Fibroblast growth factor type 1 receptor stimulation of T-type Ca2+ channels in sensory neurons requires the phosphatidylinositol 3-kinase and protein kinase A pathways, independently of Akt

2018 ◽  
Vol 45 ◽  
pp. 93-101 ◽  
Author(s):  
Weibing Si ◽  
Yuan Zhang ◽  
Kun Chen ◽  
Dan Hu ◽  
Zhiyuan Qian ◽  
...  
Keyword(s):  
Growth Factor ◽  
Sensory Neurons ◽  
Fibroblast Growth ◽  
Phosphatidylinositol 3 Kinase ◽  
Receptor Stimulation ◽  
Factor Type ◽  
Ca2 Channels ◽  
Kinase A ◽  
Stimulation Of

scholarly journals Transactivation of the Insulin-Like Growth Factor-I Receptor by Angiotensin II Mediates Downstream Signaling from the Angiotensin II Type 1 Receptor to Phosphatidylinositol 3-Kinase

Endocrinology ◽  
2004 ◽  
Vol 145 (6) ◽  
pp. 2978-2987 ◽  
Author(s):  
Peter Zahradka ◽  
Brenda Litchie ◽  
Ben Storie ◽  
Gail Helwer
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Growth Factor ◽  
Pi3 Kinase ◽  
Phosphatidylinositol 3 Kinase ◽  
Receptor Phosphorylation ◽  
Kinase Activation ◽  
Igf I ◽  
Stimulation Of

Abstract Angiotensin II (AngII) activates phosphatidylinositol 3-kinase (PI3-kinase), a known effector of receptor tyrosine kinases. Treatment of smooth muscle cells with AngII has also been shown to promote phosphorylation of various tyrosine kinase receptors. We therefore investigated the relationship between AngII and IGF-I receptor activation in smooth muscle cells with a phosphorylation-specific antibody. Our experiments showed that IGF-I receptor phosphorylation was maximally stimulated within 10 min by AngII. Inclusion of an IGF-I-neutralizing antibody in the culture media did not prevent IGF-I receptor phosphorylation after AngII treatment, which argues that a paracrine/autocrine loop is not required. Furthermore, this process was blocked by losartan and 1-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (PP-1), indicating stimulation of IGF-I receptor phosphorylation occurs via AngII type 1 receptor-dependent activation of Src kinase. The functional significance of IGF-I receptor transactivation was examined with selective inhibitors of the IGF-I receptor kinase (AG1024, AG538). When AngII-treated cells were incubated with AG1024 or AG538, phosphorylation of the regulatory p85 subunit of PI3-kinase was blocked. Furthermore, phosphorylation of the downstream factor p70S6K did not occur. In contrast, AG1024 did not prevent MAPK or Src kinase activation by AngII. AG1024 also did not inhibit AngII-dependent cell migration, although this process was blocked by inhibitors of the epidermal growth factor and platelet-derived growth factor receptors. Transactivation of the IGF-I receptor is therefore a critical mediator of PI3-kinase activation by AngII but is not required for stimulation of the MAPK cascade.

Fibroblast Growth Factor Type 1 (FGF1)-Overexpressed Adipose-Derived Mesenchaymal Stem Cells (AD-MSCFGF1) Induce Neuroprotection and Functional Recovery in a Rat Stroke Model

2017 ◽  
Vol 13 (5) ◽  
pp. 670-685 ◽  
Author(s):  
Hamed Ghazavi ◽  
Seyed Javad Hoseini ◽  
Alireza Ebrahimzadeh-Bideskan ◽  
Baratali Mashkani ◽  
Soghra Mehri ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Functional Recovery ◽  
Fibroblast Growth ◽  
Stroke Model ◽  
Factor Type

scholarly journals Role of Fibroblast Growth Factor Type 1 and 2 in Carbon Tetrachloride-Induced Hepatic Injury and Fibrogenesis

2003 ◽  
Vol 163 (4) ◽  
pp. 1653-1662 ◽  
Author(s):  
Chundong Yu ◽  
Fen Wang ◽  
Chengliu Jin ◽  
Xinqiang Huang ◽  
David L. Miller ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hepatic Injury ◽  
Fibroblast Growth ◽  
Factor Type

scholarly journals Neuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity

Theranostics ◽  
2021 ◽  
Vol 11 (19) ◽  
pp. 9342-9357
Author(s):  
Yuan Zhang ◽  
Zhiyuan Qian ◽  
Dongsheng Jiang ◽  
Yufang Sun ◽  
Shangshang Gao ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
Receptor Stimulation ◽  
Pain Hypersensitivity ◽  
Peripheral Pain ◽  
Neuromedin B ◽  
Ca2 Channels ◽  
Stimulation Of
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