scholarly journals Phosphatidylserine Externalization Results from and Causes Neurite Degeneration in Drosophila

Cell Reports ◽  
2018 ◽  
Vol 24 (9) ◽  
pp. 2273-2286 ◽  
Author(s):  
Maria L. Sapar ◽  
Hui Ji ◽  
Bei Wang ◽  
Amy R. Poe ◽  
Kush Dubey ◽  
...  
Keyword(s):  
Phosphatidylserine Externalization ◽  
Neurite Degeneration

Long Noncoding RNA SPRY4-IT1 Modulates Ketamine-Induced Neurotoxicity in Human Embryonic Stem Cell-Derived Neurons through EZH2

2021 ◽  
pp. 1-9
Author(s):  
Jingyuan Huang ◽  
Yan Xu ◽  
Fang Wang ◽  
Haili Wang ◽  
Lu Li ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Embryonic Stem ◽  
Protective Effects ◽  
Tyrosine Kinase Signaling ◽  
Ezh2 Expression ◽  
Induced Neurons ◽  
Neurite Degeneration ◽  
Dose Dependent

<b><i>Objective:</i></b> This study aimed to investigate whether long noncoding RNA sprouty receptor tyrosine kinase signaling antagonist 4-intronic transcript 1 (SPRY4-IT1) is involved in the regulation of ketamine-induced neurotoxicity. <b><i>Methods:</i></b> Human embryonic stem cells (hESCs) were induced into neurons in vitro and treated with ketamine. Apoptosis and neurite degeneration assays were used to determine ketamine-induced neurotoxicity and qRT-PCR to determine SPRY4-IT1 expression. SPRY4-IT1 was downregulated in hESC-induced neurons to examine its regulation on ketamine-induced neurotoxicity. The correlation between enhancer of zeste homolog 2 (EZH2) and SPRY4-IT1 was also examined. EZH2 was upregulated in SPRY4-IT1-downregualted hESC-induced neurons to further examine its participation in SPRY4-IT1-mediated ketamine neurotoxicity. <b><i>Results:</i></b> Ketamine-induced dose-dependent apoptosis, neurite degeneration, and SPRY4-IT1 upregulation in hESC-induced neurons. Lentivirus-mediated SPRY4-IT1 downregulation protected ketamine neurotoxicity. EZH2 expression was positively correlated with SPRY4-IT1 in hESC-induced neurons. EZH2 overexpression markedly reversed the protective effects of SPRY4-IT1 knockdown on ketamine neurotoxicity. <b><i>Conclusions:</i></b> SPRY4-IT1 is involved in anesthesia-induced neurotoxicity, possibly through the regulation on EZH2 gene.

scholarly journals Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

PLoS Biology ◽  
2017 ◽  
Vol 15 (6) ◽  
pp. e2002711 ◽  
Author(s):  
Sefi Zargarian ◽  
Inbar Shlomovitz ◽  
Ziv Erlich ◽  
Aria Hourizadeh ◽  
Yifat Ofir-Birin ◽  
...  
Keyword(s):  
Phosphatidylserine Externalization

C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1

2007 ◽  
Vol 9 (5) ◽  
pp. 541-549 ◽  
Author(s):  
Xiaochen Wang ◽  
Jin Wang ◽  
Keiko Gengyo-Ando ◽  
Lichuan Gu ◽  
Chun-Ling Sun ◽  
...  
Keyword(s):  
Apoptotic Cells ◽  
C Elegans ◽  
Phospholipid Scramblase ◽  
Phosphatidylserine Externalization

scholarly journals CALCIUM INFLUX ACCELERATES NEURITE DEGENERATION VIA MITOCHONDRIAL-DEPENDENT OXIDATION

2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 1153-1153
Author(s):  
K. Fukui ◽  
S. Nakamura ◽  
A. Nakanishi ◽  
S. Okihiro ◽  
H. Takatsu
Keyword(s):  
Calcium Influx ◽  
Neurite Degeneration

scholarly journals Stabilin Receptors: Role as Phosphatidylserine Receptors

Biomolecules ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 387 ◽  
Author(s):  
Seung-Yoon Park ◽  
In-San Kim
Keyword(s):  
Plasma Membrane ◽  
Cell Fusion ◽  
Apoptotic Cell ◽  
Lymphocyte Activation ◽  
Membrane Receptors ◽  
Phosphatidylserine Externalization ◽  
Outer Leaflet ◽  
Physiological Processes ◽  
Apoptotic Cell Clearance ◽  
Cell Clearance

Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal fusion. Stabilin-1 and stabilin-2 are membrane receptors that recognize phosphatidylserine on the cell surface. Here, we discuss the functions of Stabilin-1 and stabilin-2 as phosphatidylserine receptors in apoptotic cell clearance (efferocytosis) and cell fusion, and their ligand-recognition and signaling pathways.

scholarly journals A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model

2013 ◽  
Vol 34 (8) ◽  
pp. 2052-2063 ◽  
Author(s):  
Juliet K. Knowles ◽  
Danielle A. Simmons ◽  
Thuy-Vi V. Nguyen ◽  
Lilith Vander Griend ◽  
Youmei Xie ◽  
...  
Keyword(s):  
Mouse Model ◽  
Small Molecule ◽  
Cognitive Deficits ◽  
Neurite Degeneration

Nanopore Formation and Phosphatidylserine Externalization in a Phospholipid Bilayer at High Transmembrane Potential

2006 ◽  
Vol 128 (19) ◽  
pp. 6288-6289 ◽  
Author(s):  
P. Thomas Vernier ◽  
Matthew J. Ziegler ◽  
Yinghua Sun ◽  
Wenji V. Chang ◽  
Martin A. Gundersen ◽  
...  
Keyword(s):  
Transmembrane Potential ◽  
Phospholipid Bilayer ◽  
Phosphatidylserine Externalization
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