scholarly journals The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function

Cell Reports ◽  
2017 ◽  
Vol 21 (3) ◽  
pp. 692-706 ◽  
Author(s):  
Onkar B. Sawant ◽  
Amanda M. Horton ◽  
Olivia F. Zucaro ◽  
Ricky Chan ◽  
Vera L. Bonilha ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Circadian Clock ◽  
Clock Gene ◽  
Cone Photoreceptor ◽  
Circadian Clock Gene ◽  
Spectral Identity

scholarly journals Removal of clock gene Bmal1 from the retina affects retinal development and accelerates cone photoreceptor degeneration during aging

2018 ◽  
Vol 115 (51) ◽  
pp. 13099-13104 ◽  
Author(s):  
Kenkichi Baba ◽  
Ilaria Piano ◽  
Polina Lyuboslavsky ◽  
Micah A. Chrenek ◽  
Jana T. Sellers ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Visual Function ◽  
Visual Information ◽  
Clock Gene ◽  
Cone Photoreceptor ◽  
Circadian Clock Gene ◽  
Affect Cell Viability ◽  
Retinal Structure ◽  
Development And Aging ◽  
Plexiform Layers

The mammalian retina contains an autonomous circadian clock system that controls many physiological functions within this tissue. Previous studies on young mice have reported that removal of the key circadian clock gene Bmal1 from the retina affects the circadian regulation of visual function, but does not affect photoreceptor viability. Because dysfunction in the circadian system is known to affect cell viability during aging in other systems, we compared the effect of Bmal1 removal from the retina on visual function, inner retinal structure, and photoreceptor viability in young (1 to 3 months) and aged (24 to 26 months) mice. We found that removal of Bmal1 from the retina significantly affects visual information processing in both rod and cone pathways, reduces the thickness of inner retinal nuclear and plexiform layers, accelerates the decline of visual functions during aging, and reduces the viability of cone photoreceptors. Our results thus suggest that circadian clock dysfunction, caused by genetic or other means, may contribute to the decline of visual function during development and aging.

The Thyroid Hormone Receptor Alpha Locus and Brain: A Role for the Circadian Clock Gene Rev-Erbα.

2010 ◽  
pp. P2-591-P2-591
Author(s):  
M Medici ◽  
MA Ikram ◽  
M Verbiest ◽  
AG Uitterlinden ◽  
MM Breteler ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Circadian Clock ◽  
Hormone Receptor ◽  
Clock Gene ◽  
Thyroid Hormone Receptor ◽  
Circadian Clock Gene ◽  
Receptor Alpha

scholarly journals Effect of Circadian Clock Gene Mutations on Nonvisual Photoreception in the Mouse

2012 ◽  
Vol 53 (1) ◽  
pp. 454 ◽  
Author(s):  
Leah Owens ◽  
Ethan Buhr ◽  
Daniel C. Tu ◽  
Tamara L. Lamprecht ◽  
Janet Lee ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Clock Gene ◽  
Gene Mutations ◽  
Circadian Clock Gene
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