scholarly journals Fc Glycan-Mediated Regulation of Placental Antibody Transfer

Cell ◽  
2019 ◽  
Vol 178 (1) ◽  
pp. 202-215.e14 ◽  
Author(s):  
Madeleine F. Jennewein ◽  
Ilona Goldfarb ◽  
Sepideh Dolatshahi ◽  
Cormac Cosgrove ◽  
Francesca J. Noelette ◽  
...  
2021 ◽  
Vol 224 (2) ◽  
pp. S722
Author(s):  
Naima T. Joseph ◽  
Anne L. Dunlop ◽  
Ravi M. Patel ◽  
Martina Badell ◽  
Carolynn Dude

2019 ◽  
Vol 75 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Zinia T. Nujum ◽  
N. Saritha ◽  
M.R. Prathibha Raj ◽  
A.V. Gayathri ◽  
C. Nirmala ◽  
...  

Cell ◽  
2020 ◽  
Author(s):  
Caroline Atyeo ◽  
Krista M. Pullen ◽  
Evan A. Bordt ◽  
Stephanie Fischinger ◽  
John Burke ◽  
...  

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Naima T. Joseph ◽  
Carolynn M. Dude ◽  
Hans P. Verkerke ◽  
Les’Shon S. Irby ◽  
Anne L. Dunlop ◽  
...  

mSphere ◽  
2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Esther Ndungo

ABSTRACT Esther Ndungo works in the field of maternal-infant immunity against enteric pathogens. In this mSphere of Influence article, she reflects on how the paper “Fc glycan-mediated regulation of placental antibody transfer” by Jennewein et al. (M. F. Jennewein, I. Goldfarb, S. Dolatshahi, C. Cosgrove, et al., Cell 178:202–215.e14, 2019, https://doi.org/10.1016/j.cell.2019.05.044) impressed upon her the value of thinking “outside the box” and looking to nature to guide her research.


1998 ◽  
Vol 79 (3) ◽  
pp. F202-F205 ◽  
Author(s):  
M I. de Moraes-Pinto ◽  
F. Verhoeff ◽  
L. Chimsuku ◽  
P. J M Milligan ◽  
L. Wesumperuma ◽  
...  

2017 ◽  
Vol 24 (6) ◽  
Author(s):  
Noah D. McKittrick ◽  
David M. Vu ◽  
Indu Malhotra ◽  
Charles H. King ◽  
Francis Mutuku ◽  
...  

ABSTRACT Many factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. However, little is known about the effect of maternal parasitic infection on placental antibody transfer. To investigate this, we selected from a parent study of 576 pregnant Kenyan women four groups of women with term deliveries (≥37 weeks), including uninfected women (n = 30) and women with solo infections with malaria (n = 30), hookworm (n = 30), or schistosomiasis (n = 10). Maternal plasma at delivery and infant cord blood were tested via multiplex fluorescent bead assay for IgG against 10 pneumococcal serotypes (PnPs 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F), diphtheria toxoid, and Haemophilus influenzae type B. Infants born to mothers with prenatal malaria, hookworm, or Schistosoma haematobium infections were associated with a significantly reduced ratio of maternal to infant cord blood antibody concentration for Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, and 18C compared to infants of uninfected mothers. Anti-diphtheria toxoid and anti-H. influenzae type B IgG ratios were not significantly different among infection groups. Prenatal parasitic infections decrease the transfer of maternal IgG antibodies to infants for several serotypes of S. pneumoniae.


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