scholarly journals FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells

Cell Reports ◽  
2018 ◽  
Vol 24 (5) ◽  
pp. 1176-1189 ◽  
Author(s):  
Allison B. Herman ◽  
Christine N. Vrakas ◽  
Mitali Ray ◽  
Sheri E. Kelemen ◽  
Michael J. Sweredoski ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Muscle Cells

scholarly journals Enhanced Proliferation of Cultured Human Vascular Smooth Muscle Cells Linked to Increased Function of RNA-binding Protein HuR

2005 ◽  
Vol 280 (24) ◽  
pp. 22819-22826 ◽  
Author(s):  
Rudolf Pullmann ◽  
Magdalena Juhaszova ◽  
Isabel López de Silanes ◽  
Tomoko Kawai ◽  
Krystyna Mazan-Mamczarz ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Muscle Cells

Translational regulation of ANG II type 1 receptors in proliferating vascular smooth muscle cells

2006 ◽  
Vol 290 (1) ◽  
pp. R50-R56 ◽  
Author(s):  
Sunghou Lee ◽  
Hong Ji ◽  
Zheng Wu ◽  
Wei Zheng ◽  
Ali Hassan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Muscle Cells ◽  
Distribution Analysis ◽  
Exon 2

The current study examined angiotensin receptor (ATR) regulation in proliferating rat aortic vascular smooth muscle cells (VSMCs) in culture. Radioligand competition analysis coupled with RNase protection assays (RPAs) revealed that angiotensin type 1a receptor (AT1aR) densities (Bmax) increased by 30% between 5 and 7 days in culture [Bmax (fmol/mg protein): day 5, 379 ± 8.4 vs. day 7, 481 ± 12, n = 3, P < 0.05] under conditions in which no significant changes in AT1aR mRNA expression occurred [in RPA arbitrary units (AU): day 5, 0.23 ± 0.01 vs. day 7, 0.24 ± 0.04, n = 4] or in mRNA synthesis determined by nuclear run-on assays [AU: day 5, 0.35 ± 0.14 vs. day 7, 0.33 ± 0.11, n = 5]. In contrast, polysome distribution analysis indicated that AT1aR mRNA was more efficiently translated in day 7 cells compared with day 5 [% of AT1aR mRNA in fraction 2 out of total AT1R mRNA recovered from the sucrose gradient: day 5, 20.9 ± 9.9 vs. day 7, 56.8 ± 5.6, n = 3, P < 0.001]. Accompanying the polysome shift was 50% less RNA-protein complex (RPC) formation between VSMC cytosolic RNA binding proteins in day 7 cells compared with 5-day cultures and the 5′ leader sequence (5′LS) of the AT1aR [5′LS RPC (AU): day 5, 0.62 ± 0.15 vs. day 7, 0.23 ± 0.03; n = 4, P < 0.05] and also with exon 2 [Exon 2 RPC (AU): day 5, 35.0 ± 5.7 vs. day 7, 17.2 ± 3.6; n = 4, P < 0.05]. Taken together, these results suggest that AT1aR expression is regulated by translation during VSMC proliferation in part by RNA binding proteins that interact within exon 2 in the 5′LS of the AT1aR mRNA.

scholarly journals Apoptosis Induced by Inhibition of Cyclic AMP Response Element–Binding Protein in Vascular Smooth Muscle Cells

Circulation ◽  
2003 ◽  
Vol 108 (10) ◽  
pp. 1246-1252 ◽  
Author(s):  
Tomotake Tokunou ◽  
Rei Shibata ◽  
Hisashi Kai ◽  
Toshihiro Ichiki ◽  
Takashi Morisaki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Binding Protein ◽  
Muscle Cells ◽  
Response Element ◽  
Element Binding Protein ◽  
Cyclic Amp Response Element

Small GTP binding protein Ras contributes to norepinephrine-induced mitogenesis of vascular smooth muscle cells

2001 ◽  
Vol 65 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Mubarack M. Muthalif ◽  
Mohammed R. Uddin ◽  
Soghra Fatima ◽  
Jean-Hugues Parmentier ◽  
Zinat Khandekar ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Binding Protein ◽  
Muscle Cells ◽  
Gtp Binding Protein ◽  
Gtp Binding
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