scholarly journals Life Extension Factor Klotho Enhances Cognition

Cell Reports ◽  
2014 ◽  
Vol 7 (4) ◽  
pp. 1065-1076 ◽  
Author(s):  
Dena B. Dubal ◽  
Jennifer S. Yokoyama ◽  
Lei Zhu ◽  
Lauren Broestl ◽  
Kurtresha Worden ◽  
...  
Keyword(s):  
Life Extension ◽  
Extension Factor

scholarly journals Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

2015 ◽  
Vol 35 (6) ◽  
pp. 2358-2371 ◽  
Author(s):  
D. B. Dubal ◽  
L. Zhu ◽  
P. E. Sanchez ◽  
K. Worden ◽  
L. Broestl ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Life Extension ◽  
Extension Factor

scholarly journals Regulation of Life Extension Factor Klotho on Depressive-like Behaviors via Modulation of GluN2B Function in the Nucleus Accumbens

2022 ◽  
Author(s):  
Han-jun Wu ◽  
Liu-er Liu ◽  
Wen-ning Wu ◽  
Jin-qiong Zhan ◽  
Yi-heng Li ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Major Depression ◽  
Life Extension ◽  
Spine Density ◽  
Antidepressive Effect ◽  
Beneficial Effects ◽  
Chronic Social Defeat Stress ◽  
Extension Factor ◽  
Specific Antagonist ◽  
Functional Relevance

Abstract Klotho is a life extension factor that has an ability to regulate the function of GluN2B-containing N-methyl-D-aspartate receptors (NMDARs), whose dysfunction in the nucleus accumbens (NAc) underlies critical aspects of the pathophysiology of major depression. Here we study the functional relevance of klotho in the pathogenesis of depression. A chronic social defeat stress paradigm, where mice are either categorized as susceptible or unsusceptible group based on their performance in a social interaction test, was used in this study. We found that the expression of klotho was largely decreased in the NAc of susceptible mice when compared to control or unsusceptible group. Genetic knockdown of klotho in the NAc induced depressive-like behaviors in naive mice, while overexpression of klotho produced an antidepressive effect in normal mice and ameliorated the depressive-like behaviors in susceptible mice. Molecularly, knockdown of klotho in the NAc resulted in selective decreases of total and synaptic GluN2B expression that were identical to susceptible mice. Elevation of klotho in the NAc reversed the reductions of GluN2B expressions, as well as altered synaptic transmission and spine density in the NAc of susceptible mice. Furthermore, blockade of GluN2B with a specific antagonist abolished the beneficial effects of klotho elevation in susceptible mice. Collectively, we demonstrated that klotho in the NAc modulates depressive-like behaviors by regulating the function of GluN2B-containing NMDARs. These results reveal a novel role for klotho in the pathogenesis of depression, opening new insights into the molecular basis of major depression.

Life Extension of Nuclear Power Plants: World Situation and the USA Case

2010 ◽  
pp. 50-56 ◽  
Author(s):  
Pablo T. León ◽  
Loreto Cuesta ◽  
Eduardo Serra ◽  
Luis Yagüe
Keyword(s):  
Nuclear Power ◽  
Power Plants ◽  
Nuclear Power Plants ◽  
Life Extension ◽  
The Usa

Campaign Life Extension of Blast Furnace Offgas System

2020 ◽  
Author(s):  
C. Lopes ◽  
C. Van der Woude ◽  
H. Ghorbani ◽  
J. Luiz de Oliveira ◽  
M. Al-Dojayli ◽  
...  
Keyword(s):  
Blast Furnace ◽  
Life Extension ◽  
Campaign Life

Comparative assessment of rubber steel cables for vertical mine hoists

2020 ◽  
pp. 85-93
Author(s):  
V. E. Perekutnev ◽  
V. V. Zotov
Keyword(s):  
Feasibility Study ◽  
Carrying Capacity ◽  
Load Distribution ◽  
Comparative Assessment ◽  
Life Extension ◽  
Steel Cable ◽  
Motion Stability ◽  
Cable Length ◽  
Steel Cables ◽  
Mine Hoist

Operation of inhaul rubber steel cables in vertical mine hoisting is discussed. The research in the field of mine hoisting is reviewed, and the further R&D directions are identified. Some studies concern life extension of hoisting ropes. One of the promising trends seems to be application of belt pullers as inhaul cables, which can essentially enhance mine hoist efficiency. In the meanwhile, capabilities of rubber steel cables suffer from deficient attention. The performance capabilities of rubber steel cables of top manufacturers (Promkanat and SAG) are compared, and application ranges in vertical mine hoisting are determined for such cables. It is found that the Polish manufacturer’s rubber steel cables offer a wider range of application. The analysis shows that rubber steel cables can be used as inhaul cables of vertical mine hoisters. Rubber steel cables possess suitable characteristics and are capable to elevate considerable loads to various hoisting heights. In particular, the existing rubber steel cables ensure carrying capacity of hoists up to 20-25 t at the hoisting heights to 400-500 m and sometimes can elevate skips with tonnage of 10 t to a height up to 1000 m and more. The further feasibility study of operation of inhaul steel rubber cables in hoisting units should address motion stability of a puller on a driving drum, load distribution in ropes of base of rubber steel cables, validation of hoister design, adjustability of rubber steel cable length during its operation, etc.

Life extension heat treatment of IN 783 bolts

2020 ◽  
Vol 62 (1) ◽  
pp. 49-54
Author(s):  
Qiang Zhao ◽  
Jiaqing Wang ◽  
Junjian Liu ◽  
Yue Wu ◽  
Xiaodong Du
Keyword(s):  
Heat Treatment ◽  
Life Extension
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