scholarly journals Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing

Cell Reports ◽  
2018 ◽  
Vol 25 (3) ◽  
pp. 585-597.e7 ◽  
Author(s):  
Simon Joost ◽  
Tina Jacob ◽  
Xiaoyan Sun ◽  
Karl Annusver ◽  
Gioele La Manno ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Single Cell ◽  
Hair Follicle ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39663 ◽  
Author(s):  
Juan Li ◽  
Hai Zheng ◽  
Junfeng Wang ◽  
Fang Yu ◽  
Rebecca J. Morris ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Hair Follicle ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals High‐resolution single‐cell transcriptomics reveals heterogeneity of self‐renewing hair follicle stem cells

2021 ◽  
Author(s):  
Gopal Chovatiya ◽  
Sangeeta Ghuwalewala ◽  
Lauren D. Walter ◽  
Benjamin D. Cosgrove ◽  
Tudorita Tumbar
Keyword(s):  
Stem Cells ◽  
High Resolution ◽  
Single Cell ◽  
Hair Follicle ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells ◽  
Resolution Single

Are hair follicle stem cells promising candidates for wound healing?

2019 ◽  
Vol 19 (2) ◽  
pp. 119-128 ◽  
Author(s):  
Bingmin Li ◽  
Wenzhi Hu ◽  
Kui Ma ◽  
Cuiping Zhang ◽  
Xiaobing Fu
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Hair Follicle ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Extracellular caspase-1 regulates hair follicle stem cell migration during wound-healing

2019 ◽  
Author(s):  
Subhasri Ghosh ◽  
Akhil SHP Ananthan ◽  
Sunny Kataria ◽  
Neha Pincha ◽  
Abhik Dutta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Stem Cell ◽  
Hair Follicle ◽  
Healing Process ◽  
Environmental Cues ◽  
Macromolecular Complex ◽  
Caspase 1 ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

AbstractMigration of stem cells from one niche to another is a fundamental behavior observed during tissue morphogenesis, homeostasis, and repair 1. A common thread running throughout these phenomena is the ability of stem cells to sense their environmental cues that, in turn, regulate their spatiotemporal localization with amazing precision. Perturbations of such cellular responses underlie a spectrum of pathologies ranging from developmental defects, tumor metastasis and ineffective wound closure 2,3. In somatic tissues, the wound-healing process is a paradigm of the directed migration of various stem cell pools to the site of injury where they differentiate to replenish lost or damaged cells. While there has been substantial investment and progress in understanding the lineage trajectory of stem cells once they reach their destination, comparatively little is understood regarding the mechanisms guiding their chemotactic journey to the wound site. In the context of the skin, it has been shown nearly two decades ago that wounding activates various local epithelial stem cell pools, including multipotent hair follicle stem cells, to infiltrate the epidermis where they participate in the reconstruction of the damaged tissue 4,5. However, elucidation of the environmental cues that coax these cells out of their hair follicle niche to the damaged epidermis has proven to be an intractable problem to solve. Using both an excisional wound and genetic mouse models of wound healing, we discovered that wounded keratinocytes secrete the enzyme Caspase-1. This protein is classically known as a critical component of the cytosolic macromolecular complex called an inflammasome that mediates the unconventional secretion of various cytokines including IL-1a 6. Surprisingly, we find that the released caspase-1 itself has a non-canonical role in the extracellular milieu. Through the Caspase Activation Recruitment Domain (CARD) of caspase-1, this protein is sufficient to initiate chemotaxis of hair follicle stem cells into the epidermis. The secretion of caspase-1 has also been documented in many other pathological scenarios7,8 and we observed that the migration of HFSCs into the epidermis following UV irradiation of the skin is also caspase-1 dependent. Uncovering this novel function of Caspase-1 facilitates a deeper understanding of the mechanistic basis of the epithelial hyperplasia found to accompany numerous inflammatory skin diseases.

scholarly journals Effects of Hair Follicle Stem Cells on Partial-Thickness Burn Wound Healing and Tensile Strength

2020 ◽  
Vol 24 (2) ◽  
pp. 99-109 ◽  
Author(s):  
Azar Babakhani ◽  
Malihe Nobakht ◽  
Hamidreza Pazoki Torodi ◽  
Mostafa Dahmardehei ◽  
Paria Hashemi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Tensile Strength ◽  
Hair Follicle ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Partial Thickness ◽  
Partial Thickness Burn ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells
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