scholarly journals Comprehensive Analysis of Hypermutation in Human Cancer

Cell ◽  
2017 ◽  
Vol 171 (5) ◽  
pp. 1042-1056.e10 ◽  
Author(s):  
Brittany B. Campbell ◽  
Nicholas Light ◽  
David Fabrizio ◽  
Matthew Zatzman ◽  
Fabio Fuligni ◽  
...  
Keyword(s):  
Human Cancer ◽  
Comprehensive Analysis

Comprehensive Analysis and Prediction of the Essential Genes in Human Cancer Cells

2018 ◽  
Author(s):  
Yuwei Zhang ◽  
Yang Tao ◽  
Huihui Ji ◽  
Wei Li ◽  
Xingli Guo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Comprehensive Analysis ◽  
Essential Genes ◽  
Human Cancer Cells

scholarly journals Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer types

Oncotarget ◽  
2016 ◽  
Vol 7 (17) ◽  
pp. 23043-23055 ◽  
Author(s):  
Isabella Syring ◽  
Niklas Klümper ◽  
Anne Offermann ◽  
Martin Braun ◽  
Mario Deng ◽  
...  
Keyword(s):  
Human Cancer ◽  
Comprehensive Analysis ◽  
Transcriptional Profile ◽  
Mediator Complex ◽  
Cancer Types

scholarly journals Comprehensive Analysis of TGF β & β – Catenin Components in Various Human Cancer Tissues

2021 ◽  
Vol 9 (1) ◽  
pp. 29
Author(s):  
Jamila Sameer Daraghmeh ◽  
Bayan Mustafa Mansour ◽  
Asmaa Yousef Kmail ◽  
Iqab Ghalib Daraghmeh
Keyword(s):  
Molecular Basis ◽  
Human Cancer ◽  
Distinct Group ◽  
Comprehensive Analysis ◽  
Cancer Therapies ◽  
Ability To Act ◽  
Human Protein Atlas ◽  
Cancer Types ◽  
Tumor Types ◽  
Cancer Tissues

Studies over the last years revealed significant insights into the β-Catenin & TGF β signal transduction pathways and that such pathways are abnormal activated in abundant cancer types. According to the straight forward effect of these pathways in various tumor types, both pathways are currently considered targets for innovative cancer therapies. This view study emphasizes 13 proteins that are implicated in these two pathways. As there has been widespread research into the proteins that involved in these pathways, we have utilized data existing in the Human Protein Atlas database in this paper to examine the expression of 53 crucial proteins that are recognized to be involved in the activation of these pathways in a distinct group of 45 cancer types. Our findings revealed notably that the proteins (SKIL, SHC, ERK1/2, RAS, PI3K (PIK3CA), SMAD8, ACVR2A/1B SNON, AKT, and SMAD3, from TGF β and (RNF43, SNAIL1 and DVl) for β catenin show high expression in most caner tissues. Our results strongly suggest that these proteins might have the ability to act as potential objects for remedies and provide perception into the molecular basis of cancer.

scholarly journals Comprehensive analysis on expression profile and prognostic values of SYTs family members and their methylation in gastric cancer

2021 ◽  
Author(s):  
Mei-feng Yang ◽  
Xing-xing Long ◽  
Hong-sai Hu ◽  
Yu-ling Bin ◽  
Li-sheng Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Immune Cells ◽  
Bioinformatics Analysis ◽  
Human Cancer ◽  
Family Members ◽  
Progression Free Survival ◽  
Comprehensive Analysis ◽  
Free Survival ◽  
Online Databases ◽  
Low Expression

Abstract Background: Synaptotagmins (SYTs) family members, consisting of 17 isoforms, paly crucial roles in the development and progression of human cancer. However, there is few studies on the expression and prognostic values of SYTs family in gastric cancer (GC). Methods: We comprehensively evaluate the expression, methylation, prognosis and immune significance of SYTs family members through bioinformatics analysis from the online databases in GC. Results: The expressions of SYT4, SYT9 and SYT14 were up-regulated, and negatively associated with their methylation levels in GC. Both SYT4, SYT9 and SYT14 overexpression and their hypomethylation levels contributed to unsatisfactory overall survival (OS) and progression-free survival (PFS) in GC. Moreover, the low expression levels of methylation cg sites (cg02795029, cg07581146, cg15149095, cg19922137, cg25371503, cg26158959, cg02269161, cg03226737, cg08185661, cg16437728, cg22723056 and cg24678137) were significantly correlated with unfavorable OS and PFS in GC. Furthermore, the expression of SYT4, SYT9 and SYT14 played a pivotal role in immune cells infiltration in GC. Conclusion: SYT4, SYT9 and SYT14 might be potent prognostic indictors and promising immunotherapy targets for the patients with GC.

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia

2019 ◽  
Vol 476 (24) ◽  
pp. 3687-3704 ◽  
Author(s):  
Aphrodite T. Choumessi ◽  
Manuel Johanns ◽  
Claire Beaufay ◽  
Marie-France Herent ◽  
Vincent Stroobant ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Human Cancer ◽  
Glucose Production ◽  
Liver Mitochondria ◽  
New Drugs ◽  
Structural Isomer ◽  
Rat Liver Mitochondria ◽  
Ionization Mass ◽  
Ampk Activation ◽  
Starting Point

Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR while its structural isomer, compound 2, was isolated for the first time and differed only by the position of one double bond on one isoprenyl substituent. Treatment of MEFs with purified compound 1 or compound 2 led to rapid and robust AMPK activation at low micromolar concentrations and increased the intracellular AMP:ATP ratio. In oxygen consumption experiments on isolated rat liver mitochondria, compound 1 and compound 2 inhibited complex II of the electron transport chain and in freeze–thawed mitochondria succinate dehydrogenase was inhibited. In incubated rat skeletal muscles, both compounds activated AMPK and stimulated glucose uptake. Moreover, these effects were lost in muscles pre-incubated with AMPK inhibitor SBI-0206965, suggesting AMPK dependency. Incubation of mouse hepatocytes with compound 1 or compound 2 led to AMPK activation, but glucose production was decreased in hepatocytes from both wild-type and AMPKβ1−/− mice, suggesting that this effect was not AMPK-dependent. However, when administered intraperitoneally to high-fat diet-induced insulin-resistant mice, compound 1 and compound 2 had blood glucose-lowering effects. In addition, compound 1 and compound 2 reduced the viability of several human cancer cells in culture. The flavonoids we have identified could be a starting point for the development of new drugs to treat type 2 diabetes.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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