Hypoxia inducible factor 1α: A critical factor for the immune response to pathogens and Leishmania

2016 ◽  
Vol 309 ◽  
pp. 42-49 ◽  
Author(s):  
Tania Charpentier ◽  
Akil Hammami ◽  
Simona Stäger
Keyword(s):  
Immune Response ◽  
Hypoxia Inducible Factor ◽  
Critical Factor ◽  
Hypoxia Inducible Factor 1Α

Letter to the Editor: Hypoxia inducible factor 1α: A critical factor for the immune response to pathogens and Leishmania

2016 ◽  
Vol 310 ◽  
pp. 211 ◽  
Author(s):  
Fatma Z. Guerfali ◽  
Julien Lemaire ◽  
Ghada Mkannez ◽  
Patricia Renard ◽  
Dhafer Laouini
Keyword(s):  
Immune Response ◽  
Hypoxia Inducible Factor ◽  
Critical Factor ◽  
Hypoxia Inducible Factor 1Α ◽  
Letter To The Editor

scholarly journals Crosstalk Between Autophagy and Hypoxia-Inducible Factor-1α in Antifungal Immunity

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2150 ◽  
Author(s):  
Tim Quäschling ◽  
Dirk Friedrich ◽  
George S. Deepe ◽  
Jan Rupp
Keyword(s):  
Immune Response ◽  
Immune Cells ◽  
Fungal Pathogens ◽  
Molecular Mechanisms ◽  
Fungal Infections ◽  
Hypoxia Inducible Factor ◽  
Canonical Pathway ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Hypoxia Inducible Factor 1Α

Modern medicine is challenged by several potentially severe fungal pathogens such as Aspergillus fumigatus, Candida albicans, or Histoplasma capsulatum. Though not all fungal pathogens have evolved as primary pathogens, opportunistic pathogens can still cause fatal infections in immuno-compromised patients. After infection with these fungi, the ingestion and clearance by innate immune cells is an important part of the host immune response. Innate immune cells utilize two different autophagic pathways, the canonical pathway and the non-canonical pathway, also called microtubule-associated protein 1A/1B-light chain 3 (LC3) -associated pathway (LAP), to clear fungal pathogens from the intracellular environment. The outcome of autophagy-related host immune responses depends on the pathogen and cell type. Therefore, the understanding of underlying molecular mechanisms of autophagy is crucial for the development and improvement of antifungal therapies. One of those molecular mechanisms is the interaction of the transcription-factor hypoxia-inducible factor 1α (HIF-1α) with the autophagic immune response. During this review, we will focus on a comprehensive overview of the role of autophagy and HIF-1α on the outcome of fungal infections.

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