scholarly journals Path to the Clinic: Assessment of iPSC-Based Cell Therapies In Vivo in a Nonhuman Primate Model

Cell Reports ◽  
2014 ◽  
Vol 7 (4) ◽  
pp. 1298-1309 ◽  
Author(s):  
So Gun Hong ◽  
Thomas Winkler ◽  
Chuanfeng Wu ◽  
Vicky Guo ◽  
Stefania Pittaluga ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Cell Therapies

scholarly journals Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS

2016 ◽  
Vol 3 ◽  
pp. 16007 ◽  
Author(s):  
Christopher W. Peterson ◽  
Kevin G. Haworth ◽  
Bryan P. Burke ◽  
Patricia Polacino ◽  
Krystin K. Norman ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
In Vivo Selection ◽  
Shiv Infection

1338 A NONHUMAN PRIMATE MODEL OF URINARY SPHINCTER DEFICIENCY: PRELUDE TO TESTING CELL THERAPIES

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Sherif Badra ◽  
Gordon McClorie ◽  
Mohamed Sherif Mourad ◽  
J. Koudy Williams
Keyword(s):  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Cell Therapies ◽  
Urinary Sphincter ◽  
Sphincter Deficiency

scholarly journals In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration

2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Jeanette M. Metzger ◽  
Colleen F. Moore ◽  
Carissa A. Boettcher ◽  
Kevin G. Brunner ◽  
Rachel A. Fleddermann ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nonhuman Primate ◽  
In Vivo Imaging ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
And Oxidative Stress

scholarly journals Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2498
Author(s):  
Jan B. Stöckl ◽  
Nina Schmid ◽  
Florian Flenkenthaler ◽  
Charis Drummer ◽  
Rüdiger Behr ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Human Testis ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Morphological Alterations ◽  
Age Related ◽  
Cell Niche ◽  
Peritubular Cells

Age-related changes in the human testis may include morphological alterations, disturbed steroidogenesis, and impaired spermatogenesis. However, the specific impact of cell age remains poorly understood and difficult to assess. Testicular peritubular cells fulfill essential functions, including sperm transport, contributions to the spermatogonial stem cell niche, and paracrine interactions within the testis. To study their role in age-associated decline of testicular functions, we performed comprehensive proteome and secretome analyses of repeatedly passaged peritubular cells from Callithrix jacchus. This nonhuman primate model better reflects the human testicular biology than rodents and further gives access to young donors unavailable from humans. Among 5095 identified proteins, 583 were differentially abundant between samples with low and high passage numbers. The alterations indicate a reduced ability of senescent peritubular cells to contract and secrete proteins, as well as disturbances in nuclear factor (NF)-κB signaling and a reduced capacity to handle reactive oxygen species. Since this in vitro model may not exactly mirror all molecular aspects of in vivo aging, we investigated the proteomes and secretomes of testicular peritubular cells from young and old donors. Even though the age-related alterations at the protein level were less pronounced, we found evidence for impaired protein secretion, altered NF-κB signaling, and reduced contractility of these in vivo aged peritubular cells.

5:3747. In vivo evaluation of biomimetic artificial fabric disc for total cervical disc arthroplasty in a nonhuman primate model

2005 ◽  
Vol 5 (4) ◽  
pp. S25
Author(s):  
Yoshihisa Kotani ◽  
Bryan Cunningham ◽  
Kuniyoshi Abumi ◽  
Anton E. Dmitriev ◽  
Niabin Hu ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Cervical Disc ◽  
Cervical Disc Arthroplasty ◽  
Nonhuman Primate Model ◽  
In Vivo Evaluation ◽  
Primate Model ◽  
Disc Arthroplasty

scholarly journals Derivation of Induced Pluripotent Stem Cells from the Baboon: A Nonhuman Primate Model for Preclinical Testing of Stem Cell Therapies

2013 ◽  
Vol 15 (6) ◽  
pp. 495-502 ◽  
Author(s):  
Christopher S. Navara ◽  
Jacey Hornecker ◽  
Douglas Grow ◽  
Shital Chaudhari ◽  
Peter J. Hornsby ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Nonhuman Primate ◽  
Pluripotent Stem Cells ◽  
Stem Cell Therapies ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Preclinical Testing ◽  
Cell Therapies ◽  
Induced Pluripotent

scholarly journals In Vivo Immunomanipulation of Vγ9Vδ2 T Cells with a Synthetic Phosphoantigen in a Preclinical Nonhuman Primate Model

2005 ◽  
Vol 175 (8) ◽  
pp. 5471-5480 ◽  
Author(s):  
Hélène Sicard ◽  
Sophie Ingoure ◽  
Béatrice Luciani ◽  
Claire Serraz ◽  
Jean-Jacques Fournié ◽  
...  
Keyword(s):  
T Cells ◽  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Vγ9vδ2 T Cells

scholarly journals Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer

2014 ◽  
Vol 1 ◽  
pp. 14028 ◽  
Author(s):  
Aurélie Moreau ◽  
Céline Vandamme ◽  
Mercedes Segovia ◽  
Marie Devaux ◽  
Mickaël Guilbaud ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Gene Transfer ◽  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
In Vivo Evaluation ◽  
Primate Model

In Vivo Targeting of DC-SIGN-positive Antigen-presenting Cells in a Nonhuman Primate Model

2007 ◽  
Vol 30 (7) ◽  
pp. 705-714 ◽  
Author(s):  
Cândida F. Pereira ◽  
Ruurd Torensma ◽  
Konnie Hebeda ◽  
Anke Kretz-Rommel ◽  
Susan J. Faas ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Antigen Presenting Cells ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Antigen Presenting
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