scholarly journals STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia

Cell Reports ◽  
2016 ◽  
Vol 15 (11) ◽  
pp. 2357-2366 ◽  
Author(s):  
Emily Curran ◽  
Xiufen Chen ◽  
Leticia Corrales ◽  
Douglas E. Kline ◽  
Thomas W. Dubensky ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Pathway Activation ◽  
Sting Pathway ◽  
Acute Myeloid

Age-Specific Differences in Oncogenic Pathway Dysregulation in Patients With Acute Myeloid Leukemia

2009 ◽  
Vol 27 (33) ◽  
pp. 5580-5586 ◽  
Author(s):  
Arati V. Rao ◽  
Peter J.M. Valk ◽  
Klaus H. Metzeler ◽  
Chaitanya R. Acharya ◽  
Sascha A. Tuchman ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Elderly Patients ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Treatment Strategies ◽  
Gene Set Enrichment Analysis ◽  
Oncogenic Signaling ◽  
Younger Patients ◽  
Pathway Activation ◽  
Acute Myeloid

Purpose To define the biology driving the aggressive nature of acute myeloid leukemia (AML) in elderly patients. Patients and Methods Clinically annotated microarray data from 425 patients with newly diagnosed de novo AML from two publicly available data sets were analyzed after age-specific cohorts (young ≤ 45 years, n = 175; elderly ≥ 55 years; n = 144) were prospectively identified. Gene expression analysis was conducted utilizing gene set enrichment analysis, and by applying previously defined and tested signature profiles reflecting dysregulation of oncogenic signaling pathways and altered tumor environment. Results Elderly AML patients as expected had worse overall survival and event-free survival compared with younger patients. Analysis of oncogenic pathways revealed that older patients had higher probability of RAS, Src, and tumor necrosis factor (TNF) pathway activation (all P < .0001). Hierarchical clustering revealed that younger patients with AML in cluster 2 had clinically worse survival, with high RAS, Src, and TNF pathway activation compared with patients in cluster 1. However, among elderly patients with AML, those in cluster 1 also demonstrated high RAS, Src, and TNF pathway activation but this did not translate into differences in survival. Conclusion AML in the elderly represents a distinct biologic entity characterized by unique patterns of deregulated signaling pathway variations that contributes to poor survival. These insights should enable development and adjustments of clinically meaningful treatment strategies in the older patient population.

Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia

2019 ◽  
Vol 9 (8) ◽  
pp. 1050-1063 ◽  
Author(s):  
Christine M. McMahon ◽  
Timothy Ferng ◽  
Jonathan Canaani ◽  
Eunice S. Wang ◽  
Jennifer J.D. Morrissette ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Clonal Selection ◽  
Ras Pathway ◽  
Pathway Activation ◽  
Clinical Resistance ◽  
Acute Myeloid

scholarly journals Molecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells

Aging ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 2936-2947 ◽  
Author(s):  
Ivan Petrov ◽  
Maria Suntsova ◽  
Olga Mutorova ◽  
Maxim Sorokin ◽  
Andrew Garazha ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Pediatric Acute Myeloid Leukemia ◽  
Molecular Pathway ◽  
Pathway Activation ◽  
Acute Lymphoblast Leukemia ◽  
Acute Myeloid
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