scholarly journals Tyrosines-740/751 of PDGFRβ contribute to the activation of Akt/Hif1α/TGFβ nexus to drive high glucose-induced glomerular mesangial cell hypertrophy

2018 ◽  
Vol 42 ◽  
pp. 44-53 ◽  
Author(s):  
Falguni Das ◽  
Nandini Ghosh-Choudhury ◽  
Balakuntalam S. Kasinath ◽  
Goutam Ghosh Choudhury
Keyword(s):  
High Glucose ◽  
Mesangial Cell ◽  
Glomerular Mesangial Cell ◽  
Cell Hypertrophy

scholarly journals Deacetylation of S6 kinase promotes high glucose–induced glomerular mesangial cell hypertrophy and matrix protein accumulation

2019 ◽  
Vol 294 (24) ◽  
pp. 9440-9460 ◽  
Author(s):  
Falguni Das ◽  
Soumya Maity ◽  
Nandini Ghosh-Choudhury ◽  
Balakuntalam S. Kasinath ◽  
Goutam Ghosh Choudhury
Keyword(s):  
High Glucose ◽  
Matrix Protein ◽  
Mesangial Cell ◽  
Protein Accumulation ◽  
Glomerular Mesangial Cell ◽  
S6 Kinase ◽  
Cell Hypertrophy

scholarly journals PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy

2010 ◽  
Vol 225 (1) ◽  
pp. 27-41 ◽  
Author(s):  
Nirmalya Dey ◽  
Nandini Ghosh-Choudhury ◽  
Falguni Das ◽  
Xiaonan Li ◽  
Balachandar Venkatesan ◽  
...  
Keyword(s):  
High Glucose ◽  
Mesangial Cell ◽  
Glomerular Mesangial Cell ◽  
Cell Hypertrophy

High glucose-stimulated enhancer of zeste homolog-2 (EZH2) forces suppression of deptor to cause glomerular mesangial cell pathology

2021 ◽  
pp. 110072
Author(s):  
Falguni Das ◽  
Amit Bera ◽  
Nandini Ghosh-Choudhury ◽  
Kavitha Sataranatarajan ◽  
Amrita Kamat ◽  
...  
Keyword(s):  
High Glucose ◽  
Mesangial Cell ◽  
Glomerular Mesangial Cell ◽  
Enhancer Of Zeste

scholarly journals LncRNA NEAT1 Promotes High Glucose-Induced Mesangial Cell Hypertrophy by Targeting miR-222-3p/CDKN1B Axis

2021 ◽  
Vol 7 ◽  
Author(s):  
Lin Liao ◽  
Jie Chen ◽  
Chuanfu Zhang ◽  
Yue Guo ◽  
Weiwei Liu ◽  
...  
Keyword(s):  
High Glucose ◽  
Noncoding Rna ◽  
Mesangial Cell ◽  
Mesangial Cells ◽  
Morphological Alteration ◽  
Glomerular Hypertrophy ◽  
Cell Hypertrophy ◽  
Rna Immunoprecipitation ◽  
Lncrna Neat1

Glomerular hypertrophy is an early morphological alteration in diabetic nephropathy. Cyclin-Dependent Kinases have been shown to be required for high glucose (HG)-induced hypertrophy; however, the upstream regulators of CDKN1B in glomerular hypertrophy remain unclear. Herein we describe a novel pathway in which Long noncoding RNA (lncRNA) NEAT1 regulates the progression of mesangial cell hypertrophy via a competing endogenous RNA (ceRNA) mechanism. Real-time PCR was performed to detect the relative NEAT1 and miR-222-3p expressions and further confirmed the relationship between NEAT1 and miR-222-3p. Cell cycle was evaluated by flow cytometry. The related mechanisms were explored by Western blot, RNA immunoprecipitation and chromatin immunoprecipitation assay. We show that NEAT1 forms double stranded RNA (dsRNA) with miR-222-3p, thus limiting miR-222-3p’s binding with CDKN1B. This release of CDKN1B mRNA leads to elevated CDKN1B protein expression, resulting in hypertrophy. In addition, we demonstrated that STAT3 which is activated by HG induces the transcription of NEAT1 by binding to its promoter. Our findings underscore an unexpected role of lncRNAs on gene regulation and introduce a new mode of proliferation regulation in mesangial cells.

