scholarly journals The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

Cell ◽  
2013 ◽  
Vol 153 (3) ◽  
pp. 590-600 ◽  
Author(s):  
Feng Li ◽  
Guogen Mao ◽  
Dan Tong ◽  
Jian Huang ◽  
Liya Gu ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Histone Mark ◽  
Dna Mismatch ◽  
Human Dna

scholarly journals Steady-state regulation of the human DNA mismatch repair system.

2000 ◽  
Vol 275 (37) ◽  
pp. 29178
Author(s):  
Dong Kyung Chang ◽  
Luigi Ricciardiello ◽  
Ajay Goel ◽  
Christina L. Chang ◽  
C. Richard Boland
Keyword(s):  
Steady State ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
State Regulation ◽  
Repair System ◽  
Dna Mismatch ◽  
Human Dna ◽  
Dna Mismatch Repair System ◽  
Mismatch Repair System

scholarly journals Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

2007 ◽  
Vol 35 (8) ◽  
pp. 2609-2619 ◽  
Author(s):  
Nina Østergaard Knudsen ◽  
Finn Cilius Nielsen ◽  
Lena Vinther ◽  
Ronni Bertelsen ◽  
Steen Holten-Andersen ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Nuclear Localization ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Human Dna ◽  
Repair Protein ◽  
Exonuclease 1 ◽  
Mismatch Repair Protein

scholarly journals The Bloom's Syndrome Helicase Interacts Directly with the Human DNA Mismatch Repair Protein hMSH6

2003 ◽  
Vol 384 (8) ◽  
Author(s):  
G. Pedrazzi ◽  
C. Z. Bachrati ◽  
N. Selak ◽  
I. Studer ◽  
M. Petkovic ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Bloom's Syndrome ◽  
Dna Mismatch ◽  
Human Dna ◽  
Repair Protein ◽  
Bloom’S Syndrome ◽  
Mismatch Repair Protein

Oxidative stress inactivates the human DNA mismatch repair system

2002 ◽  
Vol 283 (1) ◽  
pp. C148-C154 ◽  
Author(s):  
Christina L. Chang ◽  
Giancarlo Marra ◽  
Dharam P. Chauhan ◽  
Hannah T. Ha ◽  
Dong K. Chang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mismatch Repair ◽  
Chronic Inflammation ◽  
Dna Mismatch Repair ◽  
Repair System ◽  
Dna Microsatellites ◽  
Single Base ◽  
Dna Mismatch ◽  
Human Dna ◽  
Dna Mismatch Repair System

In the human DNA mismatch repair (MMR) system, hMSH2 forms the hMutSα and hMutSβ complexes with hMSH6 and hMSH3, respectively, whereas hMLH1 and hPMS2 form the hMutLα heterodimer. These complexes, together with other components in the MMR system, correct single-base mismatches and small insertion/deletion loops that occur during DNA replication. Microsatellite instability (MSI) occurs when the loops in DNA microsatellites are not corrected because of a malfunctioning MMR system. Low-frequency MSI (MSI-L) is seen in some chronically inflamed tissues in the absence of genetic inactivation of the MMR system. We hypothesize that oxidative stress associated with chronic inflammation might damage protein components of the MMR system, leading to its functional inactivation. In this study, we demonstrate that noncytotoxic levels of H2O2 inactivate both single-base mismatch and loop repair activities of the MMR system in a dose-dependent fashion. On the basis of in vitro complementation assays using recombinant MMR proteins, we show that this inactivation is most likely due to oxidative damage to hMutSα, hMutSβ, and hMutLα protein complexes. We speculate that inactivation of the MMR function in response to oxidative stress may be responsible for the MSI-L seen in nonneoplastic and cancer tissues associated with chronic inflammation.

Cadmium inhibits human DNA mismatch repair in vivo

2004 ◽  
Vol 321 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Anne Lützen ◽  
Sascha Emilie Liberti ◽  
Lene Juel Rasmussen
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Human Dna

scholarly journals Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair

2004 ◽  
Vol 279 (20) ◽  
pp. 20935-20940 ◽  
Author(s):  
Fenghua Yuan ◽  
Liya Gu ◽  
Shuangli Guo ◽  
Chunmei Wang ◽  
Guo-Min Li
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Hmgb1 Protein ◽  
Dna Mismatch ◽  
Human Dna

scholarly journals Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro

2017 ◽  
Vol 45 (16) ◽  
pp. 9427-9440 ◽  
Author(s):  
Dekang Liu ◽  
Jane H. Frederiksen ◽  
Sascha E. Liberti ◽  
Anne Lützen ◽  
Guido Keijzers ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Polymerase ◽  
Double Mutant ◽  
Dna Mismatch Repair ◽  
Dna Polymerase Delta ◽  
Dna Mismatch ◽  
Human Dna
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