scholarly journals Regulation of Chandelier Cell Cartridge and Bouton Development via DOCK7-Mediated ErbB4 Activation

Cell Reports ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. 254-263 ◽  
Author(s):  
Yilin Tai ◽  
Justyna A. Janas ◽  
Chia-Lin Wang ◽  
Linda Van Aelst
Keyword(s):  
Chandelier Cell

scholarly journals Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex

Neuron ◽  
2020 ◽  
Author(s):  
Bor-Shuen Wang ◽  
Maria Sol Bernardez Sarria ◽  
Xu An ◽  
Miao He ◽  
Nazia M. Alam ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Chandelier Cell ◽  
Activity Dependent

scholarly journals Chandelier cell anatomy and function reveal a variably distributed but common signal

2020 ◽  
Author(s):  
Casey M. Schneider-Mizell ◽  
Agnes L. Bodor ◽  
Forrest Collman ◽  
Derrick Brittain ◽  
Adam A. Bleckert ◽  
...  
Keyword(s):  
Large Scale ◽  
Pyramidal Neurons ◽  
Cell Activity ◽  
Cortical Cell ◽  
Cell Types ◽  
Structural Features ◽  
Target Neuron ◽  
Chandelier Cell ◽  
Chandelier Cells

AbstractThe activity and connectivity of inhibitory cells has a profound impact on the operation of neuronal networks. While the average connectivity of many inhibitory cell types has been characterized, we still lack an understanding of how individual interneurons distribute their synapses onto their targets and how heterogeneous the inhibition is onto different individual excitatory neurons. Here, we use large-scale volumetric electron microscopy (EM) and functional imaging to address this question for chandelier cells in layer 2/3 of mouse visual cortex. Using dense morphological reconstructions from EM, we mapped the complete chandelier input onto 153 pyramidal neurons. We find that the number of input synapses is highly variable across the population, but the variability is correlated with structural features of the target neuron: soma depth, soma size, and the number of perisomatic synapses received. Functionally, we found that chandelier cell activity in vivo was highly correlated and tracks pupil diameter, a proxy for arousal state. We propose that chandelier cells provide a global signal whose strength is individually adjusted for each target neuron. This approach, combining comprehensive structural analysis with functional recordings of identified cell types, will be a powerful tool to uncover the wiring rules across the diversity of cortical cell types.

scholarly journals Selective Alterations in Postsynaptic Markers of Chandelier Cell Inputs to Cortical Pyramidal Neurons in Subjects with Schizophrenia

2009 ◽  
Vol 34 (9) ◽  
pp. 2112-2124 ◽  
Author(s):  
Dianne A Cruz ◽  
Cassandra L Weaver ◽  
Emily M Lovallo ◽  
Darlene S Melchitzky ◽  
David A Lewis
Keyword(s):  
Pyramidal Neurons ◽  
Chandelier Cell ◽  
Cortical Pyramidal Neurons

scholarly journals Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders

2020 ◽  
Vol 43 (8) ◽  
pp. 565-580
Author(s):  
Nicholas B. Gallo ◽  
Anirban Paul ◽  
Linda Van Aelst
Keyword(s):  
Cell Development ◽  
Chandelier Cell ◽  
Neural Disorders
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