scholarly journals Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN

Diabetes ◽  
2006 ◽  
Vol 55 (7) ◽  
pp. 2115-2125 ◽  
Author(s):  
L. Mahimainathan ◽  
F. Das ◽  
B. Venkatesan ◽  
G. G. Choudhury
Keyword(s):  
Tumor Suppressor ◽  
High Glucose ◽  
Mesangial Cell ◽  
Cell Hypertrophy

scholarly journals High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy

2011 ◽  
Vol 23 (8) ◽  
pp. 1311-1319 ◽  
Author(s):  
Falguni Das ◽  
Nirmalya Dey ◽  
Balachandar Venkatesan ◽  
Balakuntalam S. Kasinath ◽  
Nandini Ghosh-Choudhury ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Glucose ◽  
Early Onset ◽  
Mesangial Cell ◽  
Cell Hypertrophy ◽  
Disease Protein ◽  
Early Onset Parkinson’S Disease

Glomerular Mesangial Cell Altered Contractility in High Glucose Is Ca2+ Independent

Diabetes ◽  
1995 ◽  
Vol 44 (7) ◽  
pp. 759-766 ◽  
Author(s):  
R. D. Hurst ◽  
Z. S. Stevanovic ◽  
S. Munk ◽  
B. Derylo ◽  
X. Zhou ◽  
...  
Keyword(s):  
High Glucose ◽  
Mesangial Cell ◽  
Glomerular Mesangial Cell

scholarly journals The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathy: potential role in glomerular hypertrophy.

1998 ◽  
Vol 9 (6) ◽  
pp. 986-993 ◽  
Author(s):  
C J Kuan ◽  
M al-Douahji ◽  
S J Shankland
Keyword(s):  
Cell Cycle ◽  
Diabetic Nephropathy ◽  
High Glucose ◽  
Mesangial Cell ◽  
Kinase Inhibitor ◽  
Glomerular Hypertrophy ◽  
Glomerular Cell ◽  
Cyclin Dependent Kinases ◽  
Cell Hypertrophy

High glucose inhibits mesangial cell proliferation in vitro and induces hypertrophy in mesangial cells in culture and in experimental diabetic nephropathy. Cell growth is ultimately controlled at the level of the cell cycle by cell cycle regulatory proteins. Cell cycle progression requires that cyclin-dependent kinases be activated by cyclins. Cyclin kinase inhibitors (CKI) inactivate cyclin-dependent kinases, causing cell cycle arrest. In the current study, high glucose-induced mesangial cell hypertrophy in vitro is shown to be associated with increased levels of the CKI p21, but not p27. In the streptozotocin model of experimental diabetes in the mouse, glomerular hypertrophy was associated with a selective increase in p21 expression, whereas the levels of the CKI p27 and p57 did not change. Unlike many other forms of glomerular injury, diabetic nephropathy was not associated with increased apoptosis. These results support a role for p21 in causing glomerular cell hypertrophy in diabetic nephropathy.

scholarly journals High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression

2015 ◽  
Vol 27 (7) ◽  
pp. 1276-1285 ◽  
Author(s):  
Nirmalya Dey ◽  
Amit Bera ◽  
Falguni Das ◽  
Nandini Ghosh-Choudhury ◽  
Balakuntalam S. Kasinath ◽  
...  
Keyword(s):  
Protein Expression ◽  
High Glucose ◽  
Matrix Protein ◽  
Mesangial Cell ◽  
Cell Hypertrophy
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