scholarly journals Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer

Cell Reports ◽  
2016 ◽  
Vol 17 (10) ◽  
pp. 2620-2631 ◽  
Author(s):  
Ram S. Mani ◽  
Mohammad A. Amin ◽  
Xiangyi Li ◽  
Shanker Kalyana-Sundaram ◽  
Brendan A. Veeneman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Gene Fusion

Combination Therapies Using Metformin and/or Valproic Acid in Prostate Cancer: Possible Mechanistic Interactions

2019 ◽  
Vol 19 (5) ◽  
pp. 368-381 ◽  
Author(s):  
Linh N.K. Tran ◽  
Ganessan Kichenadasse ◽  
Pamela J. Sykes
Keyword(s):  
Prostate Cancer ◽  
Valproic Acid ◽  
Androgen Receptor ◽  
Gene Fusion ◽  
Combination Therapies ◽  
Slowing Down ◽  
Castration Resistant ◽  
Local Pca ◽  
End Stage ◽  
Fusion Products

Prostate cancer (PCa) is the most frequent cancer in men. The evolution from local PCa to castration-resistant PCa, an end-stage of disease, is often associated with changes in genes such as p53, androgen receptor, PTEN, and ETS gene fusion products. Evidence is accumulating that repurposing of metformin (MET) and valproic acid (VPA) either when used alone, or in combination, with another therapy, could potentially play a role in slowing down PCa progression. This review provides an overview of the application of MET and VPA, both alone and in combination with other drugs for PCa treatment, correlates the responses to these drugs with common molecular changes in PCa, and then describes the potential for combined MET and VPA as a systemic therapy for prostate cancer, based on potential interacting mechanisms.

Emerging Biomarkers and Contributing Factors of Prostate Cancer.

2020 ◽  
Vol 16 ◽  
Author(s):  
Mini Dahiya ◽  
Monu Yadav ◽  
Kalpana Nagpal ◽  
Nidhi Sharma ◽  
Kajal Joshi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Tumor Suppressor Genes ◽  
Therapeutic Strategy ◽  
Cannabinoid Receptors ◽  
Contributing Factors ◽  
Cause Of Deaths ◽  
Pharmaceutical Industries ◽  
Brca1 Brca2 ◽  
Molecular Pathophysiology

: Prostate Cancer (PC) is one the most prominent cause of deaths in males worldwide especially in western countries. The exhaustive research into prostate cancer to date has demonstrated ELAC2, RNASEL, MSR1, NBS1, CHEK2, MYC, BCL-2, c-Kit, tumor suppressor genes, BRCA1, BRCA2, PACE4, GSTP1, PTEN,CDKN1B, NKX3.1, KLF6, FOXA1, Retinoblastoma, p53, androgen receptor, kallikreins, ETS, CYP17, SRD5A2, E-cadherin, KAI1/CD82, hepsin, AMACR, PIM1, MTA-1, EZH2, EPHB2, growth factors & its receptors, cannabinoid receptors, annexins, oxidative stress and inflammation are entailed changes underlying the initiation, development, and progression of PC. Furthermore, oncology would shift from a reactive to proactive discipline so exploring these targets open new area of research. Therefore, the present review is focused on molecular pathophysiology biomarkers for the progression of PC that would encourage the researchers and pharmaceutical industries to investigate potential therapeutic strategy to overcome demerits of currently available clinically therapies.

784 TMPRSS2-ERG GENE FUSION DEFINES A METASTATIC PHENOTYPE OF PROSTATE CANCER

2009 ◽  
Vol 8 (4) ◽  
pp. 316
Author(s):  
S. Perner ◽  
M. Svensson ◽  
R. Hossain ◽  
J. Day ◽  
J. Groskopf ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Fusion ◽  
Metastatic Phenotype

scholarly journals Oxidative Stress and Antiandrogen Resistance in Prostate Cancer

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Michelle Anne Schultz ◽  
Asim B. Abdel Mageed ◽  
Krishna Agrawal ◽  
Debasis Mondal
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer

scholarly journals Associations Between Polymorphisms in Genes Related to Oxidative Stress and DNA Repair, Interactions With Serum Antioxidants, and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial

