Protective function of an unconventional γδ T cell subset against malaria infection in apoptosis inhibitor deficient mice

2012 ◽  
Vol 279 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Changchun Li ◽  
Kaiissar Mannoor ◽  
Masashi Inafuku ◽  
Tomoyo Taniguchi ◽  
Yuba Inamine ◽  
...  
Keyword(s):  
T Cell ◽  
Malaria Infection ◽  
Cell Subset ◽  
Γδ T Cell ◽  
Protective Function ◽  
T Cell Subset ◽  
Apoptosis Inhibitor ◽  
Deficient Mice

Expansion of the γδ T cell subset in vivo during bloodstage malaria in B cell-deficient mice

1996 ◽  
Vol 60 (2) ◽  
pp. 221-229 ◽  
Author(s):  
Henri C. van der Heyde ◽  
M. Merle Elloso ◽  
Wun-Ling Chang ◽  
Barbara J. Pepper ◽  
Joan Batchelder ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
Cell Subset ◽  
Γδ T Cell ◽  
T Cell Subset ◽  
Deficient Mice

Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity

2020 ◽  
Author(s):  
Hannah Kaminski ◽  
Coline Ménard ◽  
Bouchra El Hayani ◽  
And-Nan Adjibabi ◽  
Gabriel Marsères ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Cell Subset ◽  
Γδ T Cells ◽  
Specific Marker ◽  
Dependent Manner ◽  
Γδ T Cell ◽  
T Cell Subset ◽  
Cmv Disease

Abstract Cytomegalovirus (CMV) is a major infectious cause of death and disease after transplantation. We have previously demonstrated that the tissue-associated adaptive Vδ2neg γδ T cells are key effectors responding to CMV and associated with recovery, contrasting with their innatelike circulating counterparts, the Vγ9posVδ2pos T cells that respond to phosphoantigens but not to CMV. A third Vγ9negVδ2pos subgroup with adaptive functions has been described in adults. In the current study, we demonstrate that these Vγ9negVδ2pos T cells are also components of the CMV immune response while presenting with distinct characteristics from Vδ2neg γδ T cells. In a cohort of kidney transplant recipients, CMV seropositivity was the unique clinical parameter associated with Vγ9negVδ2pos T-cell expansion and differentiation. Extensive phenotyping demonstrated their substantial cytotoxic potential and activation during acute CMV primary infection or reinfection. In vitro, Vγ9negVδ2pos T cells responded specifically to CMV-infected cells in a T-cell receptor–dependent manner and through strong interferon γ production. Finally, Vγ9negVδ2pos T cells were the only γδ T-cell subset in which expansion was tightly correlated with the severity of CMV disease. To conclude, our results identify a new player in the immune response against CMV and open interesting clinical perspectives for using Vγ9negVδ2pos T cells as an immune marker for CMV disease severity in immunocompromised patients.

scholarly journals Vδ1T Lymphocytes Expressing a Th1 Phenotype Are the Major γδ T Cell Subset Infiltrating the Liver of HCV-infected Persons

2001 ◽  
Vol 7 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Chiara Agrati ◽  
Giampiero D’Offizi ◽  
Pasquale Narciso ◽  
Sergio Abrignani ◽  
Giuseppe Ippolito ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Subset ◽  
Γδ T Cell ◽  
T Cell Subset

scholarly journals Isopentenyl Pyrophosphate–Reactive Vγ9Vδ2 T Helper 1–Like Cells Are the Major γδ T Cell Subset Recovered from Lesions of Patients with Genital Herpes

2004 ◽  
Vol 190 (3) ◽  
pp. 489-493 ◽  
Author(s):  
Georges M. G. M. Verjans ◽  
R. Wim Roest ◽  
Alex van der Kooi ◽  
Grietje van Dijk ◽  
Wim I. van der Meijden ◽  
...  
Keyword(s):  
T Cell ◽  
Genital Herpes ◽  
Cell Subset ◽  
Γδ T Cell ◽  
T Helper ◽  
T Helper 1 ◽  
Isopentenyl Pyrophosphate ◽  
T Cell Subset

Biology of porcine T lymphocytes

2006 ◽  
Vol 7 (1-2) ◽  
pp. 81-96 ◽  
Author(s):  
Wasin Charerntantanakul ◽  
James A. Roth
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
Cell Subset ◽  
Γδ T Cells ◽  
T Cell Responses ◽  
T Cell Subsets ◽  
Γδ T Cell ◽  
T Cell Subset ◽  
Cell Responses

The present review concentrates on the biological aspects of porcine T lymphocytes. Their ontogeny, subpopulations, localization and trafficking, and responses to pathogens are reviewed. The development of porcine T cells begins in the liver during the first trimester of fetal life and continues in the thymus from the second trimester until after birth. Porcine T cells are divided into two lineages, based on their possession of the [@@@]\rmalpha [@@@]β or γδ T-cell receptor. Porcine [@@@]\rmalpha [@@@]β T cells recognize antigens in a major histocompatibility complex (MHC)-restricted manner, whereas the γδ T cells recognize antigens in a MHC non-restricted fashion. The CD4+CD8−and CD4+CD8loT cell subsets of [@@@]\rmalpha [@@@]β T cells recognize antigens presented in MHC class II molecules, while the CD4−CD8+T cell subset recognizes antigens presented in MHC class I molecules. Porcine [@@@]\rmalpha [@@@]β T cells localize mainly in lymphoid tissues, whereas γδ T cells predominate in the blood and intestinal epithelium of pigs. Porcine CD8+[@@@]\rmalpha [@@@]β T cells are a prominent T-cell subset during antiviral responses, while porcine CD4+[@@@]\rmalpha [@@@]β T cell responses predominantly occur in bacterial and parasitic infections. Porcine γδ T cell responses have been reported in only a few infections. Porcine T cell responses are suppressed by some viruses and bacteria. The mechanisms of T cell suppression are not entirely known but reportedly include the killing of T cells, the inhibition of T cell activation and proliferation, the inhibition of antiviral cytokine production, and the induction of immunosuppressive cytokines.

scholarly journals A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence

Immunity ◽  
2018 ◽  
Vol 48 (2) ◽  
pp. 350-363.e7 ◽  
Author(s):  
Murad R. Mamedov ◽  
Anja Scholzen ◽  
Ramesh V. Nair ◽  
Katherine Cumnock ◽  
Justin A. Kenkel ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Subset ◽  
Γδ T Cell ◽  
Colony Stimulating Factor ◽  
T Cell Subset ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor
Sign in / Sign up

Export Citation Format

Share Document