WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways

2016 ◽  
Vol 28 (11) ◽  
pp. 1673-1682 ◽  
Author(s):  
Jin Meng ◽  
Xu-Tao Zhang ◽  
Xin-Li Liu ◽  
Lei Fan ◽  
Chen Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Lung Cancer Cells ◽  
Stat3 Signaling ◽  
Proliferation And Invasion

scholarly journals ING5 knockdown enhances migration and invasion of lung cancer cells by inducing EMT via EGFR/PI3K/Akt and IL-6/STAT3 signaling pathways

Oncotarget ◽  
2017 ◽  
Vol 8 (33) ◽  
pp. 54265-54276 ◽  
Author(s):  
Xin-Li Liu ◽  
Xu-Tao Zhang ◽  
Jin Meng ◽  
Hong-Fei Zhang ◽  
Yong Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Lung Cancer Cells ◽  
Migration And Invasion ◽  
Stat3 Signaling

scholarly journals Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways

Biology Open ◽  
2016 ◽  
Vol 5 (6) ◽  
pp. 794-800 ◽  
Author(s):  
Xian-Jie Zheng ◽  
Zhong-Xin Yang ◽  
Yan-Jun Dong ◽  
Guo-Yu Zhang ◽  
Ming-Fei Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Lung Cancer Cells ◽  
Stat3 Signaling

scholarly journals SUMO1 promotes the proliferation and invasion of non-small cell lung cancer cells by regulating NF-κB

2018 ◽  
Vol 10 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Changkang Ke ◽  
Kai Zhu ◽  
Ying Sun ◽  
Yunfeng Ni ◽  
Zhipei Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Proliferation And Invasion

scholarly journals Histone deacetylase�5 promotes the proliferation and invasion of lung cancer cells

2018 ◽  
Author(s):  
Lou Zhong ◽  
Siyuan Sun ◽  
Sumei Yao ◽  
Xiao Han ◽  
Mingming Gu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Lung Cancer Cells ◽  
Proliferation And Invasion

scholarly journals Rhophilin-2 Upregulates Glutamine Synthetase by Stabilizing c-Myc Protein and Confers Resistance to Glutamine Deprivation in Lung Cancer

2021 ◽  
Vol 10 ◽  
Author(s):  
Dakai Xiao ◽  
Jiaxi He ◽  
Zhihua Guo ◽  
Huiming He ◽  
Shengli Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Glutamine Synthetase ◽  
Lung Adenocarcinoma ◽  
Cancer Cells ◽  
Clinical Sample ◽  
Glutamine Metabolism ◽  
Lung Cancer Cells ◽  
Mesenchymal Transformation ◽  
Proliferation And Invasion

IntroductionRHPN2, a member of rhophilin family of rho-binding proteins, regulates actin cytoskeleton and vesicular trafficking, and promotes mesenchymal transformation in cancer. We have found that RHPN2 was significantly mutated in lung adenocarcinoma (LUAD). However, the role of RHPN2 in lung cancer is not fully understood.MethodsIn the present study, we investigated the expression of RHPN2 in 125 patients with LUAD by qRT-PCR and correlated its expression with clinical characteristics. The effects of RHPN2 on the proliferation and invasion of lung cancer cells were determined by CCK-8 and in vitro transwell assays, clonogenic assay, and xenograft mouse model. The RhoA pull down assay and Western blotting were performed to elucidate the mechanism of RNPN2 in tumorigenesis of lung cancer.ResultsRHPN2 was overexpressed in tumors from LUAD, and high levels of RHPN2 were associated with poor prognosis of LUAD patients. RHPN2 was required for proliferation and invasion of lung cancer cells. Intriguingly, overexpression of RHPN2 conferred the resistance to glutamine depletion in lung cancer cells. Mechanistic studies revealed that ectopic overexpression of RHPN2 promoted the stability of c-Myc protein via phosphorylation at Ser62 and increased c-Myc target glutamine synthetase (GS). Analysis of GS expression in clinical sample showed that the expression of GS was elevated in tumor cells. Kaplan-Meier analysis revealed that high levels of GS were significantly associated with worse overall survival time of the patients with LUAD.ConclusionsTaken together, this study suggested that RHPN2 was involved in tumorigenesis of lung cancer via modulating c-Myc stability and the expression of its target GS in lung adenocarcinoma, which links RHPN2 and glutamine metabolism.

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