2022 ◽  
Vol 11 ◽  
Author(s):  
Zhihong Gong ◽  
Mary E. Platek ◽  
Cathee Till ◽  
Phyllis J. Goodman ◽  
Catherine M. Tangen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Prevention ◽  
Prostate Cancer Risk ◽  
Minor Allele ◽  
Cancer Etiology ◽  
Lower Serum ◽  
Prostate Cancer Prevention

Study of polymorphisms in genes related to the generation and removal of oxidative stress and repair of oxidative DNA damage will lead to new insights into the genetic basis of prostate cancer. In the Prostate Cancer Prevention Trial (PCPT), a double-blind, randomized controlled trial testing finasteride versus placebo for prostate cancer prevention, we intend to investigate the role of oxidative stress/DNA repair mechanisms in prostate cancer etiology and whether these polymorphisms modify prostate cancer risk by interacting with antioxidant status in both placebo and finasteride arms. We evaluated associations of selected candidate polymorphisms in genes in these pathways, and interactions with pre-diagnostic serum antioxidants, and the risk of prostate cancer among 1,598 cases and 1,706 frequency-matched controls enrolled in the PCPT. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable-adjusted logistic regression models. While there were no statistically significant associations observed in the placebo arm, several SNPs were associated with prostate cancer in the finasteride arm. Specifically, APEX1-rs1760944 was associated with increased risk of total prostate cancer (per minor allele: p-trend=0.04). OGG1-rs1052133 was positively (CG/GG vs. CC: OR=1.32, 95% CI: 1.01-1.73) and NOS3-rs1799983 was inversely (per minor allele: p-trend=0.04) associated with risk of low-grade prostate cancer. LIG3-rs1052536 and XRCC1-rs25489 were suggestively associated with reduced risk of high-grade prostate cancer (per minor allele: both p-trend=0.04). In the placebo arm, significant associations were observed among men with higher serum lycopene for APEX1-rs1760944 and NQO1-rs1800566, or higher serum β-cryptoxanthin for ERCC4-rs1800067. In the finasteride arm, stronger associations were observed among men with lower serum lycopene for NOS3-rs1799983, higher serum α-carotene, β-carotene, and β-cryptoxanthin for LIG3-rs1052536, or lower serum retinol for SOD2-rs1799725. These results suggest that germline variations in oxidative stress and DNA repair pathways may contribute to prostate carcinogenesis and that these associations may differ by intraprostatic sex steroid hormone status and be further modified by antioxidant status. Findings provide insights into the complex role of gene, gene-antioxidant and -finasteride interactions in prostate cancer etiology, and thus may lead to the development of preventative strategies.

OXIDATIVE STRESS IS INHERENT IN PROSTATE CANCER CELLS AND MEDIATES AGGRESSIVE PHENOTYPE

2008 ◽  
Vol 179 (4S) ◽  
pp. 192-193 ◽  
Author(s):  
Binod Kumar ◽  
Sweaty Koul ◽  
Lakshmipathi Khandrika ◽  
Randall B Meacham ◽  
Hari K Koul
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Aggressive Phenotype

scholarly journals Androgen Receptor Requires JunD as a Coactivator to Switch on an Oxidative Stress Generation Pathway in Prostate Cancer Cells

2010 ◽  
Vol 70 (11) ◽  
pp. 4560-4568 ◽  
Author(s):  
Farideh Mehraein-Ghomi ◽  
Hirak S. Basu ◽  
Dawn R. Church ◽  
F. Michael Hoffmann ◽  
George Wilding
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Stress Generation ◽  
Prostate Cancer Cells

scholarly journals Significance of the TMPRSS2:ERG gene fusion in prostate cancer

2017 ◽  
Vol 16 (4) ◽  
pp. 5450-5458 ◽  
Author(s):  
Zhu Wang ◽  
Yuliang Wang ◽  
Jianwen Zhang ◽  
Qiyi Hu ◽  
Fan Zhi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Fusion

scholarly journals Oxidative Stress and Prostate Cancer Progression Are Elicited by Membrane-Type 1 Matrix Metalloproteinase

2011 ◽  
Vol 9 (10) ◽  
pp. 1305-1318 ◽  
Author(s):  
Hoang-Lan Nguyen ◽  
Stanley Zucker ◽  
Kevin Zarrabi ◽  
Pournima Kadam ◽  
Cathleen Schmidt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Membrane Type
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