NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway

2013 ◽  
Vol 25 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Peter W. Eide ◽  
Lina Cekaite ◽  
Stine A. Danielsen ◽  
Ina A. Eilertsen ◽  
Ane Kjenseth ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Akt Pathway

scholarly journals The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth

2016 ◽  
Vol 55 (12) ◽  
pp. 2196-2209 ◽  
Author(s):  
Ying Yng Choy ◽  
Magdalena Fraga ◽  
Gerardo G. Mackenzie ◽  
Andrew L. Waterhouse ◽  
Eleonora Cremonini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Akt Pathway ◽  
Human Colorectal Cancer ◽  
Cancer Cell Growth ◽  
Human Colorectal Cancer Cell

scholarly journals SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway

2019 ◽  
Vol 16 (12) ◽  
pp. 1573-1582 ◽  
Author(s):  
Qian Wang ◽  
Shengnan Jia ◽  
Yan Jiao ◽  
Libo Xu ◽  
Ding Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Akt Pathway ◽  
Cancer Cell Growth

ESM-1 regulates cell growth and metastatic process through activation of NF-κB in colorectal cancer

2012 ◽  
Vol 24 (10) ◽  
pp. 1940-1949 ◽  
Author(s):  
Yun Hee Kang ◽  
Na Young Ji ◽  
Seung Ro Han ◽  
Chung Il Lee ◽  
Jae Wha Kim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Metastatic Process

scholarly journals Dehydrodiisoeugenol inhibits colorectal cancer growth by endoplasmic reticulum stress-induced autophagic pathways

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Changhong Li ◽  
Kui Zhang ◽  
Guangzhao Pan ◽  
Haoyan Ji ◽  
Chongyang Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Endoplasmic Reticulum ◽  
Cell Growth ◽  
Er Stress ◽  
Cancer Cells ◽  
Tumor Xenograft ◽  
Anticancer Activities ◽  
Colorectal Cancer Cells

Abstract Background Dehydrodiisoeugenol (DEH), a novel lignan component extracted from nutmeg, which is the seed of Myristica fragrans Houtt, displays noticeable anti-inflammatory and anti-allergic effects in digestive system diseases. However, the mechanism of its anticancer activity in gastrointestinal cancer remains to be investigated. Methods In this study, the anticancer effect of DEH on human colorectal cancer and its underlying mechanism were evaluated. Assays including MTT, EdU, Plate clone formation, Soft agar, Flow cytometry, Electron microscopy, Immunofluorescence and Western blotting were used in vitro. The CDX and PDX tumor xenograft models were used in vivo. Results Our findings indicated that treatment with DEH arrested the cell cycle of colorectal cancer cells at the G1/S phase, leading to significant inhibition in cell growth. Moreover, DEH induced strong cellular autophagy, which could be inhibited through autophagic inhibitors, with a rction in the DEH-induced inhibition of cell growth in colorectal cancer cells. Further analysis indicated that DEH also induced endoplasmic reticulum (ER) stress and subsequently stimulated autophagy through the activation of PERK/eIF2α and IRE1α/XBP-1 s/CHOP pathways. Knockdown of PERK or IRE1α significantly decreased DEH-induced autophagy and retrieved cell viability in cells treated with DEH. Furthermore, DEH also exhibited significant anticancer activities in the CDX- and PDX-models. Conclusions Collectively, our studies strongly suggest that DEH might be a potential anticancer agent against colorectal cancer by activating ER stress-induced inhibition of autophagy.

Action of a library of O-glycosylation inhibitors on the growth of human colorectal cancer cells in culture

2005 ◽  
Vol 33 (4) ◽  
pp. 721-723 ◽  
Author(s):  
G. Patsos ◽  
V. Hebbe-Viton ◽  
R. San Martin ◽  
C. Paraskeva ◽  
T. Gallagher ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cell Lines ◽  
Growth Patterns ◽  
Limited Information ◽  
Human Colorectal Cancer ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cells ◽  
Colorectal Cancer Cell Lines

O-glycosylation is thought to play a significant role in the regulation of cell growth. However, only limited information is available, and few specific and selective inhibitors have been found. We have synthesized a library of O-glycosylation inhibitors based on benzyl-O-N-acetyl-D-galactosamine. These inhibitors were tested with an established series of human colorectal cancer cell lines, which model the adenoma-carcinoma sequence. Cancer cells were incubated with the inhibitors, and examined for cell growth patterns, and cellular and subcellular glycosylation using a range of lectins with confocal microscopy. The specificity of O-glycan inhibition was confirmed for the library, relative to other forms of glycosylation. All inhibitors tested resulted in smaller cell yields. However, a differential effect on O-glycosylation was detected using the lectins showing variation of localization at a subcellular level in the various cell lines. Further differential action of the inhibitor library was observed for apoptosis and on the cell cycle with the cell lines tested. This work demonstrates that O-glycosylation is closely involved in the regulation of cell growth in colorectal cancer cells and that the generation of a library of low-molecular-mass inhibitors offers a valuable means of examining this regulation at the molecular level.

scholarly journals Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer

2018 ◽  
Vol 46 (11) ◽  
pp. 5809-5821 ◽  
Author(s):  
Yang Lan ◽  
Xuewei Xiao ◽  
Zhengchi He ◽  
Yu Luo ◽  
Chuanfang Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Long Noncoding Rna ◽  
Noncoding Rna
Sign in / Sign up

Export Citation Format

Share Document