The attenuation of cockroach allergy by DNA vaccine encoding cockroach allergen Bla g 2

2012 ◽  
Vol 278 (1-2) ◽  
pp. 120-124 ◽  
Author(s):  
Bin Zhou ◽  
Jingdong Yuan ◽  
Yixuan Zhou ◽  
Jun Yang ◽  
Alan W. James ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Cockroach Allergen ◽  
Cockroach Allergy

Cockroach allergy and exposure to cockroach allergen in Polish children with asthma

Allergy ◽  
2002 ◽  
Vol 57 (8) ◽  
pp. 701-705 ◽  
Author(s):  
I. Stelmach ◽  
J. Jerzynska ◽  
W. Stelmach ◽  
P. Majak ◽  
G. Chew ◽  
...  
Keyword(s):  
Cockroach Allergen ◽  
Children With Asthma ◽  
Cockroach Allergy

The Role of Cockroach Allergy and Exposure to Cockroach Allergen in Causing Morbidity among Inner-City Children with Asthma

1997 ◽  
Vol 336 (19) ◽  
pp. 1356-1363 ◽  
Author(s):  
David L. Rosenstreich ◽  
Peyton Eggleston ◽  
Meyer Kattan ◽  
Dean Baker ◽  
Raymond G. Slavin ◽  
...  
Keyword(s):  
Inner City ◽  
Cockroach Allergen ◽  
Children With Asthma ◽  
Cockroach Allergy

scholarly journals Cockroach Allergen Bla g 7 Promotes TIM4 Expression in Dendritic Cells Leading to Th2 Polarization

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Lingxiao Xu ◽  
Miaojia Zhang ◽  
Wenjing Ma ◽  
Shanshan Jin ◽  
Weijuan Song ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Allergic Diseases ◽  
Cockroach Allergen ◽  
Th2 Polarization ◽  
Indoor Aeroallergens ◽  
Cockroach Allergy

As one of the most common sources of indoor aeroallergens worldwide, cockroach is important in causing rhinitis and asthma while the mechanisms underlying remain obscure. Since T helper (Th) type 2 polarization plays an important role in the pathogenesis of allergic diseases, we investigated the effect of Bla g 7, a pan-allergen fromBlattella germanica(B. germanica), on Th polarization which is controlled by monocyte-derived dendritic cells (DCs). Challenged by recombinant Bla g 7 (rBla g 7), immature DCs obtained from human exhibited upregulated levels of TIM4, CD80, and CD86 and increased IL-13 secretion. Cocultured with CD4+ T cells, challenged DCs increased the ratio of IL-4+ versus IFN-γ+ of CD4+ T cells, suggesting a balance shift from Th1 to Th2. Moreover, antibodies against TIM4, CD80, and CD86 reversed the enhancement of IL-4+/IFN-γ+ ratio and alleviated the IL-13 release induced by rBla g 7, indicating that the Th2 polarization provoked by rBla g 7 challenged DCs is via TIM4-, CD80-, and CD86-dependent mechanisms. In conclusion, the present findings implied a crucial role of Bla g 7 in the development of cockroach allergy and highlighted an involvement of DCs-induced Th2 polarization in cockroach allergy.

Characterization of The Protective and Therapeutic Efficiency of a DNA Vaccine Encoding The Cockroach Allergen Bla g 1

2006 ◽  
Vol 117 (2) ◽  
pp. S277
Author(s):  
B. Zhou ◽  
M. Ensell ◽  
J. Glickstein ◽  
C. Cai ◽  
M. Kermany ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Therapeutic Efficiency ◽  
Cockroach Allergen

843-P: Optimization of DNA Vaccine Platforms for Type 1 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 843-P
Author(s):  
JORGE POSTIGO FERNANDEZ
Keyword(s):  
Type 1 Diabetes ◽  
Dna Vaccine
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