scholarly journals The Locus Coeruleus Modulates Intravenous General Anesthesia of Zebrafish via a Cooperative Mechanism

Cell Reports ◽  
2018 ◽  
Vol 24 (12) ◽  
pp. 3146-3155.e3 ◽  
Author(s):  
Wen-jie Du ◽  
Rong-wei Zhang ◽  
Jia Li ◽  
Bai-bing Zhang ◽  
Xiao-lan Peng ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Locus Coeruleus ◽  
Intravenous General Anesthesia

scholarly journals Incidence of Postoperative Cognitive Dysfunction Following Inhalational Vs. Total Intravenous General Anesthesia: A Systematic Review and Meta-Analysis.

2022 ◽  
Author(s):  
Daniel Negrini ◽  
Andrew Wu ◽  
Atsushi Oba ◽  
Ben Harnke ◽  
Nicholas Ciancio ◽  
...  
Keyword(s):  
Systematic Review ◽  
General Anesthesia ◽  
Cognitive Dysfunction ◽  
Meta Analysis ◽  
Postoperative Cognitive Dysfunction ◽  
Primary Objective ◽  
Intravenous Anesthesia ◽  
Robust Designs ◽  
Secondary Objective ◽  
Intravenous General Anesthesia

Abstract Postoperative cognitive dysfunction (POCD) has been increasingly recognized as a contributor to postoperative complications. A consensus-working group recommended that POCD should be distinguished between delayed cognitive recovery, i.e., evaluations up to 30 days postoperative, and neurocognitive disorder, i.e., assessments performed between 30 days and 12 months after surgery. Additionally, the choice of the anesthetic, either inhalational or total intravenous anesthesia (TIVA) and its effect on the incidence of POCD, has become a focus of research. Our primary objective was to search the literature and conduct a meta-analysis to verify whether the choice of general anesthesia may impact the incidence of POCD in the first 30 days postoperatively. As a secondary objective, a systematic review of the literature was conducted to estimate the effects of the anesthetic on POCD between 30 days and 12 months postoperative. For the primary objective, an initial review of 1,913 articles yielded 12 studies with a total of 3,639 individuals. For the secondary objective, five studies with a total of 751 patients were selected. In the first 30 days postoperative, the odds-ratio for POCD in TIVA group was 0.60 (95% CI = 0.40 - 0.91; p = 0.02), compared to the inhalational group. TIVA was associated with a lower incidence of POCD in the first 30 days postoperatively. Regarding the secondary objective, due to the small number of selected articles and its high heterogeneity, a metanalysis was not conducted. Giving the heterogeneity of criteria for POCD, future prospective studies with more robust designs should be performed to fully address this question.

scholarly journals Quality of recovery from anesthesia of patients undergoing balanced or total intravenous general anesthesia. Prospective randomized clinical trial

2016 ◽  
Vol 35 ◽  
pp. 369-375 ◽  
Author(s):  
Eduardo Toshiyuki Moro ◽  
Fábio Caetano Oliveira Leme ◽  
Bernardo Roveda Noronha ◽  
Gustavo Farinha Pinto Saraiva ◽  
Nathália Vianna de Matos Leite ◽  
...  
Keyword(s):  
Clinical Trial ◽  
General Anesthesia ◽  
Randomized Clinical Trial ◽  
Prospective Randomized Clinical Trial ◽  
Quality Of Recovery ◽  
Recovery From Anesthesia ◽  
Intravenous General Anesthesia

Intravenous General Anesthesia Is Not  Intravenous Sedation

1990 ◽  
Vol 73 (5) ◽  
pp. 1055-1056 ◽  
Author(s):  
Alan S. Klein ◽  
Eric Kunichika ◽  
Joseph R. Furman ◽  
Melvin D. Smith
Keyword(s):  
General Anesthesia ◽  
Intravenous Sedation ◽  
Intravenous General Anesthesia
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