A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions

Itsunari Minami; Kohei Yamada; Tomomi G. Otsuji; Takuya Yamamoto; Yan Shen; Shinya Otsuka; Shin Kadota; Nobuhiro Morone; Maneesha Barve; Yasuyuki Asai; Tatyana Tenkova-Heuser; John E. Heuser; Motonari Uesugi; Kazuhiro Aiba; Norio Nakatsuji

doi:10.1016/j.celrep.2012.09.015

A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions

Cell Reports ◽

10.1016/j.celrep.2012.09.015 ◽

2012 ◽

Vol 2 (5) ◽

pp. 1448-1460 ◽

Cited By ~ 165

Author(s):

Itsunari Minami ◽

Kohei Yamada ◽

Tomomi G. Otsuji ◽

Takuya Yamamoto ◽

Yan Shen ◽

...

Keyword(s):

Stem Cells ◽

Small Molecule ◽

Pluripotent Stem Cells ◽

Human Pluripotent Stem Cells ◽

Cardiac Differentiation

Download Full-text

Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells

Journal of Molecular and Cellular Cardiology ◽

10.1016/j.yjmcc.2011.04.012 ◽

2011 ◽

Vol 51 (3) ◽

pp. 280-287 ◽

Cited By ~ 104

Author(s):

Yongming Ren ◽

Min Young Lee ◽

Simon Schliffke ◽

Jere Paavola ◽

Peter J. Amos ◽

...

Keyword(s):

Stem Cells ◽

Small Molecule ◽

Pluripotent Stem Cells ◽

Human Pluripotent Stem Cells ◽

Cardiac Differentiation ◽

Wnt Inhibitors

Download Full-text

Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

Stem Cell Reports ◽

10.1016/j.stemcr.2015.04.001 ◽

2015 ◽

Vol 4 (5) ◽

pp. 939-952 ◽

Cited By ~ 98

Author(s):

Richard Siller ◽

Sebastian Greenhough ◽

Elena Naumovska ◽

Gareth J. Sullivan

Keyword(s):

Stem Cells ◽

Small Molecule ◽

Pluripotent Stem Cells ◽

Human Pluripotent Stem Cells ◽

Hepatocyte Differentiation

Download Full-text

Insulin Inhibits Cardiac Mesoderm, Not Mesendoderm, Formation During Cardiac Differentiation of Human Pluripotent Stem Cells and Modulation of Canonical Wnt Signaling Can Rescue This Inhibition

Stem Cells ◽

10.1002/stem.1289 ◽

2013 ◽

Vol 31 (3) ◽

pp. 447-457 ◽

Cited By ~ 38

Author(s):

Xiaojun Lian ◽

Jianhua Zhang ◽

Kexian Zhu ◽

Timothy J. Kamp ◽

Sean P. Palecek

Keyword(s):

Stem Cells ◽

Wnt Signaling ◽

Pluripotent Stem Cells ◽

Human Pluripotent Stem Cells ◽

Cardiac Differentiation ◽

Canonical Wnt Signaling ◽

Canonical Wnt ◽

Cardiac Mesoderm

Download Full-text

Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells

Stem Cell Research ◽

10.1016/j.scr.2017.08.010 ◽

2017 ◽

Vol 24 ◽

pp. 61-68 ◽

Cited By ~ 2

Author(s):

Azuma Kimura ◽

Taro Toyoda ◽

Yohei Nishi ◽

Makoto Nasu ◽

Akira Ohta ◽

...

Keyword(s):

Stem Cells ◽

Progenitor Cells ◽

Small Molecule ◽

Pluripotent Stem Cells ◽

Human Pluripotent Stem Cells ◽

Pancreatic Progenitor ◽

Pancreatic Progenitor Cells

Download Full-text

A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells

Angewandte Chemie ◽

10.1002/ange.201206691 ◽

2012 ◽

Vol 124 (50) ◽

pp. 12677-12681 ◽

Cited By ~ 1

Author(s):

Jungwoon Lee ◽

Yan Xia ◽

Mi-Young Son ◽

Guanghai Jin ◽

Binna Seol ◽

...

