scholarly journals Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice

Cell Reports ◽  
2012 ◽  
Vol 2 (6) ◽  
pp. 1498-1504 ◽  
Author(s):  
Tianyi Zhang ◽  
Kay Penicud ◽  
Christopher Bruhn ◽  
Joanna I. Loizou ◽  
Nnennaya Kanu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Pathway Choice ◽  
Atm Signaling Pathway ◽  
Atm Signaling

scholarly journals INTS3 controls the hSSB1-mediated DNA damage response

2009 ◽  
Vol 187 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Jeffrey R. Skaar ◽  
Derek J. Richard ◽  
Anita Saraf ◽  
Alfredo Toschi ◽  
Emma Bolderson ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Response ◽  
Ataxia Telangiectasia ◽  
Binding Protein ◽  
Ataxia Telangiectasia Mutated ◽  
Uncharacterized Protein ◽  
Damage Response ◽  
Atm Signaling Pathway ◽  
Atm Signaling

Human SSB1 (single-stranded binding protein 1 [hSSB1]) was recently identified as a part of the ataxia telangiectasia mutated (ATM) signaling pathway. To investigate hSSB1 function, we performed tandem affinity purifications of hSSB1 mutants mimicking the unphosphorylated and ATM-phosphorylated states. Both hSSB1 mutants copurified a subset of Integrator complex subunits and the uncharacterized protein LOC58493/c9orf80 (henceforth minute INTS3/hSSB-associated element [MISE]). The INTS3–MISE–hSSB1 complex plays a key role in ATM activation and RAD51 recruitment to DNA damage foci during the response to genotoxic stresses. These effects on the DNA damage response are caused by the control of hSSB1 transcription via INTS3, demonstrating a new network controlling hSSB1 function.

scholarly journals Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

2009 ◽  
Vol 37 (16) ◽  
pp. 5353-5364 ◽  
Author(s):  
Angela Rizzo ◽  
Erica Salvati ◽  
Manuela Porru ◽  
Carmen D’Angelo ◽  
Malcolm F. Stevens ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Quadruplex Dna ◽  
Telomere Replication ◽  
Atm Signaling Pathway ◽  
Atm Signaling

scholarly journals ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells

2017 ◽  
Vol 17 (4) ◽  
pp. 295 ◽  
Author(s):  
Lei Wang ◽  
Qiu-Tong Wang ◽  
Yu-Peng Liu ◽  
Qing-Qing Dong ◽  
Hai-Jie Hu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Gastric Cancer Cells ◽  
And Migration ◽  
Atm Signaling Pathway ◽  
Atm Signaling ◽  
Proliferation And Migration

Sodium glycididazole enhances the radiosensitivity of laryngeal cancer cells through downregulation of ATM signaling pathway

Tumor Biology ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 5869-5878 ◽  
Author(s):  
Yue-Can Zeng ◽  
Rui Xing ◽  
Jing Zeng ◽  
Ming Xue ◽  
Feng Chi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Signaling Pathway ◽  
Laryngeal Cancer ◽  
Atm Signaling Pathway ◽  
Atm Signaling

scholarly journals Oncogenes and the DNA Damage Response: Myc and E2F1 Engage the ATM Signaling Pathway to Activate p53 and Induce Apoptosis

Cell Cycle ◽  
2006 ◽  
Vol 5 (8) ◽  
pp. 801-803 ◽  
Author(s):  
Sungki Hong ◽  
Raju V. Pusapati ◽  
John T. Powers ◽  
David G. Johnson
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Response ◽  
Damage Response ◽  
Atm Signaling Pathway ◽  
Atm Signaling

Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway

2011 ◽  
Vol 81 (5) ◽  
pp. 594-605 ◽  
Author(s):  
Li-Hsin Chen ◽  
Che-Chuan Loong ◽  
Tsann-Long Su ◽  
Yi-Jang Lee ◽  
Pei-Ming Chu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Atm Signaling Pathway ◽  
Atm Signaling ◽  
Autophagy Inhibition
Sign in / Sign up

Export Citation Format

Share Document