scholarly journals The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation

Cell Reports ◽  
2017 ◽  
Vol 18 (12) ◽  
pp. 2979-2990 ◽  
Author(s):  
Daniel Benhalevy ◽  
Sanjay K. Gupta ◽  
Charles H. Danan ◽  
Suman Ghosal ◽  
Hong-Wei Sun ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Zinc Finger ◽  
Binding Protein ◽  
Nucleic Acid Binding ◽  
Nucleic Acid Binding Protein ◽  
Coding Sequences ◽  
Target Mrna ◽  
Acid Binding Protein

cDNA cloning and developmental expression of cellular nucleic acid-binding protein (CNBP) gene in Xenopus laevis

Gene ◽  
2000 ◽  
Vol 241 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Alessandra De Dominicis ◽  
Francesco Lotti ◽  
Paola Pierandrei-Amaldi ◽  
Beatrice Cardinali
Keyword(s):  
Nucleic Acid ◽  
Xenopus Laevis ◽  
Cdna Cloning ◽  
Binding Protein ◽  
Developmental Expression ◽  
Nucleic Acid Binding ◽  
Nucleic Acid Binding Protein ◽  
Acid Binding Protein

scholarly journals brlA requires both zinc fingers to induce development.

1990 ◽  
Vol 10 (4) ◽  
pp. 1815-1817 ◽  
Author(s):  
T H Adams ◽  
H Deising ◽  
W E Timberlake
Keyword(s):  
Nucleic Acid ◽  
Aspergillus Nidulans ◽  
Binding Protein ◽  
Zinc Fingers ◽  
Nucleic Acid Binding ◽  
Developmental Pathway ◽  
Nucleic Acid Binding Protein ◽  
Acid Binding Protein ◽  
Coordination Sites ◽  
Brla Gene

Expression of the Aspergillus nidulans brlA gene induces a developmental pathway leading to the production of asexual spores. We have introduced mutations into brlA that are expected to disrupt either or both Cys2-His2 Zn(II) coordination sites postulated to exist in the BrlA polypeptide. The resultant brlA alleles fail to induce either the asexual reproductive pathway or the expression of development-specific genes. These data support the hypothesis that brlA encodes a nucleic acid-binding protein whose activity requires each of two zinc fingers.

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