Keyword(s):

Stem Cells ◽

Small Molecule ◽

Pluripotent Stem Cells ◽

Somatic Cells ◽

Human Pluripotent Stem Cells ◽

Pluripotent State ◽

Undifferentiated State

Download Full-text

Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells

Journal of Neuroscience Research ◽

10.1002/jnr.22547 ◽

2010 ◽

Vol 89 (2) ◽

pp. 117-126 ◽

Cited By ~ 104

Author(s):

Asuka Morizane ◽

Daisuke Doi ◽

Tetsuhiro Kikuchi ◽

Kaneyasu Nishimura ◽

Jun Takahashi

Keyword(s):

Stem Cells ◽

Small Molecule ◽

Pluripotent Stem Cells ◽

Small Molecule Inhibitors ◽

Neural Induction ◽

Human Pluripotent Stem Cells ◽

Bone Morphogenic Protein ◽

Highly Efficient

Download Full-text

Small molecule induction promotes corneal epithelial cell differentiation from human pluripotent stem cells

Acta Ophthalmologica ◽

10.1111/j.1755-3768.2013.2473.x ◽

2013 ◽

Vol 91 ◽

pp. 0-0

Author(s):

H SKOTTMAN ◽

A MIKHAILOVA ◽

H UUSITALO ◽

T ILMARINEN

Keyword(s):

Stem Cells ◽

Cell Differentiation ◽

Epithelial Cell ◽

Small Molecule ◽

Pluripotent Stem Cells ◽

Human Pluripotent Stem Cells ◽

Corneal Epithelial Cell ◽

Corneal Epithelial ◽

Epithelial Cell Differentiation

Download Full-text

Fetal Reprogramming and Senescence in Hypoplastic Left Heart Syndrome and in Human Pluripotent Stem Cells during Cardiac Differentiation

American Journal Of Pathology ◽

10.1016/j.ajpath.2013.05.022 ◽

2013 ◽

Vol 183 (3) ◽

pp. 720-734 ◽

Cited By ~ 32

Author(s):

Naila Gaber ◽

Mark Gagliardi ◽

Pranali Patel ◽

Caroline Kinnear ◽

Cindy Zhang ◽

...

Keyword(s):

Stem Cells ◽

Hypoplastic Left Heart Syndrome ◽

Pluripotent Stem Cells ◽

Human Pluripotent Stem Cells ◽

Cardiac Differentiation ◽

Left Heart ◽

Hypoplastic Left Heart ◽

Fetal Reprogramming ◽

Left Heart Syndrome

Download Full-text

Highly efficient and expedited hepatic differentiation from human pluripotent stem cells by pure small-molecule cocktails

Stem Cell Research & Therapy ◽

10.1186/s13287-018-0794-4 ◽

2018 ◽

Vol 9 (1) ◽

Cited By ~ 15

Author(s):

Cong Du ◽

Yuan Feng ◽

Dongbo Qiu ◽

Yan Xu ◽

Mao Pang ◽

...

Keyword(s):

Stem Cells ◽

Small Molecule ◽

Pluripotent Stem Cells ◽

Human Pluripotent Stem Cells ◽

Hepatic Differentiation ◽

Highly Efficient

Download Full-text

Aggregate Size Optimization in Microwells for Suspension-based Cardiac Differentiation of Human Pluripotent Stem Cells

Journal of Visualized Experiments ◽

10.3791/54308 ◽

2016 ◽

Cited By ~ 5

Author(s):

Celine L. Bauwens ◽

Derek Toms ◽

Mark Ungrin

Keyword(s):

Stem Cells ◽

Pluripotent Stem Cells ◽

Aggregate Size ◽

Human Pluripotent Stem Cells ◽

Cardiac Differentiation ◽

Size Optimization

Download Full-text