scholarly journals Aurora A Kinase Regulates Mammary Epithelial Cell Fate by Determining Mitotic Spindle Orientation in a Notch-Dependent Manner

Cell Reports ◽  
2013 ◽  
Vol 4 (1) ◽  
pp. 110-123 ◽  
Author(s):  
Joseph L. Regan ◽  
Tony Sourisseau ◽  
Kelly Soady ◽  
Howard Kendrick ◽  
Afshan McCarthy ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Fate ◽  
Mitotic Spindle ◽  
Mammary Epithelial Cell ◽  
Mammary Epithelial ◽  
Spindle Orientation ◽  
Dependent Manner ◽  
Aurora A Kinase ◽  
Aurora A

scholarly journals Tracing anti-cancer and cancer-promoting actions of all-trans retinoic acid in breast cancer to a RARa epigenetic mechanism of mammary epithelial cell fate

Oncotarget ◽  
2016 ◽  
Vol 7 (52) ◽  
pp. 87064-87080 ◽  
Author(s):  
Stefano Rossetti ◽  
MingQiang Ren ◽  
Nicolo Visconti ◽  
Francesca Corlazzoli ◽  
Vincenzo Gagliostro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Epithelial Cell ◽  
Cell Fate ◽  
Mammary Epithelial Cell ◽  
Mammary Epithelial ◽  
Epigenetic Mechanism ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Anti Cancer

scholarly journals Runx2 Is a Novel Regulator of Mammary Epithelial Cell Fate in Development and Breast Cancer

2014 ◽  
Vol 74 (18) ◽  
pp. 5277-5286 ◽  
Author(s):  
Thomas W. Owens ◽  
Renee L. Rogers ◽  
Sarah A. Best ◽  
Anita Ledger ◽  
Anne-Marie Mooney ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cell ◽  
Cell Fate ◽  
Mammary Epithelial Cell ◽  
Mammary Epithelial

Centrosome Aurora A gradient ensures single polarity axis in C. elegans embryos

2020 ◽  
Vol 48 (3) ◽  
pp. 1243-1253 ◽  
Author(s):  
Sukriti Kapoor ◽  
Sachin Kotak
Keyword(s):  
Symmetry Breaking ◽  
Cell Fate ◽  
Cell Cortex ◽  
Axis Formation ◽  
Aurora A Kinase ◽  
Aurora A ◽  
C Elegans ◽  
Cell Embryo ◽  
Polarity Establishment

Cellular asymmetries are vital for generating cell fate diversity during development and in stem cells. In the newly fertilized Caenorhabditis elegans embryo, centrosomes are responsible for polarity establishment, i.e. anterior–posterior body axis formation. The signal for polarity originates from the centrosomes and is transmitted to the cell cortex, where it disassembles the actomyosin network. This event leads to symmetry breaking and the establishment of distinct domains of evolutionarily conserved PAR proteins. However, the identity of an essential component that localizes to the centrosomes and promotes symmetry breaking was unknown. Recent work has uncovered that the loss of Aurora A kinase (AIR-1 in C. elegans and hereafter referred to as Aurora A) in the one-cell embryo disrupts stereotypical actomyosin-based cortical flows that occur at the time of polarity establishment. This misregulation of actomyosin flow dynamics results in the occurrence of two polarity axes. Notably, the role of Aurora A in ensuring a single polarity axis is independent of its well-established function in centrosome maturation. The mechanism by which Aurora A directs symmetry breaking is likely through direct regulation of Rho-dependent contractility. In this mini-review, we will discuss the unconventional role of Aurora A kinase in polarity establishment in C. elegans embryos and propose a refined model of centrosome-dependent symmetry breaking.

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