Tissue Samples ◽  
Subcutaneous White Adipose Tissue

The growth of adipose tissue and its vasculature are tightly associated. Angiogenic factors have been linked to obesity, yet little is known about their expression during early childhood. To identify associations of angiogenic factors with characteristics on individual and tissue level, subcutaneous white adipose tissue samples were taken from 45 children aged 0–9 years undergoing elective surgery. We measured the expression of vascular endothelial growth factor A (VEFGA), fibroblast growth factor 1 and 2 (FGF1, FGF2), angiopoietin 1 and 2 (ANGPT1, ANGPT2), TEK receptor tyrosine kinase (TEK), and von Willebrand factor (VWF). In addition, we determined the mean adipocyte size in histologic tissue sections. We found positive correlations of age with FGF1 and FGF2 and a negative correlation with ANGPT2, with pronounced differences in the first two years of life. FGF1, FGF2, and ANGPT1 correlated positively with adipocyte size. Furthermore, we identified a correlation of ANGPT1 and TEK with body mass index-standard deviation score (BMI-SDS), a measure to define childhood obesity. Except for ANGPT2, all angiogenic factors correlated positively with the endothelial marker VWF. In sum, our findings suggest that differences related to BMI-SDS begin early in childhood, and the analyzed angiogenic factors possess distinct roles in adipose tissue biology.

Acceptance of Murine Islet Allografts without Immunosuppression in the Inguinal Subcutaneous White Adipose Tissue Pretreated with bFGF

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 32-OR
Author(s):  
YUKI NAKAFUSA ◽  
NAOYOSHI NITTA ◽  
MASAFUNI NAKAMURA ◽  
YOHICHI YASUNAMI
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Subcutaneous White Adipose Tissue ◽  
Islet Allografts

Abdominal Subcutaneous White Adipose Tissue in Surgically Slimmed Ex-Obese Shows the Same Molecular Features as Morbidly Obese Adipose Tissue

2011 ◽  
pp. OR11-4-OR11-4
Author(s):  
Raffaella Cancello ◽  
Alessandra Zulian ◽  
Davide Gentilini ◽  
Margherita Maffei ◽  
Alberto Della Barba ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Morbidly Obese ◽  
Subcutaneous White Adipose Tissue ◽  
Molecular Features

scholarly journals PO-043 The Effects of One-Time High Intensity Intermittent Training on Expression of LC3 Gene in Rats’ White Adipose Tissue

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Qishu Zhou ◽  
Chunyu Liang ◽  
Yafei Li ◽  
Yi Yan
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
High Intensity ◽  
High Fat Diet ◽  
Intermittent Exercise ◽  
Diet Group ◽  
Control Group ◽  
High Fat ◽  
Subcutaneous White Adipose Tissue ◽  
White Fat

Objective  To investigate the effect of one-time high-intensity intermittent exercise in white fat autophagy in obese rats and provide a theoretical basis of the molecular mechanism of exercise fat loss. Methods  Eighteen male 3-weeks-old rats were selected and divided into control group fed with normal diet (C), high-fat diet group fed with high fat diet (H). After 16 weeks, there were twelve obesity rats that divided into diet group (HS) and exercise group (HE). The other six control group rats of 19 weeks age were used as the standard (CS group). OE group did the high intensity intermittent exercise once. The CS group and the CS group were kept quietly. Three groups were taken subcutaneous white adipose tissue(S) and epididymal white adipose tissue (E) immediately after exercise. Mensurate the expression of LC3 gene in the tissue using the fluorescent quantitative PCR. Results 1. The expression of LC3 mRNA from white fat tissue was different to the tissues, which the expression of epididymal white adipose tissue of each group was higher than that in subcutaneous white adipose tissue (P <0.01). 2. Compared with CS group, the expression of epididymal white fat adipose tissue LC3 mRNA decreased (P<0.01) and the expression of the subcutaneous white adipose tissue increased from HS group (P <0.05). 3. Compared with OS group, the expression of epididymal white fat adipose tissue LC3 mRNA decreased (P<0.05) and the expression of subcutaneous white adipose tissue decreased from OS group. Conclusions The expression of LC3mRNA in epididymal white fat adipose tissue of rats was significantly higher than that of subcutaneous white fat. The changes of LC3mRNA expression of adipose tissue caused by high-fat diet have tissue differences. One-time high-intensity intermittent exercise can reduce the expression of LC3mRNA in fat tissue of obese rats. Its regulatory mechanism needs to be further studied.

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

2014 ◽  
Vol 399 (1-2) ◽  
pp. 95-103 ◽  
Author(s):  
Mrittika Chattopadhyay ◽  
Vineet Kumar Khemka ◽  
Gargi Chatterjee ◽  
Anirban Ganguly ◽  
Satinath Mukhopadhyay ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Oxidative Damage ◽  
White Adipose Tissue ◽  
Ros Production ◽  
Subcutaneous White Adipose Tissue
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