scholarly journals Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury

Cell Reports ◽  
2017 ◽  
Vol 20 (5) ◽  
pp. 1136-1147 ◽  
Author(s):  
Véronique Lisi ◽  
Bhagat Singh ◽  
Michel Giroux ◽  
Elmer Guzman ◽  
Michio W. Painter ◽  
...  
Keyword(s):  
Mouse Strain ◽  
Neuronal Regeneration ◽  
Differentiation Markers

scholarly journals Enhanced neuronal regeneration in the CAST/Ei mouse strain is linked to expression of differentiation markers after injury

2017 ◽  
Author(s):  
Véronique Lisi ◽  
Bhagat Singh ◽  
Michel Giroux ◽  
Elmer Guzman ◽  
Michio W Painter ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Mouse Strain ◽  
Peripheral Nerve Regeneration ◽  
Neuronal Regeneration ◽  
Drg Neurons ◽  
Differentiation Markers ◽  
Neuronal Identity ◽  
Transcriptional Changes ◽  
Neuronal Profile ◽  
Broad Program

SummaryPeripheral nerve regeneration after injury requires a broad program of transcriptional changes. We investigated the basis for the enhanced nerve regenerative capacity of the CAST/Ei mouse strain relative to C57BL/6 mice. RNA sequencing of dorsal root ganglia (DRG) showed a CAST/Ei specific upregulation of Ascl1 after injury. Ascl1 overexpression in C57BL/6 mice DRG neurons enhanced their neurite outgrowth. Ascl1 is regulated by miR-7048-3p, which is down-regulated in CAST/Ei mice. Inhibition of miR-7048-3p enhances neurite outgrowth. Following injury, CAST/Ei neurons largely retained their mature neuronal profile as determined by single cell RNAseq, whereas the C57BL/6 neurons acquired an immature profile. These findings suggest that one facet of the enhanced regenerative phenotype is preservation of neuronal identity in response to injury.

Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses.

1976 ◽  
Vol 20 (2) ◽  
pp. 436-440 ◽  
Author(s):  
K Kai ◽  
H Ikeda ◽  
Y Yuasa ◽  
S Suzuki ◽  
T Odaka
Keyword(s):  
Mouse Strain ◽  
Leukemia Viruses ◽  
Murine Leukemia

scholarly journals Biosynthesis and intra-axonal transport of proteins during neuronal regeneration.

1980 ◽  
Vol 255 (13) ◽  
pp. 6494-6501
Author(s):  
D. Giulian ◽  
H. Des Ruisseux ◽  
D. Cowburn
Keyword(s):  
Axonal Transport ◽  
Neuronal Regeneration
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