scholarly journals Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

Cell Reports ◽  
2014 ◽  
Vol 7 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Chiara Degirolamo ◽  
Stefania Rainaldi ◽  
Fabiola Bovenga ◽  
Stefania Murzilli ◽  
Antonio Moschetta
Keyword(s):  
Bile Acid ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile

scholarly journals Esterified and total 7 alpha-hydroxycholesterol in human serum as an indicator for hepatic bile acid synthesis.

1990 ◽  
Vol 31 (12) ◽  
pp. 2209-2218
Author(s):  
H Oda ◽  
H Yamashita ◽  
K Kosahara ◽  
S Kuroki ◽  
F Nakayama
Keyword(s):  
Bile Acid ◽  
Human Serum ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile

scholarly journals Prostaglandin E2promotes hepatic bile acid synthesis by an E prostanoid receptor 3-mediated hepatocyte nuclear receptor 4α/cholesterol 7α-hydroxylase pathway in mice

Hepatology ◽  
2016 ◽  
Vol 65 (3) ◽  
pp. 999-1014 ◽  
Author(s):  
Shuai Yan ◽  
Juan Tang ◽  
Yuyao Zhang ◽  
Yuanyang Wang ◽  
Shengkai Zuo ◽  
...  
Keyword(s):  
Bile Acid ◽  
Nuclear Receptor ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile ◽  
Prostanoid Receptor

Serum 7 α-hydroxycholesterol as a parameter of hepatic bile acid synthesis in humans

1994 ◽  
Vol 1 ◽  
pp. 168
Author(s):  
S. Kuroki ◽  
T. Naito ◽  
H. Yamashita ◽  
K. Chijiiwa ◽  
M. Tanaka
Keyword(s):  
Bile Acid ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile

scholarly journals Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice

Hepatology ◽  
2019 ◽  
Vol 70 (6) ◽  
pp. 2171-2184 ◽  
Author(s):  
Joanne A. Hoogerland ◽  
Yu Lei ◽  
Justina C. Wolters ◽  
Jan Freark Boer ◽  
Trijnie Bos ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile

Serum 7α–hydroxycholesterol reflects hepatic bile acid synthesis in patients with obstructive jaundice after external biliary drainage

Hepatology ◽  
1994 ◽  
Vol 20 (1) ◽  
pp. 95-100
Author(s):  
Shuichiro Okamoto ◽  
Kazuhisa Fukushima ◽  
Hidetaka Higashijima ◽  
Ichiro Makino ◽  
Masanori Kishinaka ◽  
...  
Keyword(s):  
Bile Acid ◽  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile ◽  
External Biliary Drainage

scholarly journals Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis

Theranostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 4363-4380
Author(s):  
Chao Sun ◽  
Wei Liu ◽  
Zhiqiang Lu ◽  
Yan Li ◽  
Shengnan Liu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Serum Cholesterol ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile ◽  
Cholesterol Levels

Sa1849 Sleeve Gastrectomy in Mice and Humans Results in Weight Loss Independent Suppression of Hepatic Bile Acid Synthesis

2013 ◽  
Vol 144 (5) ◽  
pp. S-319-S-320 ◽  
Author(s):  
Rohit Kohli ◽  
Andriy Myronovych ◽  
Stavra Xanthakos ◽  
Karen K. Ryan ◽  
Todd Jenkins ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Bile Acid ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile

Hepatic bile acid synthesis and DNA synthetic rate after partial hepatectomy

1996 ◽  
Vol 83 (4) ◽  
pp. 482-485 ◽  
Author(s):  
K. Chijiiwa ◽  
N. Kozaki ◽  
T. Naito ◽  
S. Okamoto ◽  
S. Kuroki ◽  
...  
Keyword(s):  
Bile Acid ◽  
Partial Hepatectomy ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile ◽  
Synthetic Rate

A nontumorigenic variant of FGF19 treats cholestatic liver diseases

2014 ◽  
Vol 6 (247) ◽  
pp. 247ra100-247ra100 ◽  
Author(s):  
Jian Luo ◽  
Brian Ko ◽  
Michael Elliott ◽  
Mei Zhou ◽  
Darrin A. Lindhout ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Diseases ◽  
Acid Metabolism ◽  
Prolonged Exposure ◽  
Surrogate Marker ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Bile Acid Metabolism ◽  
Hepatic Bile ◽  
Healthy Human

Hepatic accumulation of bile acids is central to the pathogenesis of cholestatic liver diseases. Endocrine hormone fibroblast growth factor 19 (FGF19) may reduce hepatic bile acid levels through modulation of bile acid synthesis and prevent subsequent liver damage. However, FGF19 has also been implicated in hepatocellular carcinogenesis, and consequently, the potential risk from prolonged exposure to supraphysiological levels of the hormone represents a major hurdle for developing an FGF19-based therapy. We describe a nontumorigenic FGF19 variant, M70, which regulates bile acid metabolism and, through inhibition of bile acid synthesis and reduction of excess hepatic bile acid accumulation, protects mice from liver injury induced by either extrahepatic or intrahepatic cholestasis. Administration of M70 in healthy human volunteers potently reduces serum levels of 7α-hydroxy-4-cholesten-3-one, a surrogate marker for the hepatic activity of cholesterol 7α-hydroxylase (CYP7A1), the enzyme responsible for catalyzing the first and rate-limiting step in the classical bile acid synthetic pathway. This study provides direct evidence for the regulation of bile acid metabolism by FGF19 pathway in humans. On the basis of these results, the development of nontumorigenic FGF19 variants capable of modulating CYP7A1 expression represents an effective approach for the prevention and treatment of cholestatic liver diseases as well as potentially for other disorders associated with bile acid dysregulation.

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