Cholecystokinin octapeptide significantly suppresses collagen-induced arthritis in mice by inhibiting Th17 polarization primed by dendritic cells

2011 ◽  
Vol 272 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Qiaoxia Li ◽  
Dongyan Han ◽  
Bin Cong ◽  
Baoen Shan ◽  
Jingge Zhang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Collagen Induced Arthritis ◽  
Cholecystokinin Octapeptide

scholarly journals Synergistic Effect of Tolerogenic Dendritic Cells and Etanercept on a Collagen-induced Arthritis Animal Model

2019 ◽  
Vol 28 (3) ◽  
pp. 265-272
Author(s):  
Sang Youn Jung ◽  
Kil-Sang Cho ◽  
Doo-Rye Jang ◽  
Jun-Ho Lee ◽  
So-Yeon Choi ◽  
...  
Keyword(s):  
Animal Model ◽  
Dendritic Cells ◽  
Synergistic Effect ◽  
Collagen Induced Arthritis ◽  
Tolerogenic Dendritic Cells

scholarly journals Tolerogenic Splenic IDO+Dendritic Cells from the Mice Treated with Induced-Treg Cells Suppress Collagen-Induced Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Jie Yang ◽  
Yiming Yang ◽  
Huahua Fan ◽  
Hejian Zou
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Foxp3 Expression ◽  
Treated Group ◽  
Treg Cells ◽  
Therapeutic Effects ◽  
Dependent Manner ◽  
Collagen Induced Arthritis

TGF-β-induced regulatory T cells (iTregs) retain Foxp3 expression and immune-suppressive activity in collagen-induced arthritis (CIA). However, the mechanisms whereby transferred iTregs suppress immune responses, particularly the interplay between iTregs and dendritic cells (DCs)in vivo, remain incompletely understood. In this study, we found that after treatment with iTregs, splenic CD11c+DCs, termed “DCiTreg,” expressed tolerogenic phenotypes, secreted high levels of IL-10, TGF-β, and IDO, and showed potent immunosuppressive activityin vitro. After reinfusion with DCiTreg, marked antiarthritic activity improved clinical scores and histological end-points were observed. The serological levels of inflammatory cytokines and anti-CII antibodies were low and TGF-βproduction was high in the DCiTreg-treated group. DCiTregalso induced new iTregsin vivo. Moreover, the inhibitory activity of DCiTregon CIA was lost following pretreatment with the inhibitor of indoleamine 2,3-dioxygenase (IDO). Collectively, these findings suggest that transferred iTregs could induce tolerogenic characteristics in splenic DCs and these cells could effectively dampen CIA in an IDO-dependent manner. Thus, the potential therapeutic effects of iTregs in CIA are likely maintained through the generation of tolerogenic DCsin vivo.

scholarly journals Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Corina Peña ◽  
David Gárate ◽  
Juan Contreras-Levicoy ◽  
Octavio Aravena ◽  
Diego Catalán ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Combined Treatment ◽  
Type Ii Collagen ◽  
Cytokine Profile ◽  
Clinical Disease ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Short Term

Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen-(CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a preconditioning agent, followed by an injection of lipopolysaccharide-(LPS-) stimulated and CII-loaded DCs on the CIA course.Methods. After CIA induction, mice pretreated with DXM were injected with 4-hour LPS-stimulated DCs loaded with CII (DXM/4hLPS/CII/DCs).Results. Mice injected with DXM/4hLPS/CII/DCs displayed significantly less severe clinical disease compared to animals receiving 4hLPS/CII/DCs alone or those in which only DXM was administered. Cytokine profile evaluation showed that CD4+ T cells from DXM/4hLPS/CII/DCs and 4hLPS/CII/DCs groups release higher IL-10 levels than those from mice receiving DXM alone or CIA mice. CD4+ T cells from all DC-treated groups showed less IL-17 release when compared to the CIA group. On the contrary, CD4+ T cells from DXM/4hLPS/CII/DCs and 4hLPS/CII/DCs groups released higher IFN-γlevels than those from CIA group.Conclusion. A combined treatment, including DXM preconditioning followed by an inoculation of short-term LPS-stimulated CII-loaded DCs, provides an improved strategy for attenuating CIA severity. Our results suggest that this benefit is driven by a modulation in the cytokine profile secreted by CD4+ T cells.

The anti-spasticity drug baclofen alleviates collagen-induced arthritis and regulates dendritic cells

2015 ◽  
Vol 230 (7) ◽  
pp. 1438-1447 ◽  
Author(s):  
Shichao Huang ◽  
Jianxin Mao ◽  
Bin Wei ◽  
Gang Pei
Keyword(s):  
Dendritic Cells ◽  
Collagen Induced Arthritis

scholarly journals CD8α+ dendritic cells improve collagen-induced arthritis in CC chemokine receptor (CCR)-2 deficient mice

Immunobiology ◽  
2011 ◽  
Vol 216 (9) ◽  
pp. 971-978 ◽  
Author(s):  
Jessica M. Ibarra ◽  
Marlon P. Quinones ◽  
Carlos A. Estrada ◽  
Fabio Jimenez ◽  
Hernan G. Martinez ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Chemokine Receptor ◽  
Collagen Induced Arthritis ◽  
Cc Chemokine ◽  
Deficient Mice

scholarly journals Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides

2017 ◽  
Vol Volume 11 ◽  
pp. 2997-3007 ◽  
Author(s):  
Hongmei Jiang ◽  
Henggui Hu ◽  
Yali Zhang ◽  
Ping Yue ◽  
Lichang Ning ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Collagen Induced Arthritis ◽  
Nf Kappa B

CD8alpha+ dendritic cells enhance the antigen-specific CD4+ T-cell response and accelerate development of collagen-induced arthritis

2007 ◽  
Vol 111 (2) ◽  
pp. 76-83 ◽  
Author(s):  
Young Ok Jung ◽  
So-Youn Min ◽  
Mi-La Cho ◽  
Min-Jung Park ◽  
Ju-Youn Jeon ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Collagen Induced Arthritis ◽  
Accelerate Development

scholarly journals Helminth Antigens Enable CpG-Activated Dendritic Cells to Inhibit the Symptoms of Collagen-induced Arthritis through Foxp3+ Regulatory T Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40356 ◽  
Author(s):  
Franco Carranza ◽  
Cristian Roberto Falcón ◽  
Nicolás Nuñez ◽  
Carolina Knubel ◽  
Silvia Graciela Correa ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Collagen Induced Arthritis
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