Overexpression of megsin induces mesangial cell proliferation and excretion of type IV collagen in vitro

2011 ◽  
Vol 271 (2) ◽  
pp. 413-417 ◽  
Author(s):  
Yunfeng Xia ◽  
Yimin Zhang ◽  
Wei Shi ◽  
Shuangxin Liu ◽  
Yuanhan Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Type Iv Collagen ◽  
Mesangial Cell ◽  
Type Iv ◽  
Mesangial Cell Proliferation

scholarly journals Effect of pravastatin on type IV collagen secretion and mesangial cell proliferation

1999 ◽  
Vol 56 ◽  
pp. S97-S100 ◽  
Author(s):  
Motonobu Nishimura ◽  
Tomoaki Tanaka ◽  
Tatsuji Yasuda ◽  
Shinichi Kurakata ◽  
Masatoshi Kitagawa ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Type Iv Collagen ◽  
Mesangial Cell ◽  
Type Iv ◽  
Collagen Secretion ◽  
Mesangial Cell Proliferation

scholarly journals Anti-angiogenic compound (TNP-470) inhibits mesangial cell proliferation in vitro and in vivo

1997 ◽  
Vol 51 (6) ◽  
pp. 1838-1846 ◽  
Author(s):  
Masashi Haraguchi ◽  
Mikio Okamura ◽  
Masayo Konishi ◽  
Yoshio Konishi ◽  
Nobuo Negoro ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation ◽  
Proliferation In Vitro

scholarly journals Roles of E2F1 in mesangial cell proliferation in vitro

1999 ◽  
Vol 56 (6) ◽  
pp. 2085-2095 ◽  
Author(s):  
Seiji Inoshita ◽  
Yoshio Terada ◽  
Osamu Nakashima ◽  
Michio Kuwahara ◽  
Sei Sasaki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation ◽  
Proliferation In Vitro

scholarly journals Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo.

1998 ◽  
Vol 101 (11) ◽  
pp. 2589-2597 ◽  
Author(s):  
Y Maeshima ◽  
N Kashihara ◽  
T Yasuda ◽  
H Sugiyama ◽  
T Sekikawa ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation

C-peptide induces human renal mesangial cell proliferation in vitro, activating Src-kinase, PI-3 kinase and ERK1/2

2012 ◽  
Vol 351 (2) ◽  
pp. 337-341 ◽  
Author(s):  
Dusica Vasic ◽  
Andreas Spyrantis ◽  
Renate Durst ◽  
Helga Bach ◽  
Sonja Vogt ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Src Kinase ◽  
C Peptide ◽  
Mesangial Cell Proliferation ◽  
Proliferation In Vitro

scholarly journals Ergosterol Ameliorates Diabetic Nephropathy by Attenuating Mesangial Cell Proliferation and Extracellular Matrix Deposition via the TGF-β1/Smad2 Signaling Pathway

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 483 ◽  
Author(s):  
Zhonghua Dong ◽  
Yueyue Sun ◽  
Guangwei Wei ◽  
Siying Li ◽  
Zhongxi Zhao
Keyword(s):  
Extracellular Matrix ◽  
Cell Proliferation ◽  
Diabetic Nephropathy ◽  
Signaling Pathway ◽  
Mesangial Cell ◽  
Mesangial Cells ◽  
Diabetic Mice ◽  
Mesangial Cell Proliferation ◽  
Tgf Β1

(1) Background: Diabetic nephropathy, a microvascular complication of diabetes, is one of the principal causes of end-stage renal disease worldwide. The aim of this study was to explore the therapeutic effects of ergosterol on diabetic nephropathy. (2) Methods: Streptozotocin (STZ)-induced C57BL/6 diabetic mice were treated with ergosterol (10, 20, 40 mg/kg/day) for 8 weeks by oral gavage. The in vitro study employed rat mesangial cells exposed to 30 mM glucose for 48 h in the presence of 10 or 20 μM ergosterol. (3) Results: Ergosterol treatment improved body weights, ameliorated the majority of biochemical and renal functional parameters and histopathological changes, and reduced extracellular matrix (ECM) deposition in diabetic mice. In vitro, ergosterol suppressed proliferation, reduced the levels of ECM proteins, and increased the expression of matrix metalloproteinase-2 and -9 in high glucose-induced mesangial cells; Furthermore, ergosterol markedly improved transforming growth factor-β1 (TGF-β1) expression, enhanced phosphorylation levels of drosophila mothers against decapentaplegic 2 (Smad2), and regulated the downstream factors in vivo and in vitro. (4) Conclusions: Ergosterol alleviated mesangial cell proliferation and the subsequent ECM deposition by regulating the TGF-β1/Smad2 signaling pathway.

scholarly journals Suppressive effects of fish oil on mesangial cell proliferation in vitro and in vivo

2000 ◽  
Vol 57 (3) ◽  
pp. 1027-1040 ◽  
Author(s):  
Joseph P. Grande ◽  
Henry J. Walker ◽  
Bruce J. Holub ◽  
Gina M. Warner ◽  
Dawn M. Keller ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Fish Oil ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation ◽  
Proliferation In Vitro
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