scholarly journals Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation

Cell Reports ◽  
2016 ◽  
Vol 14 (12) ◽  
pp. 2859-2871 ◽  
Author(s):  
Harikesh S. Wong ◽  
Valentin Jaumouillé ◽  
Spencer A. Freeman ◽  
Sasha A. Doodnauth ◽  
Daniel Schlam ◽  
...  
Keyword(s):  
Foam Cell ◽  
Cell Formation ◽  
Low Density Lipoproteins ◽  
Foam Cell Formation ◽  
Low Density ◽  
Oxidized Low Density Lipoproteins ◽  
Chemokine Signaling

Fisetin prevents oxidized low-density lipoproteins induced macrophage foam cell formation

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Johnna Francis Varghese ◽  
Rohit Patel ◽  
Mohit Singh ◽  
Umesh Chand Singh Yadav
Keyword(s):  
Foam Cell ◽  
Cell Formation ◽  
Low Density Lipoproteins ◽  
Foam Cell Formation ◽  
Low Density ◽  
Macrophage Foam Cell ◽  
Oxidized Low Density Lipoproteins

β-Migrating very low density lipoproteins induce foam cell formation in mouse mesangial cells

1995 ◽  
Vol 114 (1) ◽  
pp. 123-132 ◽  
Author(s):  
Takeshi Nishikawa ◽  
Shozo Kobori ◽  
Haruo Takeda ◽  
Takayuki Higashi ◽  
Yoshihiro Sato ◽  
...  
Keyword(s):  
Mesangial Cells ◽  
Foam Cell ◽  
Cell Formation ◽  
Low Density Lipoproteins ◽  
Foam Cell Formation ◽  
Low Density ◽  
Very Low Density Lipoproteins

scholarly journals Protective Effect of Lusianthridin on Hemin-Induced Low-Density Lipoprotein Oxidation

2021 ◽  
Vol 14 (6) ◽  
pp. 567
Author(s):  
Su Wutyi Thant ◽  
Noppawan Phumala Morales ◽  
Visarut Buranasudja ◽  
Boonchoo Sritularak ◽  
Rataya Luechapudiporn
Keyword(s):  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Raw 264.7 ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Raw 264.7 Macrophage Cells ◽  
Low Density Lipoprotein Oxidation

Oxidation of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis. Hemin (iron (III)-protoporphyrin IX) is a degradation product of hemoglobin that can be found in thalassemia patients. Hemin is a strong oxidant that can cause LDL oxidation and contributes to atherosclerosis in thalassemia patients. Lusianthridin from Dendrobium venustrum is a phenolic compound that possesses antioxidant activity. Hence, lusianthridin could be a promising compound to be used against hemin-induced oxidative stress. The major goal of this study is to evaluate the protective effect of lusianthridin on hemin-induced low-density lipoprotein oxidation (he-oxLDL). Here, various concentrations of lusianthridin (0.25, 0.5, 1, and 2 µM) were preincubated with LDL for 30 min, then 5 µM of hemin was added to initiate the oxidation, and oxidative parameters were measured at various times of incubation (0, 1, 3, 6, 12, 24 h). Lipid peroxidation of LDL was measured by thiobarbituric reactive substance (TBARs) assay and relative electrophoretic mobility (REM). The lipid composition of LDL was analyzed by using reverse-phase HPLC. Foam cell formation with he-oxLDL in RAW 264.7 macrophage cells was detected by Oil Red O staining. The results indicated that lusianthridin could inhibit TBARs formation, decrease REM, decrease oxidized lipid products, as well as preserve the level of cholesteryl arachidonate and cholesteryl linoleate. Moreover, He-oxLDL incubated with lusianthridin for 24 h can reduce the foam cell formation in RAW 264.7 macrophage cells. Taken together, lusianthridin could be a potential agent to be used to prevent atherosclerosis in thalassemia patients.

scholarly journals Inflammatory process in atherogenesis: New facts about old flame

2012 ◽  
Vol 65 (9-10) ◽  
pp. 388-395 ◽  
Author(s):  
Danijela Vucevic ◽  
Djordje Radak ◽  
Tatjana Radosavljevic ◽  
Dusan Mladenovic ◽  
Ivan Milovanovic
Keyword(s):  
Smooth Muscle ◽  
Endothelial Dysfunction ◽  
Smooth Muscle Cells ◽  
Inflammatory Process ◽  
Foam Cell ◽  
Muscle Cells ◽  
Low Density Lipoproteins ◽  
Foam Cell Formation ◽  
Low Density ◽  
Mediators Of Inflammation

Introduction. Atherosclerosis is a progressive, multifactorial, diffuse, multisystemic, chronic, inflammatory disease, which is manifested by disorders of vascular, immune and metabolic system. Pathogenesis of this disease is not fully understood. Endothelial Dysfunction and Inflammatory Process. Endothelial dysfunction is recognized as the crucial step in atherogenesis. A lot of studies have confirmed the involvement of various mediators of inflammation in initial proatherogenic processes, such as the upregulation of adhesion molecules on endothelial cells, binding of low density lipoproteins to endothelium, activation of macrophages and proliferation of vascular smooth muscle cells. Fatty stain and Inflammatory Process. Fatty stain consists of foam cell accumulation. After foam cell formation, mediators of inflammation initiate a series of intracellular events that include the induction of inflammatory cytokines. Thus, a vicious circle of inflammation, modification of lipoproteins and further inflammation can be maintained in the artery. Transitory Lesion and Inflammatory Process. In transitory lesion intensive phagocytosis of oxidized low density lipoproteins additionally activates monocytes and macrophages and consequently facilitates and exacerbates the inflammatory response. Fibrotic Plaque and Inflammatory Process. Inflammatory process, matrix-degrading metalloproteinases activity, platelets aggregation and smooth muscle cells proliferation play a central role in development of fibrotic plaque. Complex Lesion and Inflammatory Process. It has been shown that inflammation is closely related to the development of atherosclerotic plaque rupture. Conclusion. The contribution of inflammatory process has become increasingly meaningful in understanding the initiation, progression and clinical manifestations of atherosclerosis.

scholarly journals Effects of Very Low Density Lipoprotein from Watanabe Heritable Hyperlipidemic Rabbits on Foam Cell Formation

1988 ◽  
Vol 16 (6) ◽  
pp. 877-879
Author(s):  
Kenji ISHII ◽  
Toru KITA ◽  
Yutaka NAGANO ◽  
Noriaki KUME ◽  
Masayuki YOKODE ◽  
...  
Keyword(s):  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Very Low Density Lipoprotein ◽  
Low Density
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